Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease. Rhinovirus (RV) infections account for around 90 per cent of asthma exacerbations, yet the mechanisms behind this are unknown. This project will use mouse models to study the effects of early life RV infection and allergic sensitisation on respiratory and immunological development, with the expectation that early life RV infection disrupts anitgen presenting cell function.
Radiation and Ablation in Rapidly Expanding Flows. The aim of the project is to record the spectra of radiation from a region of rapidly expanding flow representative of the passage of the shock layer on a re-entry capsule from the windward to the leeward surfaces. The significance of this work is that it addresses a critical area of spacecraft where the uncertainties of our design techniques are of the order of 300 per cent in terms of surface heat transfer, and current vehicles have to use lar ....Radiation and Ablation in Rapidly Expanding Flows. The aim of the project is to record the spectra of radiation from a region of rapidly expanding flow representative of the passage of the shock layer on a re-entry capsule from the windward to the leeward surfaces. The significance of this work is that it addresses a critical area of spacecraft where the uncertainties of our design techniques are of the order of 300 per cent in terms of surface heat transfer, and current vehicles have to use large safety factors to ensure survivability. The outputs from the project will be a data base of radiative parameters which should enable accurate models of the flow to be developed, which is expected to facilitate the design of advanced spacecraft with greater safety and reliability, and with lower structural mass.Read moreRead less
Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass a ....Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass and maximum payload, precisely targeting specific flight conditions and vehicle shapes. The prospective benefits include increased productivity and reliability and reduced cost of missions to and from space, and a proliferation of new applications which this understanding will facilitate.Read moreRead less
Turbulent heat transfer during Mars Venus and Earth atmospheric entry. This project aims to design better heat shields for spacecraft. Designing heat shields for re-entry vehicles needs good models to predict aerodynamic heating. Conventional wind tunnels cannot measure aerodynamic heating in ground tests in the region of peak heating, making design uncertain and risky. This project will use a free-piston-driven expansion tunnel that can produce flows fast and dense enough to measure heating for ....Turbulent heat transfer during Mars Venus and Earth atmospheric entry. This project aims to design better heat shields for spacecraft. Designing heat shields for re-entry vehicles needs good models to predict aerodynamic heating. Conventional wind tunnels cannot measure aerodynamic heating in ground tests in the region of peak heating, making design uncertain and risky. This project will use a free-piston-driven expansion tunnel that can produce flows fast and dense enough to measure heating for turbulent boundary layers at the highest speeds encountered during re-entry. This should allow scientists to test and develop theoretical and numerical models of heating and so improve spacecraft design.Read moreRead less
Sterile inflammation as a determinant of adaptive immunity. When we injure ourselves, the site of injury becomes inflamed, which may help healing or cause trouble. This project aims to understand how the normal response to injury is controlled and why the process may sometimes go wrong.
Ablative thermal protection systems. The project will study ablative reentry heat shields by experiments simulating hypervelocity atmospheric flight. The results will enable the design of the advanced spacecraft which are needed to extend mans exploration of the universe. Data will be validated by comparison with flights such as the Japanese Hayabusa asteroid sample return mission.
The science of scramjet propulsion. This project will study the science of scramjet operation at high Mach numbers and develop the understanding required for operation at such conditions. The outcomes include experimentally validated scramjet models operating at speeds never reached before, and the potential to extend the known flight envelope for air breathing propulsion.
Advancing the Science of Giant Planet Atmospheric Entry. This project aims to improve models used to design the heat shields which protect probes entering the atmospheres of the giant planets - four gaseous planets out beyond Mars. Further giant planet exploration is a key planetary science goal of the coming decade. However, the environment which an entry probe would experience features many unknowns and large uncertainties, making a mission a risky undertaking. Using unique experimental capabi ....Advancing the Science of Giant Planet Atmospheric Entry. This project aims to improve models used to design the heat shields which protect probes entering the atmospheres of the giant planets - four gaseous planets out beyond Mars. Further giant planet exploration is a key planetary science goal of the coming decade. However, the environment which an entry probe would experience features many unknowns and large uncertainties, making a mission a risky undertaking. Using unique experimental capabilities and state-of-the-art modelling, the expected project outcome is experimentally validated giant planet entry flow and surface chemistry models. This will allow more efficient heat shields to be designed while also increasing the chance of mission success, furthering our understanding of the universe.Read moreRead less
Convergence of biomaterials and immunology: a technology platform for delayed burst release of vaccines. A large challenge in vaccination, particularly in wildlife such as for the growing problem of Chlamydia in koalas, is to provide the necessary booster shots. This project will develop implants that will be inserted under the skin at the time of the first shot, and will spontaneously burst later to release the booster shot to provide protection.
SNARE-mediated perforin and cytokine release in natural killer cells. Cytotoxic cells release toxic granules and cytokine messengers to kill pathogen infected and cancerous cells and to mount immune responses. This project will investigate different SNARE molecules that regulate the secretion of perforin from granules and cytokines from other carriers, assisting in the understanding of complex but essential cellular pathways.