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Translational Public Health Research Addressing Complex Questions In Maternal, Perinatal And Indigenous Health
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
The health of women during pregnancy and the first year after giving birth is critical to the health and well-being of children. This research aims to improve understanding of the causes and consequences of poor maternal health and contribute to better informed policy and practice in maternity, early postnatal and primary care services. It focuses on 3 major themes: improving women’s health after childbirth; maternity and early postnatal care; and Indigenous women’s and children’s health.
Validation Of The Acceptability And Reliability Of Anal Swabs Used For Cytological Screening Among HIV+ MSM
Funder
National Health and Medical Research Council
Funding Amount
$76,108.00
Summary
This study will be screening HIV-positive men who have sex with men for Anal Squamous Intra-epithelial Lesions.These lesions, if left untreated, could develop into anal cancer. The study will take anal cytology swabs from 1000 HIV-positive men who attend the HIV clinic at St Vincent's hospital. Those men who are identified as having high-grade lesions (HSIL) or atypical cells (ASCUS) will be offered follow up by the principal investigator, Dr Richard Hillman.
Exploring The Immune Landscape Of Anal Squamous Cell Carcinoma And The Therapeutic Utility Of Immunotherapies
Funder
National Health and Medical Research Council
Funding Amount
$48,791.00
Summary
Anal cancer has been on the rise without improvements in patient treatment or survival over the last three decades. Immunotherapy which uses a patient's immune system to combat cancer has demonstrated great success in the treatment of several tumours, and consequently demands investigation for patients with anal cancer. This project is focussed on examining the immune system's role in anal cancer, and whether immunotherapies can be used to improved treatment response and patient survival.
Maternal Health Study (phase 2): Longitudinal 4-year Follow-up Of A Prospective Nulliparous Pregnancy Cohort
Funder
National Health and Medical Research Council
Funding Amount
$660,402.00
Summary
The burden of disease among women after childbirth is substantial, under-recognised by health professionals, and symptoms do not necessarily resolve within the first 12 months. Common health problems after childbirth include: chronic exhaustion, back pain, urinary and faecal incontinence, perineal pain, sexual health issues and intimate partner violence. This study will extend follow-up of over 1500 women taking part in a longitudinal study investigating the physical and psychological health of ....The burden of disease among women after childbirth is substantial, under-recognised by health professionals, and symptoms do not necessarily resolve within the first 12 months. Common health problems after childbirth include: chronic exhaustion, back pain, urinary and faecal incontinence, perineal pain, sexual health issues and intimate partner violence. This study will extend follow-up of over 1500 women taking part in a longitudinal study investigating the physical and psychological health of women during pregnancy and the first 18 months after the birth of their first child. In phase 2 of the study, women will be followed up 6 and 12 months after second and subsequent births, and 4 years after the birth of their first child. A major aim of phase 2 of the study is to assess the prevalence, incidence, onset, severity, duration, recurrence and chronicity of maternal health problems (including urinary and faecal incontinence, perineal pain, sexual health issues, depression and intimate partner violence) after second and subsequent births, and 4 years after giving birth to a first child. The study will also determine the extent to which the method of birth in the first birth influences longer-term maternal health outcomes including urinary and faecal incontinence, and investigate the implications of chronic and recurring physical health problems for women's psychological health and well-being. Information on the incidence and natural history of maternal health problems after caesarean and operative vaginal births will make a major international contribution to more informed debate among clinicians, and to informing women, about the risks and benefits of increasing caesarean births. The study findings will be used to inform clinical midwifery, obstetric and primary care practice, and assist in the design of new early intervention and primary care strategies for supporting women in the early years of parenting.Read moreRead less
Sensory Innervation Of The Anal Region In Normal And Diabetic Guinea Pigs
Funder
National Health and Medical Research Council
Funding Amount
$372,389.00
Summary
Until something goes wrong, we take it for granted that we can empty our bowels on a regular basis, at a time and place of our choosing. Failure to achieve this is very distressing and substantially diminishes quality of life, if it occurs regularly. Disordered defecation, fecal incontinence and constipation are surprisingly common and their prevalence will continue to increase as our population ages and the incidence of diseases such as diabetes increases. In many people suffering these problem ....Until something goes wrong, we take it for granted that we can empty our bowels on a regular basis, at a time and place of our choosing. Failure to achieve this is very distressing and substantially diminishes quality of life, if it occurs regularly. Disordered defecation, fecal incontinence and constipation are surprisingly common and their prevalence will continue to increase as our population ages and the incidence of diseases such as diabetes increases. In many people suffering these problems, there is a detectable dysfunction of the sensory nerves in the anal region. These nerves supply information from the anal region to the spinal cord that can cause us to sense activity in our lower bowel and initiate defecation reflexes. These sensory pathways are important for clinical gastroenterology, but remarkably little is known about them. We are now able to investigate what it is the sensory nerves in the anal region sense, what they look like and where they go to in the spinal cord - in a single project. To do this we will use simple, but novel techniques that have been developed in this laboratory in an animal model. Once we know this, we will compare the function of sensory nerves in the anal region in diabetic animals with normal animals. This will give us insight into the role of sensory nerves in the development of fecal incontinence an unpleasant symptom for many people suffering advanced diabetes. My systematic approach will provide understanding of the basic cellular mechanisms and nerve pathways that underlie sensation in the anal region, helping both clinicians and patients understand the cause of defecatory disorders and potentially pointing the way to new therapies and strategies for diagnosis.Read moreRead less