Cross-comparison, Validation And Performance Of Computerised Neuropsychological Assessment Devices In The Evaluation Of Mild Cognitive Impairment And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$700,482.00
Summary
With an ageing population and associated increase in dementia there will be increased demand for neuropsychological assessment, with insufficient trained personnel and resources to meet this demand. Computerised tests offer excellent opportunities for large scale implementation of cognitive screening and monitoring of older adults. This is the first study to systematically evaluate and compare several popular computerised neuropsychological assessment devices in elders with and without dementia.
Supported Treadmill Training To Establish Walking In Non-ambulatory Patients Early After Stroke
Funder
National Health and Medical Research Council
Funding Amount
$341,349.00
Summary
This project will improve the health and well being of people affected by stroke. Stroke is the most common disabling neurological condition in adults and consumes up to 5% of health care expenditure in developed countries, estimated by the National Stroke Foundation at $1-2 billion per year in Australia. Some 48,000 people suffer a stroke each year in Australia, with approximately one third of these people requiring inpatient rehabilitation and 70% of them are unable to walk on admission to reh ....This project will improve the health and well being of people affected by stroke. Stroke is the most common disabling neurological condition in adults and consumes up to 5% of health care expenditure in developed countries, estimated by the National Stroke Foundation at $1-2 billion per year in Australia. Some 48,000 people suffer a stroke each year in Australia, with approximately one third of these people requiring inpatient rehabilitation and 70% of them are unable to walk on admission to rehabilitation. This randomised controlled trial will investigate whether treadmill walking with partial weight support via an overhead harness is effective at establishing independent walking (i) more often, (ii) earlier and (iii) with a better quality of walking, than current treatment for stroke patients who cannot walk. We will measure (i) whether patients achieve independent walking and (ii) the time taken to achieve independent walking. We will also measure parameters of walking such as speed, step length and step width to evaluate the effect of treadmill training on the quality of walking. Furthermore, by measuring participation in the community at 6 months, we will evaluate the long-term effect of this innovative treatment. Given that independence in walking is a major factor in the decision to discharge patients from inpatient care, earlier independent walking should result in a reduction in length of hospital stay which will save about $800 per patient per day in a teaching hospital setting. Identifying rehabilitation strategies which enhance walking outcome will not only improve quality of life of both stroke patients and their carers by reducing disability and handicap but also reduce the cost of rehabilitation.Read moreRead less
Media Formulations To Enhance Embryo Formation In Assisted Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$660,133.00
Summary
The increasing age of parenthood has led to an explosion in the demand for assisted reproductive technologies such as in vitro fertilisation (IVF). This procedure has a poor success rate and is limited by the ability of fertilised eggs to mature into early embryos in the lab prior to being transferred into women. We will develop new compounds that improve embryo growth in the clinic, which will improve IVF success rates.
Nicotinamide Adenine Dinucleotide (NAD+)-raising Agents For Improving Oocyte Quality
Funder
National Health and Medical Research Council
Funding Amount
$445,827.00
Summary
Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.
Effective software vulnerability detection for web services. This project aims to design and implement new and better methods to find vulnerabilities in software services delivered over the web or through the cloud, as well as methods for proving the absence of certain types of vulnerability. So-called injection attacks are pervasive and generally considered the most important security threat on today's Internet. The programming languages used for software services tend to use strings as a unive ....Effective software vulnerability detection for web services. This project aims to design and implement new and better methods to find vulnerabilities in software services delivered over the web or through the cloud, as well as methods for proving the absence of certain types of vulnerability. So-called injection attacks are pervasive and generally considered the most important security threat on today's Internet. The programming languages used for software services tend to use strings as a universal data structure, which unfortunately makes it hard to separate trusted code from untrusted user-provided data. This project intends to develop novel program analysis tools and string constraint solvers, and employ these tools to support sophisticated automated reasoning about string manipulating software.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347131
Funder
Australian Research Council
Funding Amount
$115,490.00
Summary
Intelligent Computer System to Access Information Directly from the Brain Using High Resolution Electroencephalography and Repetitive Transcranial Magnetic Stimulation. The ambitious aim of this project is to create a novel intelligent computer system which accesss information from the brain. To do this we use repetitive Transcranial Magnetic Stimulation and high resolution Electroencephalography.
Improving Global Tuberculosis Control With The AuTuMN Platform
Funder
National Health and Medical Research Council
Funding Amount
$655,059.00
Summary
Tuberculosis (TB) is the world’s leading infectious killer, with the failure of global control responsible for the vast majority of Australia’s cases. Using our robustly developed software platform, we have performed several country-level studies to predict the future burden of disease and compare the impact of alternative responses to controlling the epidemic. In this project, we will extend our platform to perform simulations at the global level and answer key questions in TB control.
An Integrative and Interactive Approach for Co-estimation of Multiple Sequence Alignment and Phylogeny Reconstruction. In this project innovative IT methods will be developed to assist biologists to solve complex and important biological problems. Many important applications in computational biology need very accurate and reliable tools for multiple sequence alignment and phylogeny reconstruction. Unfortunately, current existing tools are unreliable and are prone to serious errors when applied t ....An Integrative and Interactive Approach for Co-estimation of Multiple Sequence Alignment and Phylogeny Reconstruction. In this project innovative IT methods will be developed to assist biologists to solve complex and important biological problems. Many important applications in computational biology need very accurate and reliable tools for multiple sequence alignment and phylogeny reconstruction. Unfortunately, current existing tools are unreliable and are prone to serious errors when applied to large and divergent biological sequences. The success of this project will not only make significant contribution to the relevant research fields, but also help achieve goals in certain real-life biological research projects which are unique and important to Australia.Read moreRead less
Achieving Tailored Industrial Software Process Improvement with Experience Repositories and Electronic Process Guides. There is a well-recognised need for organisations to improve their software development processes in order to achieve higher software quality and greater efficiencies in development. The use of electronic process guides and experience repositories have been two technologies independently proposed to achieve these aims. This research will develop a framework, methods and tools ....Achieving Tailored Industrial Software Process Improvement with Experience Repositories and Electronic Process Guides. There is a well-recognised need for organisations to improve their software development processes in order to achieve higher software quality and greater efficiencies in development. The use of electronic process guides and experience repositories have been two technologies independently proposed to achieve these aims. This research will develop a framework, methods and tools to allow integration of experience repositories and electronic process guides to facilitate process tailoring, process improvement, and project management. The result will be significant improvements in software development productivity and quality.Read moreRead less
Viewable Measures for Component-Based Software Engineering. Software costs over US$300 billion per year worldwide with around 70% of large projects failing to complete in time. Reliable estimation of development effort is a great challenge in Software Engineering. This project aims to develop a reliable multi-dimensional software size measure and an effort estimation model for a new method of development called component based software engineering. We will validate our results theoretically and ....Viewable Measures for Component-Based Software Engineering. Software costs over US$300 billion per year worldwide with around 70% of large projects failing to complete in time. Reliable estimation of development effort is a great challenge in Software Engineering. This project aims to develop a reliable multi-dimensional software size measure and an effort estimation model for a new method of development called component based software engineering. We will validate our results theoretically and test it against empirical data from software industry. We will provide novel visualization techniques to comprehend measurements of large systems. The outcomes will help software projects better estimate deadlines and budgets thus reducing costs significantly.Read moreRead less