Quantifying The Predictors And Risks Of Problematic Alcohol Use
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
This Fellowship will identify the health outcomes, pathways to disability and death, and risk and protective factors for these harms among people with alcohol problems. Projects will include a longitudinal study of people with existing alcohol problems, a longitudinal study of adolescent emerging alcohol consumers, and a field study of alcohol problems in night-time entertainment areas. Findings will inform standardised alcohol screening and intervention and expansion of alcohol treatment.
Defining The Clinical Role Of Topiramate In The Treatment Of Alcohol Dependence In Australia
Funder
National Health and Medical Research Council
Funding Amount
$718,836.00
Summary
We urgently require new strategies for the treatment of alcohol dependence. The effectiveness of currently approved alcohol medications is limited. Emerging data suggests that topiramate has robust effectiveness and that better medicine selection is possible for patients based on their genotype. We propose to conduct a double-blind randomised controlled trial to examine the clinical and cost effectiveness of topiramate using a genetically based personalised approach.
Parental Supply Of Alcohol To Children: Associations With Early Adult Health – “binge” Drinking, Alcohol-related Harms, Aggression, And Alcohol Use Disorders
Funder
National Health and Medical Research Council
Funding Amount
$1,143,477.00
Summary
We will investigate of the impacts of parental supply of alcohol between 13-18 years, on early adult alcohol use (19-23 years). We will follow an existing cohort of ~1,810 parent-child dyads, and assess the development of alcohol use, disorders, harms and aggression. We will investigate the impacts of: parental supply of sips vs drinks; supervised vs unsupervised supply; and modifying effects of contexts of supply and mediators (such as peer, child factors, etc.) controlling for confounders.
Reducing The Burden Of Disease Due To Hazardous Alcohol Consumption
Funder
National Health and Medical Research Council
Funding Amount
$652,765.00
Summary
I am a behavioural scientist interested in the causes and prevention of hazardous alcohol consumption. I propose a program of research examining methods in behavioural science, risk factors for hazardous drinking, the development and evaluation of interventions to reduce hazardous drinking, and the evaluation of policies affecting the supply and promotion of alcohol. I lead a research team with strong collaborations with leading scientists in Australia and other countries.
Unraveling The Neural Circuitry Of Context-induced Relapse To Alcohol Seeking After Punishment-imposed Abstinence
Funder
National Health and Medical Research Council
Funding Amount
$528,016.00
Summary
Alcohol use disorder (alcoholism) causes significant social and economic costs to Australian society. Alcoholism is a brain disease, and relapse during abstinence is the main problem in successful treatment. In this project, we use an animal model of relapse to alcohol seeking after abstinence imposed by a negative consequence (punishment). This project will identify brain regions which can be targeted in future clinical studies in human alcoholics.
Acute And Chronic Effects Of Alcohol On Sleep And Sleep Related Brain Functioning In Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$302,123.00
Summary
Excessive alcohol consumption is associated with increased risk of physical injury and risky sexual behaviour, particularly in adolescence and young adulthood. Little is known about alcohols impact on brain activity during sleep in this age group. This project investigates whether brain synchronisation during sleep is an early marker of alcohol related brain damage in late adolescence and if acute intoxication disrupts sleep related memory processes during this critical developmental period
Enhancing Extinction Of Alcohol-Predicitve Stimuli Through Modulation Of Noradrenergic Signaling
Funder
National Health and Medical Research Council
Funding Amount
$374,508.00
Summary
A major obstacle for alcohol-abuse treatment is the high risk of relapse and stimuli previously paired with alcohol use contribute importantly to this risk. Reducing the ability of such stimuli to trigger alcohol-seeking behaviors could significantly improve treatment outcomes. The experiments in the current proposal will develop both behavioral and pharmacological strategies for improving extinction learning with the long term goal of reducing the ability of stimuli to elicit alcohol-seeking.
Randomised Controlled Trial Of Treatment For Alcohol Use Problems And Social Phobia
Funder
National Health and Medical Research Council
Funding Amount
$630,333.00
Summary
Social Phobia and harmful Alcohol use often go together and suferers experince additional distress, disability, and worse results from treatment. Previous clinical trials tested adding treatments for the separate disorders together which may have confused patients. This project test integrated evidence based CBT treatments for the separate problems compared to treatment for alcohol alone. Reduced drinking, decreased social anxiety and increased quality of life are the expected results
I am a psychologist who leads an internationally recognised program of research which aims to increase our understanding of alcohol and drug problems, prevent them where possible and improve treatment responses.
Understanding Sex Differences In Alcohol Use Disorder: The Role Of Stress And Neuropeptides
Funder
National Health and Medical Research Council
Funding Amount
$692,106.00
Summary
Alcohol use disorders (AUD) are an emerging issue in women, yet there is little understanding of the how the male and female brains differ in response to excessive alcohol consumption. In pilot studies, we have found that deletion of a specific brain chemical causes differences in the way male and female mice consume alcohol in excess. We will further characterise this system and test new approaches to reduce the desire to consume alcohol.