New laser and mass spectrometry-based tools for comprehensive structural elucidation of lipids and their biomolecular interactions. Lipid-related disorders such as obesity, diabetes and heart disease are reaching epidemic proportions. We propose the development of specialised instrumentation to identify and quantify lipids (fats) in tissue and culture samples thus providing Australian scientists with unique capabilities to investigate the mechanisms of disease.
Industrial Transformation Training Centres - Grant ID: IC220100035
Funder
Australian Research Council
Funding Amount
$4,958,927.00
Summary
ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, ....ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, providing the materials and inspiration for young researchers to apply novel hyphenated methods to complex environmental and industrial systems. This Centre will deliver fundamental developments in hyphenated technologies, new analytical capability, and applied outcomes across multiple end-user groups and interests. Read moreRead less
New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordi ....New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordinary people to gain knowledge about the concentrations of molecular compounds in their environments and in themselves. This will stimulate economic and social benefits related to environmental testing and early disease diagnosis and generate new commercial opportunities for the Australian biotechnology industry.Read moreRead less
The photons take charge: Elucidating the structure and stability of distonic radical anions by mass spectrometry and photoelectron spectroscopy. Recent work has discovered that certain radical anions have electronic configurations that defy chemical convention and exhibit exceptional radical stability. Exploitation of this breakthrough first requires experimental elucidation of the intrinsic electronic structure of these compounds and how it relates to their remarkable properties. This project w ....The photons take charge: Elucidating the structure and stability of distonic radical anions by mass spectrometry and photoelectron spectroscopy. Recent work has discovered that certain radical anions have electronic configurations that defy chemical convention and exhibit exceptional radical stability. Exploitation of this breakthrough first requires experimental elucidation of the intrinsic electronic structure of these compounds and how it relates to their remarkable properties. This project will probe the fundamental structure and energetics of radical anions by modifying instrumentation to enable multi-step gas-phase ion synthesis to be efficiently coupled with anion photoelectron spectroscopy. These investigations are essential to revealing the scope of this phenomenon in free radical chemistry and biology and could inform future development of new catalysts for polymerisation.Read moreRead less
New hyphenated chromatographic and spectroscopic methods for oil analysis. This project aims to use novel chemical separation methods combined with spectroscopy to identify useful markers in olive oil and essential oil to ensure purity, quality and authenticity, which are all ongoing issues in these industries in Australia and overseas. The project plans to compare and integrate results of multidimensional gas chromatography combined with mass spectrometry and Fourier transform infrared analyses ....New hyphenated chromatographic and spectroscopic methods for oil analysis. This project aims to use novel chemical separation methods combined with spectroscopy to identify useful markers in olive oil and essential oil to ensure purity, quality and authenticity, which are all ongoing issues in these industries in Australia and overseas. The project plans to compare and integrate results of multidimensional gas chromatography combined with mass spectrometry and Fourier transform infrared analyses with data libraries to generate precise molecular identification. The outcome is expected to help monitor adulteration of oils and maintain the high quality standards of Australian produce.Read moreRead less
Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Bet ....Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Better elemental and isotope ratio data from these high-throughput instruments will open up new real-world applications in many areas of Australian interest, such as biosecurity, forensics, groundwater management, and drug design. The research will also inform design of the next generation instruments by the industry partner.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100087
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Advanced Macromolecular Materials Characterisation Facility (AMMCF). Advanced macromolecular materials characterisation facility: The facility will allow precise characterisation of (bio)macromolecular materials, from chemical structures and composition as a function of size or biodistribution, to film thickness in multi-layer materials, to material hydrophobicity and permeability. Novel information derived from these state-of-the-art instruments is highly valuable in understanding structure-pro ....Advanced Macromolecular Materials Characterisation Facility (AMMCF). Advanced macromolecular materials characterisation facility: The facility will allow precise characterisation of (bio)macromolecular materials, from chemical structures and composition as a function of size or biodistribution, to film thickness in multi-layer materials, to material hydrophobicity and permeability. Novel information derived from these state-of-the-art instruments is highly valuable in understanding structure-property relationships, which are crucial for the development of the next generation of advanced materials with applications in electronics, optics, sensors, membranes, nanocoatings, biomaterials and polymer therapeutics. This facility underpins the efforts of the participating institutes in increasing the quality and quantity of research outcomes.Read moreRead less
Surface modification of semiconducting organic charge transfer complexes with metal nanoparticles to create a new class of multifunctional materials. This project aims to deliver a facile and cheap method to produce a class of nanostructured composite materials to be used in applications which will have environmental and social benefits such as photocatalyst development for water purification, biosensing and the creation of antibacterial fabrics to prevent the spread of infection.
Nanoparticle driven templating of microspheres as chromatographic materials. This project aims to pioneer a novel, high-performing class of nano-patterned core-shell particles as chromatographic materials. It will use advanced polymerization and particle preparation techniques in combination with degradable nanoparticles design, to enable the plug-and-play assembly of chromatographic columns. Size-exclusion chromatography (SEC) is one of the most important analytical techniques for polymer chem ....Nanoparticle driven templating of microspheres as chromatographic materials. This project aims to pioneer a novel, high-performing class of nano-patterned core-shell particles as chromatographic materials. It will use advanced polymerization and particle preparation techniques in combination with degradable nanoparticles design, to enable the plug-and-play assembly of chromatographic columns. Size-exclusion chromatography (SEC) is one of the most important analytical techniques for polymer chemistry. The expected outcomes of this project are faster measurement times and the possibility of imaging molecular weight distributions at a new level of detail. This project could place Australia at the cutting edge of size-exclusion chromatography phase design in partnership with a leading manufacturer of stationary phases.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101170
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Electronic structure on both sides of the Fermi level in molecular material. This project aims to develop an inverse photoemission spectrometer to elucidate the electronic properties of molecular materials. In tandem with traditional photoemission, the spectrometer will measure the electronic structure of small molecules for organic electronics and two-dimensional graphene-analogous polymers, providing information critical to their development and use. The instrument is expected to bring critica ....Electronic structure on both sides of the Fermi level in molecular material. This project aims to develop an inverse photoemission spectrometer to elucidate the electronic properties of molecular materials. In tandem with traditional photoemission, the spectrometer will measure the electronic structure of small molecules for organic electronics and two-dimensional graphene-analogous polymers, providing information critical to their development and use. The instrument is expected to bring critical insight to the burgeoning field of molecular materials, with potential widespread applications from energy conversion to sensing and electronics, with benefits across sectors.Read moreRead less