Antibiotic resistance is a looming public health crisis. New antibiotics with new mechanisms of action are desperately needed. The long-term goal of this research is to develop new drugs that disarm bacteria to overcome the problem of antibiotic resistance.
Preventing Mental Health Problems In Children: A Population-based Cluster Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$431,133.00
Summary
14% of Australian children develop mental health problems. As treatment is time and cost intensive, prevention is the ideal model. This can be targeted to ‘at risk’ children, but may stigmatise families and have poor uptake. This project aims to trial whether a population targeted approach embedded in universal prevention performs better than targeted prevention alone, with each approach compared to ‘usual care’. The local and state government partners will ensure sustainability, policy relevanc ....14% of Australian children develop mental health problems. As treatment is time and cost intensive, prevention is the ideal model. This can be targeted to ‘at risk’ children, but may stigmatise families and have poor uptake. This project aims to trial whether a population targeted approach embedded in universal prevention performs better than targeted prevention alone, with each approach compared to ‘usual care’. The local and state government partners will ensure sustainability, policy relevance and uptake if effectiveRead moreRead less
Improving School Transition By Improving Child Sleep: A Translational Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$745,827.00
Summary
A successful transition to school sets a child on a path for life. A poor transition can lead to early drop out, poor peer relationships and poor emotional skills. In 2008/09, we found that a brief sleep intervention for children improved key determinants of a successful transition including social-emotional functioning and parent mental health. We now plan to see if the same intervention, delivered by school nurses, can have a similar effect.
Discovery Early Career Researcher Award - Grant ID: DE140101014
Funder
Australian Research Council
Funding Amount
$349,785.00
Summary
Extending economic design to non-market settings: An experimental study of mechanism design with intention-based preferences. Mechanism design is the engineering side of economic theory, which starts with assumptions regarding human nature and builds economic systems to best maximise efficiency according to these assumptions. This project studies mechanism design in experimental settings where individuals exhibit a desire to be kind to those who have been kind to them and unkind to those who ha ....Extending economic design to non-market settings: An experimental study of mechanism design with intention-based preferences. Mechanism design is the engineering side of economic theory, which starts with assumptions regarding human nature and builds economic systems to best maximise efficiency according to these assumptions. This project studies mechanism design in experimental settings where individuals exhibit a desire to be kind to those who have been kind to them and unkind to those who have not. Such preferences are common in many non-market settings and can have dramatic effects on the efficiency of potential mechanisms. The ultimate goal of this project is to develop applied mechanisms that are robust to heterogeneity in such intention-based preferences and which can be used in bilateral exchange, contract design and many other non-market settings.Read moreRead less
Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.
EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
The Centre for Research Excellence in Nursing Interventions for Hospitalised Patients will provide evidence to improve the nursing care of a broad range of hospitalised patients who are at risk of complications related to compromised skin integrity and poor pain/anxiety management. Systematic reviews and clinical trials will provide the basis for developing clinical practice guidelines to assist nurses in providing high quality care to the 3.5 million Australians admitted to hospital each year.
Economic efficiency and the provision of incentives for information acquisition and disclosure: a mechanism design approach. By uncovering what determines information acquisition, highlighting what allows experts and insiders to manipulate market outcomes, and studying the efficiency gains obtainable with the use of a variety of incentives schemes, this research will provide valuable insights for public policy concerning information diffusion and market transparency.
Bulk Mg based hydrogen storage alloys with faster activation. Bulk Mg based hydrogen storage alloys with faster activation. This project aims to improve the performance and efficiency of manufacture of magnesium-based hydrogen storage alloys, making them more cost competitive and widely useable. A hydrogen economy will reduce greenhouse gas emissions and improve air quality in urban areas. The expected outcomes are an understanding of the mechanisms governing the activation process, a necessary ....Bulk Mg based hydrogen storage alloys with faster activation. Bulk Mg based hydrogen storage alloys with faster activation. This project aims to improve the performance and efficiency of manufacture of magnesium-based hydrogen storage alloys, making them more cost competitive and widely useable. A hydrogen economy will reduce greenhouse gas emissions and improve air quality in urban areas. The expected outcomes are an understanding of the mechanisms governing the activation process, a necessary step in manufacture, and techniques to exploit these mechanisms to minimise the activation time. This is expected to develop competitive, bulk magnesium-based hydrogen storage alloys for effective and safe hydrogen storage systems.Read moreRead less
Targeted Development Of AMPK Β2-isoform Allosteric Activators
Funder
National Health and Medical Research Council
Funding Amount
$898,147.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to dramatic increases in the incidence of diseases associated with metabolic dysregulation e.g. type 2 diabetes. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as a cellular fuel gauge. We have discovered a new drug that crucially activates the form of AMPK found in metabolically active organs. We aim to develop this drug to unlock new therapeutic opportunity.