Investigating The Role Of Aberrant Splicing (intron Retention) In Acute Myeloid Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$1,135,745.00
Summary
In 2013, we made a breakthrough discovery that certain parts of genes, previously considered “Junk DNA”, are actually carrying signals to control the amount of proteins produced in cells. Our preliminary work now suggests these signals controlling protein levels can be faulty in cancers. Here, we wish to determine whether these faulty signals could cause a deadly blood cancer called acute myeloid leukaemia (AML). We aim to decipher previously unknown causes of AML that will spur novel therapies.
Intron Retention Regulation In Granulopoiesis And Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$574,419.00
Summary
Our project will shed light on the development of white blood cells, and what goes wrong when they become cancerous. In particular we have uncovered an unexpected control mechanism of gene expression in these cells. This mechanism governs the specific removal of molecules involved in transmitting information in cells (mRNAs). By extending our research to a cancer of white blood cells called chronic myeloid leukaemia, we hope to provide new insights into its causes and discover targets for innova ....Our project will shed light on the development of white blood cells, and what goes wrong when they become cancerous. In particular we have uncovered an unexpected control mechanism of gene expression in these cells. This mechanism governs the specific removal of molecules involved in transmitting information in cells (mRNAs). By extending our research to a cancer of white blood cells called chronic myeloid leukaemia, we hope to provide new insights into its causes and discover targets for innovative drugs.Read moreRead less