Investigations Into The Aetiology Of Giant Cell Arteritis
Funder
National Health and Medical Research Council
Funding Amount
$165,067.00
Summary
Despite much research the precise pathoetiology of giant cell arteritis is poorly understood. Both environmental and genetic factors are thought to contribute to disease development. Though to date, no overriding mechanism for disease development has been identified. This research will apply modern molecular techniques to further explore the pathogenic processes in this devastating disease which in turn will hopefully provide insight into novel treatment modalities.
Immunisation Safety And Adverse Events: Improving Our Understanding Of Causes And Management
Funder
National Health and Medical Research Council
Funding Amount
$295,223.00
Summary
As the incidence of vaccine preventable diseases declines, adverse events following vaccination become increasingly important for both public and providers. This fellowship aims to improve our understanding of the risks of vaccination, potential causes, including genetic predisposition and long term clinical outcomes. A range of epidemiological, clinical and genetics studies will be performed. All these studies are targeted to understand who, what, how and why vaccine reactions occur and what ca ....As the incidence of vaccine preventable diseases declines, adverse events following vaccination become increasingly important for both public and providers. This fellowship aims to improve our understanding of the risks of vaccination, potential causes, including genetic predisposition and long term clinical outcomes. A range of epidemiological, clinical and genetics studies will be performed. All these studies are targeted to understand who, what, how and why vaccine reactions occur and what can be done to prevent or manage them better.Read moreRead less
Strabismus is the pathological misalignment of the eyes associated with loss of binocular vision and is one of the most common human ophthalmological disorders. Patients with comitant strabismus have full eye movements, whereas patients with incomitant strabismus have limited eye movements, which causes the angle of strabismus to vary with gaze direction. This project aims to define genetic contributors to comitant congenital strabismus.
Dopamine Neuron Ontogeny: Convergent Neurobiological Pathway For Risk Factors Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$337,214.00
Summary
Schizophrenia is associated with changes in dopamine (a signalling molecule in the brain). These changes are present prior to psychosis, suggesting they begin early in development. Our aims are to manipulate key factors in the development of brain dopamine systems to clarify their role in psychosis and schizophrenia. This work has the potential to identify early brain changes that lead to schizophrenia, which in turn may generate better diagnoses and outcomes for people with this disorder.