Restoration Of Cognitive Deficits Induced By Diabetes Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$261,251.00
Summary
Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.
The Effect Of Selected Nutraceuticals On Brain Blood Vessels And Memory.
Funder
National Health and Medical Research Council
Funding Amount
$445,206.00
Summary
The human brain receives 1000L of blood per day, distributed through minute vessels called capillaries. The integrity and function of brain capillaries is compromised with aging and this may contribute to memory disturbances. Our laboratory has identified several naturally occurring compounds that prevent age-associated defects of brain capillaries. The primary aim of this project is to explore if these agents are beneficial for restoring brain capillary function and memory.