Driving Under The Influence Of Psychoactive Prescription Benzodiazepines And Alcohol
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Driving enables people to travel to work and social events, and is thus an important determinant of quality of life. Driving is also a potentially dangerous activity, as there is a risk of becoming involved in accidents. In fact, car accidents are one of the leading causes of injury and death. Whilst alcohol remains the most prevalent drug causing impairment of driving performance, other drugs, especially in combination with alcohol, are thought to increase collision risk.
Tolerance Induction By Antigen-presenting Cell-targeted Antigen
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
We have found that by ‘targeting’ antigen to the cells that ‘train’ the immune system we have been able to prevent the development of autoimmune disease. In the research proposed here we aim to develop new ways in which antigens can be targeted to these cells so that this approach can be applied clinically. The proposed studies will also determine how antigens targeted in this way restore self-tolerance and prevent autoimmune disease.
Understanding The Etiology Of Psychiatric Disorders Through Whole Genome Analyses
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
Psychiatric disorders exert a huge social and economic burden on society. In recent years, large genetic studies have led to important new insights into these disorders. Major new human genomics resources will soon become available. My research will take advantage of these datasets to investigate the genetic basis of key epidemiological features of psychiatric disorders, including risk due to parental age and sex-biased prevalence, and to identify novel risk genes for schizophrenia and autism.
Statistical Methods For Identifying Genes Involved In Common Complex Disease
Funder
National Health and Medical Research Council
Funding Amount
$307,232.00
Summary
Better understanding of the genetic component of common diseases (e.g. melanoma, psychiatric disorders) is likely to lead to improved public health. Identification of disease susceptibility loci is currently one of the primary means for increasing our understanding of the biochemical and developmental pathways involved in many common diseases. This application will focus on developing new statistical genetic methods to better understand genetic variation and to allow more effective gene mapping.
Reducing The Injury And Disease Burden Attributable To Alcohol: Methodological, Aetiological And Intervention Studies.
Funder
National Health and Medical Research Council
Funding Amount
$408,412.00
Summary
The research examines the influence of individual, social and environmental factors on drinking behaviour, and seeks to determine the effectiveness of strategies to prevent alcohol-related harm, with a particular focus on youth drinking. A series of studies is proposed, examining the validity of methods for measuring drinking behaviour; social and environmental factors, and interventions. The findings will have relevance to reducing the burden of alcohol-related injury and disease in Australia.
Understanding And Preventing Population-level Harm From Alcohol
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
This project will support Dr Livingston's world-leading work to better understand the reasons that alcohol consumption and related-harm changes at the population level. It will also support projects that will directly assess the impact of changes to alcohol policies in Australia and the development of policy simulation models, to provide critical evidence and ensure well-informed policy decisions can be made to reduce alcohol-related harm.
Alcohol-related harm is a major contributor to the total burden of disease and social problems experienced both globally and in Australia. Considerable burden is placed on health and policing sectors and at substantial financial cost. This project will significantly improve Australian capacity to monitor alcohol related harms at local, state and national levels, enhance the underlying epidemiology and understanding of relations between alcohol and harm and enable reliable and timely evaluation o ....Alcohol-related harm is a major contributor to the total burden of disease and social problems experienced both globally and in Australia. Considerable burden is placed on health and policing sectors and at substantial financial cost. This project will significantly improve Australian capacity to monitor alcohol related harms at local, state and national levels, enhance the underlying epidemiology and understanding of relations between alcohol and harm and enable reliable and timely evaluation of alcohol policy.Read moreRead less