A Population-based Longitudinal Assessment Of Early Life Vitamin D And Risk Of Food Allergy
Funder
National Health and Medical Research Council
Funding Amount
$466,086.00
Summary
There has been a dramatic and unexplained increase in food allergy over recent decades. The increase in food allergy may relate to a concordant increase in early vitamin D insufficiency, however this hypothesis has never been directly tested. This project will use existing/funded samples from two NHMRC funded studies to conduct a detailed investigation of (i) the determinant and predictors of early life vitamin D insufficiency; and (ii) the association of vitamin D insufficiency and food allergy ....There has been a dramatic and unexplained increase in food allergy over recent decades. The increase in food allergy may relate to a concordant increase in early vitamin D insufficiency, however this hypothesis has never been directly tested. This project will use existing/funded samples from two NHMRC funded studies to conduct a detailed investigation of (i) the determinant and predictors of early life vitamin D insufficiency; and (ii) the association of vitamin D insufficiency and food allergy.Read moreRead less
Developing And Evaluating A Multimodal Antibiotic Allergy Strategy To Improve Antimicrobial Stewardship In High-risk Antibiotic Usage Populations
Funder
National Health and Medical Research Council
Funding Amount
$303,014.00
Summary
Antibiotic allergies lead to the use of inferior antibiotics and generation of “superbugs”. Antibiotic allergy testing removes up to 90% of allergies, although remains unavailable to many and unreliable in some severe antibiotic reactions. We aim to validate antibiotic allergy bedside tools and programs, and develop laboratory tests that can diagnose and prevent severe antibiotic allergies, to improve appropriate antibiotic prescribing and patient outcomes.
The Long-term Consequences Of Assisted Reproduction On The Growth, Metabolic, Respiratory, Psychological, Immunological And Reproductive Development Of The Offspring.
Funder
National Health and Medical Research Council
Funding Amount
$1,552,096.00
Summary
1 in 25 children are born from IVF treatment - incredibly- to our shame; no data exists as to the long-term health of these children. Presented is a unique opportunity, which would be exceedingly difficult to replicate elsewhere in the world, to determine the long-term consequences of IVF upon the development of the offspring, by comparing their growth, metabolic, respiratory, psychological, immunological and reproductive development to a representative sample of WA children- the Raine cohort.
The aim of this proposal is to test the safety of a novel immunotherapy based on Helicobacter pylori platform technology to treat childhood allergies. Repeated oral administration of killed H. pylori mimics colonisation in the stomach and assists the development of a balanced immune system without the associated disease risk of live H. pylori. To achieve this goal Professor Barry Marshall has assembled a cross-disciplinary team of experts from Industry, Academia and Clinic.
Population Prevalence And Environmental-genetic Predictors Of Food Allergy In An Infant Cohort
Funder
National Health and Medical Research Council
Funding Amount
$551,642.00
Summary
This study will measure which children are at greatest risk of food allergy. We plan to recruit 5000 children to test for food allergies, as well as asking a range of questions on different lifestyle factors such as diet and history of allergies . If positive, participants will be invited to a hospital clinic for tests and treatment. This will allow us to describe the epidemiology of food allergy, and assist the development of better services for those with food allergy in the community.
Designing new generation adjuvants for allergy and parasite vaccines. Allergy vaccines have the potential to provide a permanent cure against many allergic diseases, currently affecting 20-30 per cent of people in developed countries. This project will study how allergy vaccines work and how we can improve their effectiveness and safety.
Centre Of Research Excellence In Eradicating Food Allergy: Prevention, Cure And Reducing Adverse Events
Funder
National Health and Medical Research Council
Funding Amount
$2,496,041.00
Summary
Australia has the highest reported rate of food allergy in the world. We aim to eradicate food allergy through improved prevention and cure, supported by evidence generated by our collaborative network of research. In addition, we aim to help prevent children with food allergy having anaphylaxis through improved public health policy and clinical pathways. As a second wave of the allergy epidemic, we are well positioned to turn back the tide of this newly emergent health threat to the public.
Discovery Early Career Researcher Award - Grant ID: DE240100040
Funder
Australian Research Council
Funding Amount
$442,302.00
Summary
Quality Assurance of Mobile Applications by Effective Testing and Repair. This project aims to create advanced techniques that will enable software engineers to effectively develop quality assured and robust software systems. This project expects to generate new and innovative approaches that automate software testing and repair. The expected outcomes of this project include new knowledge of software engineering, development of an automated and cost-effective testing system with improved coverag ....Quality Assurance of Mobile Applications by Effective Testing and Repair. This project aims to create advanced techniques that will enable software engineers to effectively develop quality assured and robust software systems. This project expects to generate new and innovative approaches that automate software testing and repair. The expected outcomes of this project include new knowledge of software engineering, development of an automated and cost-effective testing system with improved coverage, greater bug detection and repair, and faster testing protocols. This should provide significant benefits to software users by providing reliable and user-friendly systems and to software companies to position Australia as a global leader in software development and technological advancement.Read moreRead less
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
The Impact Of Outdoor Aeroallergen Exposure On Asthma Exacerbations In Children And Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$473,924.00
Summary
Asthma is a chronic condition usually diagnosed in childhood and an important public health concern. We do not fully understand what triggers an asthma attack, although outdoor pollen and moulds may be important. This project will establish the relative importance of pollen and moulds in triggering asthma attacks among Australian children. It will fill gaps in our knowledge of environmental triggers of asthma. Such knowledge will improve asthma management and ultimately public health.