Perinatal Exposure To Household And Environmental Toxins And The Risk Of Asthma And Allergic Disease Up To 25 Years
Funder
National Health and Medical Research Council
Funding Amount
$291,078.00
Summary
Perinatal exposure to household and environmental toxins may increase asthma and allergic disease risk. Adverse exposures in this critical developmental window may have a marked and prolonged effect on health. A birth cohort of high-allergy risk children will be used to investigate the effect of common chemical exposures on the risk of asthma and allergic disease up to 25 years. This evidence could be used to inform guidelines on common household chemical exposures
The Role Of Infant Food Allergy In The Natural History And Burden Of Allergic Disease Across The Early Years: The HealthNuts Study
Funder
National Health and Medical Research Council
Funding Amount
$1,722,373.00
Summary
The HealthNuts study of 4600 infants is the world’s first comprehensive population-based study of food allergy with objective measurement of true food allergy and will enable us to understand better the natural history of allergic disorders including food allergy, asthma, eczema and allergic rhinitis and the interplay of risk factors for development of these conditions in the first 6 years of life. The study will have important implications for clinical guidelines and public health policy.
Prevalence Of Challenge-proven Food Allergy And Predictors Of Severe Adverse Reactions To Food In Early Adolescence: SchoolNuts
Funder
National Health and Medical Research Council
Funding Amount
$1,196,852.00
Summary
Food allergy (FA) has risen to epidemic proportions in recent times and Australia has one of the highest rates in the world. FA is most common in children under 5 years, yet adolescents are at the greatest risk of death from food-related anaphylaxis. We don’t know why this is the case. Our research will describe FA prevalence and will assess the factors placing FA adolescents at high risk of severe allergic reactions. Findings will influence policy for management of FA and anaphylaxis.
My research focuses on allergies and chronic respiratory disease in children, teenagers and adults. My goal is to identify the factors, which cause these conditions and also the factors, which can stop these conditions from getting worse. I will work with health professionals and the community to make sure the results of my research are used by doctors to improve the care of people with allergies and chronic respiratory diseases.
What Are The Lifetime Clinical Predictors And Risk Factors For Multiple Phenotypes Of Adult Asthma, COPD And Sleep Disordered Breathing? Following Up The TAHS Cohort From 1st To 6th Decade
Funder
National Health and Medical Research Council
Funding Amount
$1,950,689.00
Summary
Breathing gets impaired and impact on the productivity and quality of life when chronic respiratory diseases rise with ageing. Adult chronic respiratory diseases are major causes of illness and death but there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will provide evidence to guide health policy and clinical management of these diseases. These original findings will be of great importance both nationally and internationally.
Solving the puzzle of complex disease - genes and their interactions with the environment. Many human diseases are caused by the interplay of genetic predisposition (nature) and the environment (nurture); but their causes remain a mystery, since much past research has focused on these aspects in isolation. This project will aim to better understand these complex diseases using a multi-factorial approach that brings both nature and nurture together.