Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass a ....Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass and maximum payload, precisely targeting specific flight conditions and vehicle shapes. The prospective benefits include increased productivity and reliability and reduced cost of missions to and from space, and a proliferation of new applications which this understanding will facilitate.Read moreRead less
CD1C-LIPID-REACTIVE T CELLS. The immune system patrols our body examining molecules such as proteins and lipids that signal whether or not everything is ok. While protein recognition by the immune system is well understood, our knowledge of the fundamental features of lipid detection is poor. This project will investigate the detection of lipid molecules that are presented to the immune system in association with a molecule known as CD1c. The aims are to understand: 1. The cells that respond to ....CD1C-LIPID-REACTIVE T CELLS. The immune system patrols our body examining molecules such as proteins and lipids that signal whether or not everything is ok. While protein recognition by the immune system is well understood, our knowledge of the fundamental features of lipid detection is poor. This project will investigate the detection of lipid molecules that are presented to the immune system in association with a molecule known as CD1c. The aims are to understand: 1. The cells that respond to these lipids; 2. The cellular receptors that bind to these lipids; 3. The types of lipids involved in this process. This work is essential for us to understand lipid-based immunology which is critical if we ultimately wish to harness this to improve human health.Read moreRead less
Advancing the Science of Giant Planet Atmospheric Entry. This project aims to improve models used to design the heat shields which protect probes entering the atmospheres of the giant planets - four gaseous planets out beyond Mars. Further giant planet exploration is a key planetary science goal of the coming decade. However, the environment which an entry probe would experience features many unknowns and large uncertainties, making a mission a risky undertaking. Using unique experimental capabi ....Advancing the Science of Giant Planet Atmospheric Entry. This project aims to improve models used to design the heat shields which protect probes entering the atmospheres of the giant planets - four gaseous planets out beyond Mars. Further giant planet exploration is a key planetary science goal of the coming decade. However, the environment which an entry probe would experience features many unknowns and large uncertainties, making a mission a risky undertaking. Using unique experimental capabilities and state-of-the-art modelling, the expected project outcome is experimentally validated giant planet entry flow and surface chemistry models. This will allow more efficient heat shields to be designed while also increasing the chance of mission success, furthering our understanding of the universe.Read moreRead less
Antigen selection mechanisms control T cell immunity against bacteria. CD4+ T (T helper) cells are required to control many important bacterial infections. This Project aims to identify the key targets of CD4+ T cells responding to a model bacterial infection, and to correlate potential antigen effectiveness with native expression, antigen presentation, and the function of antigen-specific CD4+ T cells over time. Our validated experimental 'pipeline' has unprecedented potential to define potent ....Antigen selection mechanisms control T cell immunity against bacteria. CD4+ T (T helper) cells are required to control many important bacterial infections. This Project aims to identify the key targets of CD4+ T cells responding to a model bacterial infection, and to correlate potential antigen effectiveness with native expression, antigen presentation, and the function of antigen-specific CD4+ T cells over time. Our validated experimental 'pipeline' has unprecedented potential to define potent CD4+ T cell antigens within the thousands of proteins expressed by a bacterial pathogen. Our unbiased analysis may help establish the rules that define effective antigenicity. Our work will improve the understanding of bacterial immunity, and inform future design of T-cell based vaccines in the agricultural sector.Read moreRead less
Deciphering novel cross-talk between innate cytokine receptors. Understanding the basic functions of interferons, how they signal to cells, is central to understanding fundamental immunity. Interferons are crucial molecules of the immune system that are important for normal cell development and they protect the body from viral infection and cancer but can be deleterious in different autoimmune diseases and trauma settings. Preliminary Data shows there is a pathway of interferon signalling that h ....Deciphering novel cross-talk between innate cytokine receptors. Understanding the basic functions of interferons, how they signal to cells, is central to understanding fundamental immunity. Interferons are crucial molecules of the immune system that are important for normal cell development and they protect the body from viral infection and cancer but can be deleterious in different autoimmune diseases and trauma settings. Preliminary Data shows there is a pathway of interferon signalling that has previously been overlooked. This project aims to understand how this pathway works and how it contributes to the normal workings of cells. This fundamental science has future consequences for the design of vaccines and for the design of therapeutics to treat diseases that show defective interferon signalling.Read moreRead less
Next generation garbage collection: discovery, design, and development. This project aims to improve the performance of programming languages used by millions of Australians every day, such as Java, JavaScript and PHP by developing improved memory-management algorithms. These languages use what is referred to as “garbage collection” to ensure memory is managed without data loss, but do so conservatively and consequently cause performance challenges and energy overheads. This project expects to p ....Next generation garbage collection: discovery, design, and development. This project aims to improve the performance of programming languages used by millions of Australians every day, such as Java, JavaScript and PHP by developing improved memory-management algorithms. These languages use what is referred to as “garbage collection” to ensure memory is managed without data loss, but do so conservatively and consequently cause performance challenges and energy overheads. This project expects to provide these languages with improved memory-management algorithms, and provides researchers and industry with a framework for innovation. This project will enable safe software that is more efficient on today's hardware and able to exploit emerging hardware. This project should lead to better performance and energy savings for server applications, phones, watches, and smart appliances, while ensuring memory safety.Read moreRead less
Magnetohydrodynamic Aerobraking for Spacecraft Entry to Earth's Atmosphere. A spaceship returning from Mars will undergo unprecedented aerodynamic heating as it enters Earth's atmosphere. Magnetohydroynamic aerobraking involves applying a strong magnetic field to the plasma which forms around the spacecraft at these speeds, theoretically protecting it by reducing structural heat loads and enabling less severe flight trajectories. This project aims to experimentally study this technology for Eart ....Magnetohydrodynamic Aerobraking for Spacecraft Entry to Earth's Atmosphere. A spaceship returning from Mars will undergo unprecedented aerodynamic heating as it enters Earth's atmosphere. Magnetohydroynamic aerobraking involves applying a strong magnetic field to the plasma which forms around the spacecraft at these speeds, theoretically protecting it by reducing structural heat loads and enabling less severe flight trajectories. This project aims to experimentally study this technology for Earth return from deep space. It is significant because it will evaluate a new mechanism for managing the tremendous heat loads of planetary entry. The expected outcome and benefit will be development of a new technology to reduce spacecraft heating, leading to safer, more efficient, and potentially reusable spacecraft.Read moreRead less
Control of immune recognition and response by microbial metabolites. This project aims to study immune recognition of microbial metabolites and develop reagents to control immune responses. Chemical synthesis will be used to develop new antigens for unconventional T cells and the first soluble agonists and antagonists of a glycolipid-sensing immune receptor. Expected outcomes include the discovery of new immune effectors, broadening our knowledge of the repertoire of small molecules that can be ....Control of immune recognition and response by microbial metabolites. This project aims to study immune recognition of microbial metabolites and develop reagents to control immune responses. Chemical synthesis will be used to develop new antigens for unconventional T cells and the first soluble agonists and antagonists of a glycolipid-sensing immune receptor. Expected outcomes include the discovery of new immune effectors, broadening our knowledge of the repertoire of small molecules that can be sensed by the immune system, and developing chemical approaches to promote or dampen immune responses. Major benefits include research training in chemical biology, strengthened international linkages and fundamental insights into the chemical basis of immune recognition and response.Read moreRead less
Linear Formation Interferometry for Astrophysics and New Space Technologies. This project will prototype a new type of visible and infrared light interferometry: telescopes freely moving in a line 10s of metres in length and directing their light towards a central beam combiner. This is particularly well suited to sparse aperture optical interferometry from space, which can be used to resolve angular scales much finer than the world's largest monolithic telescopes. The ground based prototype wil ....Linear Formation Interferometry for Astrophysics and New Space Technologies. This project will prototype a new type of visible and infrared light interferometry: telescopes freely moving in a line 10s of metres in length and directing their light towards a central beam combiner. This is particularly well suited to sparse aperture optical interferometry from space, which can be used to resolve angular scales much finer than the world's largest monolithic telescopes. The ground based prototype will also be able to make a several key astrophysical observations of benchmark stars and stellar systems, including making precise polarimetric measurements of dust shells around bright stars.Read moreRead less
Differentiation of effector and tissue regulatory T cells . Regulatory T cells (Tregs) populate almost every organ of the body and play a central role in preventing inflammation and maintaining health. To exercise these functions, Tregs undergo a developmental program, the details of which are poorly known. This project will utilize newly developed biological tools and state-of-the-art technology to uncover the molecular mechanisms that govern Treg development and function. The project will gene ....Differentiation of effector and tissue regulatory T cells . Regulatory T cells (Tregs) populate almost every organ of the body and play a central role in preventing inflammation and maintaining health. To exercise these functions, Tregs undergo a developmental program, the details of which are poorly known. This project will utilize newly developed biological tools and state-of-the-art technology to uncover the molecular mechanisms that govern Treg development and function. The project will generate basic scientific knowledge and new intellectual property that will afford new opportunities for research and development. The outcomes of this project will help to devise strategies to treat diseases such as autoimmunity, cancer and metabolic syndrome, and will thus benefit veterinary and human health.Read moreRead less