An Investigation Of The Effects Of Higher Plasma Glucose In The Normal Range On Cerebral Health.
Funder
National Health and Medical Research Council
Funding Amount
$727,524.00
Summary
Until recently it has been assumed that variation in blood sugar levels within the normal range in non-diabetics is innocuous. Recent findings from our team suggest that high normal sugar levels present risks to brain and cognitive health. This project will investigate in detail the extent to which higher sugar levels in healthy individuals living in the community are associated with brain changes over time, and whether these changes are associated with cognitive decline in middle- and old-age.
Successful Ageing In Older Men – Thriving Not Just Surviving In The Health In Men Study
Funder
National Health and Medical Research Council
Funding Amount
$628,810.00
Summary
Despite “Ageing well, ageing productively” being listed as a research priority, we still do not know what factors increase the ability for people to live a healthy old age, particularly as they enter their older years. Studies suggest that factors in late life have quite different effects on both survival and the major causes of illness. This application will use a large group of older men who have already been followed for 15 years to determine what increases the chance of successful ageing.
The Role Of Central Haemodynamics In Type 2 Diabetes Mellitus-related Brain Disease
Funder
National Health and Medical Research Council
Funding Amount
$899,704.00
Summary
Type 2 Diabetes Mellitus is associated with stiffening of major blood vessels which may allow the transmission of harmful pressure to the small vessels of the brain. This may in turn be responsible for damage to brain cells and a greater risk of dementia. This study will use state-of-the art techniques to test this theory. If true, it may open opportunities to reduce the risk of brain disease in diabetes by using therapies to reduce arterial stiffening.
Relaxin Therapy Reverses Large Artery Remodelling And Stiffening In Aged And Hypertensive Models
Funder
National Health and Medical Research Council
Funding Amount
$444,973.00
Summary
Hypertension and/or ageing result in morphological changes in large arteries with increased stiffness, which impacts negatively to cardiac function and increases the risk of cardiovascular disease. Currently there is no drug that can specifically and rapidly reverse the changes in large arteries. We will study a peptide hormone relaxin as a promising candidate drug in this setting. Our recent study strongly indicate the effectiveness of relaxin in softening stiffened large arteries.
Most diseases are much more common in the elderly. The reasons are poorly understood. We have evidence that the most common eye diseases, cataract and presbyopia, are due to the fact that the large molecules that make up the lens do not turnover. In lenses of older people proteins, which make up the bulk of the transparent tissue, become degraded. It turns out that very long lived proteins are quite common in the body. This proposal seeks to determine what role degradation of these ancient prote ....Most diseases are much more common in the elderly. The reasons are poorly understood. We have evidence that the most common eye diseases, cataract and presbyopia, are due to the fact that the large molecules that make up the lens do not turnover. In lenses of older people proteins, which make up the bulk of the transparent tissue, become degraded. It turns out that very long lived proteins are quite common in the body. This proposal seeks to determine what role degradation of these ancient proteins has in other diseases of aging.Read moreRead less
The Role Of Metals In Healthy Brain Aging: Identification Of Novel Compounds To Prevent Age-related Cognitive Decline
Funder
National Health and Medical Research Council
Funding Amount
$789,733.00
Summary
This grant will explore the basic mechanisms that underlie normal learning and memory. Specifically, we are focussing on how the modulation of metal levels may occur with age, and how this may cause or at least contribute to age-related cognitive impairment. We are also examining a novel therapeutic compound for the treatment of cognitive dysfunction. This work will have implications for both normal and pathological ageing.
Regulating Microglia To Combat Hippocampal-dependent Cognitive Decline In Ageing
Funder
National Health and Medical Research Council
Funding Amount
$493,768.00
Summary
Age-related cognitive decline, a hallmark of dementia, coincides with reduced activity of neural precursor cells and reduced rate of neuron production in the hippocampus – a key brain structure for learning and memory. Importantly, we have demonstrated that exercise can activate neural precursor cells and boost the production of new neurons as well as improve learning and memory. This project will explore the cellular and molecular mechanisms behind these exercise-induced benefits on cognition.
MicroRNA serves as critical factors in diverse biological events. However, it remains poorly understood how microRNAs contribute to the regulation of lifespan and age-associated changes, such as alterations in metabolic activity and an increased incidence of disorders. We aim to understand how microRNAs regulate stress response pathways and caloric restriction-mediated lifespan extension using the nematode Caenorhabditis elegans, an excellent model organism for ageing biology.
Dissecting Associations Of Estradiol And Testosterone With Cardiovascular Outcomes.
Funder
National Health and Medical Research Council
Funding Amount
$435,082.00
Summary
Controversy persists over whether falling testosterone (T) levels in ageing men increase risk of cardiovascular disease (CVD). T is converted by the enzyme aromatase into estradiol (E2). We will assess whether men with abnormal E2 levels are at risk of CVD, more so than men with low T. We will assess whether differences in the aromatase gene which alter E2 levels also influence the risk of CVD. The results will clarify the importance of hormones to CVD and guide new approaches to its treatment.
Little evidence supports interventions to improve mobility outcomes in frail older adults hospitalised for movement rehabilitation. This large randomised controlled trial investigates whether increasing the amount of physical activity during inpatient rehabilitation improves mobility and is cost effective. Frail older Australians are very high users of health services. This study will provide evidence for intensive physical therapy that is easily delivered, with significant benefits to older adu ....Little evidence supports interventions to improve mobility outcomes in frail older adults hospitalised for movement rehabilitation. This large randomised controlled trial investigates whether increasing the amount of physical activity during inpatient rehabilitation improves mobility and is cost effective. Frail older Australians are very high users of health services. This study will provide evidence for intensive physical therapy that is easily delivered, with significant benefits to older adults and the aged care health system.Read moreRead less