Promoting Responsible Drinking Practices To Drinkers To Reduce The Risk Of Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$271,476.00
Summary
Australians are heavy drinkers by world standards, which places them at risk of a wide range of alcohol-related harms. Broad-based interventions are needed to address a heavy drinking culture that involves regular engagement in heavy episodic drinking. This study will use a multi-method approach to develop and test messages that can be used to encourage enactment of responsible drinking practices that can reduce total alcohol intake and discourage binge drinking consumption patterns.
Driving Under The Influence Of Psychoactive Prescription Benzodiazepines And Alcohol
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Driving enables people to travel to work and social events, and is thus an important determinant of quality of life. Driving is also a potentially dangerous activity, as there is a risk of becoming involved in accidents. In fact, car accidents are one of the leading causes of injury and death. Whilst alcohol remains the most prevalent drug causing impairment of driving performance, other drugs, especially in combination with alcohol, are thought to increase collision risk.
Can Pharmacotherapy Prevent Alcohol Driven Suicides?
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
In Australia, suicide is the leading cause of death for young people and the 5th highest for people in their middle age. Harmful use of alcohol can be attributed to around a third of suicides, and there is evidence that alcohol related suicides represent a clinically distinct type of suicide. This research aims to identify medications that have the potential prevent alcohol related suicides by targeting behaviours associated with alcohol use.
Alcohol Consumption And Health Inequalities - The Role Of Alcohol Policy
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
This fellowship will fund a program of work examining the contribution of alcohol consumption and related harm to socioeconomic inequalities in Australian's health. A particular focus will be on the role of alcohol policy in perpetuating or reduction health inequalities. The fellowship will involve the collection of new and important data and the use of innovative analytical approaches to explore these issues.
The Relationship Between Accident Culpability And Drug Presence In Blood Samples Taken From Persons Injured In Motor Vehicle Collisions.
Funder
National Health and Medical Research Council
Funding Amount
$200,721.00
Summary
This project aims to determine the incidence of drugs in blood samples taken under the Victorian Road Safety Act 1986 from drivers involved in non-fatal collisions, the relative importance of illicit drugs, legal drugs used as prescribed, and legal drugs misused by drivers in non-fatal collisions by examining driver culpability in these accidents.
Reducing Alcohol-related Harm In Rural Communities
Funder
National Health and Medical Research Council
Funding Amount
$265,000.00
Summary
In 1992 in Australia, there were an estimated 3,660 alcohol-related deaths and 71,593 alcohol-related hospital episodes, resulting in a total economic cost of $4,031.9 million, 84% of which was avoidable. In 1998, about half of all males and a third of all females drank at least once a month at levels that placed them at risk of harm. In NSW, alcohol was estimated as being a causal factor in about one-quarter of all road traffic deaths in 1995 and was associated with a 58% increase in hospital u ....In 1992 in Australia, there were an estimated 3,660 alcohol-related deaths and 71,593 alcohol-related hospital episodes, resulting in a total economic cost of $4,031.9 million, 84% of which was avoidable. In 1998, about half of all males and a third of all females drank at least once a month at levels that placed them at risk of harm. In NSW, alcohol was estimated as being a causal factor in about one-quarter of all road traffic deaths in 1995 and was associated with a 58% increase in hospital utilistion rates between 1988-89 and 1990-91. The burden of suffering appears disproportionately higher in rural areas of NSW: per capita rate of convictions associated with a prescribed alcohol concentration in rural towns was approximately double that in metropolitan areas in 2000. The rate of attendances at hospital accident and emergency departments was also higher in rural areas. These data suggest a need for additional effort to reduce alcohol-related harm in rural, relative to metropolitan, areas. In Australia, there have been no well-controlled, community-based, attempts to reduce alcohol-related harm by simultaneously implementing a range of interventions. The conduct of a large-scale randomised controlled trial (RCT) to investigate the effectiveness of this approach is difficult to justify, due to the substantial costs associated with such a rigorous design. However, a less rigorus, though equally valid, design, such as a stepped wedged approach, would likely provide good evidence to justify the subsequent conduct of an RCT. If the expected outcomes are not achieved, the conduct of an RCT can be postponed until reasonable preliminary evidence regarding the types of community-based interventions most likely to be effective is obtained. In either case, this study will provide valuable information as to which community-based interventions, and in what combination, are most likely to reduce the occurrence of alcohol-related harm in rural communities in Australia.Read moreRead less
I am a neuroscientist, studying fundamental mechanisms related to addiction. A major feature of my research is the neuropharmacological characterisation of potential novel therapeutic strategies to combat drug-seeking behaviour
Fine Mapping Of The ADH Region For Alcohol Metabolism, Use And Dependence
Funder
National Health and Medical Research Council
Funding Amount
$215,690.00
Summary
It is widely known that alcohol use and alcohol dependence can cause many social problems and morbidity. We know that social and and cultural factors can affect the possibility of becoming alcohol dependent. We also know that inheritance plays a major role in the risk of becoming dependent upon alcohol. Two inherited causes or genes have already been identified as causing some people to avoid alcohol and so have less chance of becoming dependent upon it. Clues as to why this happens come from wh ....It is widely known that alcohol use and alcohol dependence can cause many social problems and morbidity. We know that social and and cultural factors can affect the possibility of becoming alcohol dependent. We also know that inheritance plays a major role in the risk of becoming dependent upon alcohol. Two inherited causes or genes have already been identified as causing some people to avoid alcohol and so have less chance of becoming dependent upon it. Clues as to why this happens come from what happens to alcohol following a drink. The body detoxifies itself of alcohol in the liver. There it is converted to very highly toxic acetaldehyde and this is normally rapidly removed by a protein called aldehyde dehydrogenase. Some people do not have a normally functioning form of this protein and cannot remove the acetaldehyde from their bodies. They suffer unpleasant side effects such as nausea, facial flushing and sickness. Consequently they learn by experience to avoid alcohol use and are less likely to develop dependence. We now know that even people with a normally inherited form of aldehyde dehydrogenase can have a lowered risk of dependence. The rate at which our livers convert alcohol to actetaldehyde is also a key factor. Those who are inherently quick at this process again learn to avoid alcohol, others are more at risk. The hypothesis will be tested with a unique set of twins who have provided us with detailed information on how quickly they detoxify alcohol and of their drinking habits for over 20 years. Collectively they will enable us to determine if there is a major genetic influence on alcohol use and dependence that is caused by inter-individual differences in a gene for alcohol metabolism. The DNA of these twins will be used to locate mutations that we predict have a common effect upon our measures of alcohol detoxification, drinking habits and risk of alcoholism.Read moreRead less
Unraveling The Neural Circuitry Of Context-induced Relapse To Alcohol Seeking After Punishment-imposed Abstinence
Funder
National Health and Medical Research Council
Funding Amount
$528,016.00
Summary
Alcohol use disorder (alcoholism) causes significant social and economic costs to Australian society. Alcoholism is a brain disease, and relapse during abstinence is the main problem in successful treatment. In this project, we use an animal model of relapse to alcohol seeking after abstinence imposed by a negative consequence (punishment). This project will identify brain regions which can be targeted in future clinical studies in human alcoholics.
Single-focussed Versus Integrated Cognitive Behaviour Therapy For Co-occurring Depression And Alcohol Use Problems
Funder
National Health and Medical Research Council
Funding Amount
$777,500.00
Summary
This study is significant and timely in that it proposes a large-scale randomised controlled trial of cognitive behaviour therapy (CBT) for people with co-occurring depression and alcohol use problems. To date, very few researchers have conducted research within this population, whose complex presentation makes it difficult for treatment providers to select and deliver effective treatment programs. Thus, although rates of depressive disorders and alcohol use problems are on the increase in our c ....This study is significant and timely in that it proposes a large-scale randomised controlled trial of cognitive behaviour therapy (CBT) for people with co-occurring depression and alcohol use problems. To date, very few researchers have conducted research within this population, whose complex presentation makes it difficult for treatment providers to select and deliver effective treatment programs. Thus, although rates of depressive disorders and alcohol use problems are on the increase in our community, it is still not clear how best to manage and treat this group of people. Typically, people will often receive treatment for one part of their presentation, for example their depression or alcohol use problem. However, it is uncommon for the two conditions to be treated in an integrated way. This is certainly true for psychological treatments. Research programs to date have explored effective treatments for depression and alcohol use in the absence of the co-occurring condition. Currently it is not known how well people with co-occurring alcohol use problems and depression respond to treatments with a singular focus. Furthermore, it is not known whether integrating both alcohol use and depressive treatment approaches provides any additional benefit. This study is therefore significant, as it is one of the first to explore effective treatment approaches among people with co-occurring depressive and alcohol use problems. Resolution of these issues will better inform the treatment choices of clinicians practicing in both mental health and alcohol-other drug settings. Importantly, this will potentially improve the match between treatment and people with depression and substance use problems, a clinically prevalent population encountered in community settings.Read moreRead less