Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237784
Funder
Australian Research Council
Funding Amount
$707,000.00
Summary
Hyphenated Separations/Mass Spectrometry Technology for Protein and Natural Product Characterisation. This proposal consolidates the 3 institutions' collaboration on the ACROSS (Australian Centre for Research on Separation Science) initiative, providing fundamental technology for chemical structural analysis of complex samples involving high resolution protein and natural product characterisation. Requested equipment supports complete characterisation of important novel target molecules. GCxGC-T ....Hyphenated Separations/Mass Spectrometry Technology for Protein and Natural Product Characterisation. This proposal consolidates the 3 institutions' collaboration on the ACROSS (Australian Centre for Research on Separation Science) initiative, providing fundamental technology for chemical structural analysis of complex samples involving high resolution protein and natural product characterisation. Requested equipment supports complete characterisation of important novel target molecules. GCxGC-TOFMS technology will validate our newly patented multidimensional separation techniques. Q-TOF-TOFMS technology, novel patented protein prefractionation approaches, and sample handling with high resolution characterisation / identification of new target proteins allows advanced proteomics developments. Proteomics depends critically upon sophisticated MS techniques. These technologies will: ·enhance the capabilities and expertise in these sciences in the SE Australian area; ·ensure the ACROSS initiative achieves internationally competitive research capabilities; ·provide commercial endpoints in fields associated with analysis of proteins, essential oils and other natural (bio)substances.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100140
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
Quarantined ion chromatography mass spectrometry (IC-MS) facility. This proposal seeks to establish a quarantined facility for 'ion chromatography-mass spectrometry', to provide high resolution ion chromatographic and mass spectrometric analytical capability to the environmental, analytical/bioanalyical, and industrial science research communities. The state-of-the-art facility will represent the only quarantined high-resolution IC-MS facility within Australia, and therefore not only support the ....Quarantined ion chromatography mass spectrometry (IC-MS) facility. This proposal seeks to establish a quarantined facility for 'ion chromatography-mass spectrometry', to provide high resolution ion chromatographic and mass spectrometric analytical capability to the environmental, analytical/bioanalyical, and industrial science research communities. The state-of-the-art facility will represent the only quarantined high-resolution IC-MS facility within Australia, and therefore not only support the above communities within Australia, but the potential to facilitate research collaboration internationally, including supporting Australia's leading Antarctic Science programs. Read moreRead less
Towards Microfluidic-Based Advanced Remote Analysis. The research under this project will establish and systematically develop Advanced Remote Analysis as a new inter-disciplinary area and establish a leadership role for Australia. By addressing pressing needs such as monitoring the environment, remote medical diagnostics, advancing Australian science and technology, or monitoring for traces of explosives, this project falls directly into all four of the National Research Priorities with applica ....Towards Microfluidic-Based Advanced Remote Analysis. The research under this project will establish and systematically develop Advanced Remote Analysis as a new inter-disciplinary area and establish a leadership role for Australia. By addressing pressing needs such as monitoring the environment, remote medical diagnostics, advancing Australian science and technology, or monitoring for traces of explosives, this project falls directly into all four of the National Research Priorities with applications addressing corresponding Priority Goals. Other areas benefiting from the outcomes of this project will be remote monitoring of agricultural production including living species, and a number of other industries such as biotechnology, mineral processing, power generation etc.Read moreRead less
Special Research Initiatives - Grant ID: SR0354560
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
AUSTRALIAN RESEARCH NETWORK IN ANALYTICAL SCIENCE (ARNAS). The initiative will provide the foundations for the establishment of an Australian Research Network in Analytical Science (ARNAS), which will bring together fundamental researchers and practitioners working in quantitative chemical analysis and related areas. ARNAS will provide national coordination of research in analytical science, coverage of the newest developments, pooling of expertise and research facilities and resources, and rap ....AUSTRALIAN RESEARCH NETWORK IN ANALYTICAL SCIENCE (ARNAS). The initiative will provide the foundations for the establishment of an Australian Research Network in Analytical Science (ARNAS), which will bring together fundamental researchers and practitioners working in quantitative chemical analysis and related areas. ARNAS will provide national coordination of research in analytical science, coverage of the newest developments, pooling of expertise and research facilities and resources, and rapid dissemination of outcomes. ARNAS will significantly advance the national research agenda for analytical science by improving awareness of research activities and expertise, providing enhanced education and opportunities for the next generation of analytical scientists, and by stimulating new international collaborations.Read moreRead less
Self-assembled nanolayers of functionalised latexes as selective and adaptable nano-stationary phases in separation science. A new approach is proposed for the design and synthesis of functionalised ion-exchange stationary phases for analytical nano-separation methods. Desired charged functional groups are first affixed chemically onto nanometre sized latex particles and these particles are then self-assembled mechanically as monoloayer coatings onto a suitable supporting template such as fused ....Self-assembled nanolayers of functionalised latexes as selective and adaptable nano-stationary phases in separation science. A new approach is proposed for the design and synthesis of functionalised ion-exchange stationary phases for analytical nano-separation methods. Desired charged functional groups are first affixed chemically onto nanometre sized latex particles and these particles are then self-assembled mechanically as monoloayer coatings onto a suitable supporting template such as fused silica, monolithic silica or polymer beds, microfibres or microtubes, and channels in microchips. The resultant coated surface then acts as a highly efficient ion-exchange stationary phase which will be used in a wide range of separation technologies including ion chromatography, capillary electrophoresis, capillary electrochromatography and solid-phase microextraction.Read moreRead less
Separation science based on nanoparticle-coated monolithic scaffold stationary phases. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-ter ....Separation science based on nanoparticle-coated monolithic scaffold stationary phases. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-terrorism applications; environmental, clinical, and forensic analysis; energy generation and foods. The project will also lead to very significant new intellectual property having extremely high commercial potential worldwide, and thereby generates the promise of considerable direct financial returns to Australia.Read moreRead less
Integrated microfluidic device for the direct analysis of drugs and metabolites in biological fluids. Due to the way in which multiple processes are integrated in a micro Total Analysis System (µTAS), they offer substantial advantages over current technology, in terms of speed, cost of analysis, portability and operator simplicity and safety. This has considerable potential benefit for Australia, specifically for the remote and rural analysis of drugs and metabolites in biological fluids such a ....Integrated microfluidic device for the direct analysis of drugs and metabolites in biological fluids. Due to the way in which multiple processes are integrated in a micro Total Analysis System (µTAS), they offer substantial advantages over current technology, in terms of speed, cost of analysis, portability and operator simplicity and safety. This has considerable potential benefit for Australia, specifically for the remote and rural analysis of drugs and metabolites in biological fluids such as blood, serum, urine and saliva. These devices will have application for point-of-care testing in therapeutic drug monitoring, which will improve medical treatment and the patient's quality of life, as well as for on-site analysis in forensics for the rapid determination of illicit drugs and performance enhancing substances in our elite athletes.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989491
Funder
Australian Research Council
Funding Amount
$172,025.00
Summary
Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemi ....Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemistry and hydrometallurgy, aquaculture, forensic analysis, Antarctic studies, and environmental monitoring. This will directly support our work falling under National Research Priorities 1 An Environmentally Sustainable Australia, 2 Promoting and Maintaining Good Health, 3 Frontier Technologies for Building and Transforming Australian Industries, and 4 Safeguarding Australia.Read moreRead less
Synthesis, characterisation and evaluation of novel ion-exchange polymer monolithic stationary phases for separation science. This project will provide highly significant, fundamental advances in separation science by accelerating the design and development of new stationary phases and separation technologies suitable for the analysis of very complex samples. The project will lead to very significant new intellectual property having extremely high commercial potential worldwide, and therefore t ....Synthesis, characterisation and evaluation of novel ion-exchange polymer monolithic stationary phases for separation science. This project will provide highly significant, fundamental advances in separation science by accelerating the design and development of new stationary phases and separation technologies suitable for the analysis of very complex samples. The project will lead to very significant new intellectual property having extremely high commercial potential worldwide, and therefore the project has potential for considerable direct financial returns to Australia. The new technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-terrorism applications; environmental, clinical, and forensic analysis; energy generation and foods. Read moreRead less
Enhanced peak capacity in ion chromatography through gradient elution and multidimensional separations. Current methodology in ion chromatography (IC) is limited in that very complex samples cannot be analysed because the peak capacity of conventional IC systems is insufficient. The proposed research will provide a huge increase in peak capacity so that samples of extreme complexity can be analysed. Samples of this type occur in many fields, including environmental, clinical, forensic, energy ge ....Enhanced peak capacity in ion chromatography through gradient elution and multidimensional separations. Current methodology in ion chromatography (IC) is limited in that very complex samples cannot be analysed because the peak capacity of conventional IC systems is insufficient. The proposed research will provide a huge increase in peak capacity so that samples of extreme complexity can be analysed. Samples of this type occur in many fields, including environmental, clinical, forensic, energy generation and foods. The ability to directly address such samples will therefore provide benefit to a wide range of sciences of great importance to Australia. Moreover, the proposed research will lead to significant new intellectual property which can be commercialised, thereby providing further direct national benefit.Read moreRead less