Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model ....Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model of phylogenetic branching,
analyses of nucleic acid structure and content (spin chain models of
RNA binding and of DNA open reading frames), and insights into the
origin of the code itself (via numerical codon similarity measures).
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Viscous Effects in Free-Surface Flows. Australia has a proud record of achievement in the field of free-surface fluid mechanics. This project will build and extend these research achievements. It will provide new information about how fluid layers overturn and mix, which is an important process in oceanography. It will examine the sloshing behaviour of fluid in moving storage tanks, which is important in fuel transport and building design. The project will develop new mathematical methods fo ....Viscous Effects in Free-Surface Flows. Australia has a proud record of achievement in the field of free-surface fluid mechanics. This project will build and extend these research achievements. It will provide new information about how fluid layers overturn and mix, which is an important process in oceanography. It will examine the sloshing behaviour of fluid in moving storage tanks, which is important in fuel transport and building design. The project will develop new mathematical methods for solving these problems accurately, and will contribute to the next generation of research mathematicians in Australia. Read moreRead less
Markov invariants and phylogenetic tree reconstruction. The project will assist Australia to progress as an innovator in the production phylogenetic tree reconstruction techniques.
Identifying species is a difficult task with environmental, social and economic benefits to Australia. DNA evidence and phylogenetic methods clearly achieve this task. Conservation of rare species depends upon identification and hence robust phylogenetic analysis. Phylogenetically identifying fish species has econom ....Markov invariants and phylogenetic tree reconstruction. The project will assist Australia to progress as an innovator in the production phylogenetic tree reconstruction techniques.
Identifying species is a difficult task with environmental, social and economic benefits to Australia. DNA evidence and phylogenetic methods clearly achieve this task. Conservation of rare species depends upon identification and hence robust phylogenetic analysis. Phylogenetically identifying fish species has economic importance as different fish species are all managed separately, having different catch limits, catch areas and market values. Using effective phylogenetic methods, epidemiologists can track the spread of a disease through a population. Read moreRead less
Advanced matrix-analytic methods with applications. Over the last twenty-five years, matrix-analytic methods have proved to be very successful in formulating and analysing certain classes of stochastic models. Motivated by applications, this project will investigate more advanced matrix-analytic methods than have hitherto been studied.
Algebraically informed models of biological sequence evolution. To make sense of the patterns they see in the natural world, biologists across fields as diverse as genetics, epidemiology and biogeography need an accurate picture of evolutionary history. DNA sequences provide an exciting means to establish this picture of the past, but to decode it successfully requires mathematical models of how DNA evolves. Mathematical inconsistencies have been identified with current approaches. In particular ....Algebraically informed models of biological sequence evolution. To make sense of the patterns they see in the natural world, biologists across fields as diverse as genetics, epidemiology and biogeography need an accurate picture of evolutionary history. DNA sequences provide an exciting means to establish this picture of the past, but to decode it successfully requires mathematical models of how DNA evolves. Mathematical inconsistencies have been identified with current approaches. In particular, understanding the effect of natural selection in different parts of the tree of life requires models that behave robustly in the face of shifting evolutionary processes. This project aims to use insights from algebraic methods to construct mathematically consistent models of wide biological utility.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100423
Funder
Australian Research Council
Funding Amount
$369,061.00
Summary
Group theory and phylogenetics: exploiting symmetry to uncover evolutionary history. Using advanced algebra, structural symmetries inherent in phylogenetic methods will be studied and improved approaches will be derived. DNA sequences contain a wealth of information about evolutionary events that occurred millions of years ago, but extracting this information requires the application of robust methods.
Wave slam on high speed wave piercing catamaran ferries in large seas. Australia has taken a pioneering lead in the design of high speed multi-hull ferries and continues to extend their speed, range and payload performance. Design leadership and the technology which supports it are crucial to maintaining the existing large share of the international market for such vessels. Recently freight and military transport vessels have been exposed to much more severe wave conditions than passenger vessel ....Wave slam on high speed wave piercing catamaran ferries in large seas. Australia has taken a pioneering lead in the design of high speed multi-hull ferries and continues to extend their speed, range and payload performance. Design leadership and the technology which supports it are crucial to maintaining the existing large share of the international market for such vessels. Recently freight and military transport vessels have been exposed to much more severe wave conditions than passenger vessels and this has increased the need for improved prediction of structural loads due to waves. This project directly addresses that need by computation and model testing validation. The industry is a significant export earner and employer within Australia and so the project directly underpins those national benefits. Read moreRead less
Asymmetric and nonlinear unsteady loads on high speed ferries. Large high speed catamarans are expanding their domain of application from coastal passenger routes to ocean freight and military service. This is shifting operability criteria from motions and passenger discomfort to structural load limitations in severe wave environments. This project investigates large wave structural load prediction. Large waves lead to strongly non-linear responses, invalidating many methods of analysis. Predict ....Asymmetric and nonlinear unsteady loads on high speed ferries. Large high speed catamarans are expanding their domain of application from coastal passenger routes to ocean freight and military service. This is shifting operability criteria from motions and passenger discomfort to structural load limitations in severe wave environments. This project investigates large wave structural load prediction. Large waves lead to strongly non-linear responses, invalidating many methods of analysis. Prediction of loads on the transverse structure is also not possible with many prediction methods. This project will develop and validate by experiment fully time domain computational methods for the prediction of asymmetric structural loads due to large wavesRead moreRead less
An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will r ....An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will rectify this situation by using representation theory to transform combinatorial group theory into linear algebra, allowing for the application of advanced methods of numeric approximation. This will provide a better understanding of how bacteria evolve and improve our ability to manage their impact.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100082
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Australasian facility for the automated fabrication of high performance bespoke components. A facility for the automated fabrication of high performance bespoke components: The project will create a new coordinated facility for composites research including modern automated infrastructure. The facility will bring Australia in line with leading international research centres and promote fundamental and applied research into a range of fields including underwater renewable energy systems, space ....An Australasian facility for the automated fabrication of high performance bespoke components. A facility for the automated fabrication of high performance bespoke components: The project will create a new coordinated facility for composites research including modern automated infrastructure. The facility will bring Australia in line with leading international research centres and promote fundamental and applied research into a range of fields including underwater renewable energy systems, space vehicle structures, multifunctional and smart materials and infrastructure capacity extension. The facility will position Australian research for significant international collaboration through endorsement of next-generation manufacturing technology and enable leading outcomes for Australasian science and engineering in aerospace, marine, civil, automotive, renewable energy and primary resources.Read moreRead less