Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100139
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
A Hot Isostatic Press (HIP) for aerospace and biomedical component processing. This facility will provide a hot isostatic press of sufficiently large capacity to maximise production efficiencies in aerospace and biomedical applications through net shape manufacturing. The facility will be able to process small components or prototypes which will behave in a manner similar to larger scale components.
Fracture Mechanics of Functionally Graded Materials: Coupled Thermoelectromechanical Problems. The primary goal of this project is to develop mathematical and computational models and techniques that are capable of novel design of functionally graded materials and structures that can dramatically increase the performance and reliability of artificial structures and devices. The applications areas are broad: from lightweight thermal protective coatings used in high-temperature environments to bio ....Fracture Mechanics of Functionally Graded Materials: Coupled Thermoelectromechanical Problems. The primary goal of this project is to develop mathematical and computational models and techniques that are capable of novel design of functionally graded materials and structures that can dramatically increase the performance and reliability of artificial structures and devices. The applications areas are broad: from lightweight thermal protective coatings used in high-temperature environments to biological hard tissues like bones and teeth. Efficient numerical methods will be developed to overcome difficulties encountered in material properties and loading conditions. The project will provide useful guidelines to design new, intelligent, multi-phase material systems, including biomaterial systems for biomedical applications.Read moreRead less
Designs of Periodic Microstructure Materials with Prescribed Multiphysical Properties. The evolutionary structural optimization (ESO) is an Australian initiative, which has made a significant impact on modern structural optimization. In advanced materials areas, Australia has well-established infrastructure and world-class expertise. Exploitation of ESO to advanced materials design will be of "exclusive significance" to Australia. More importantly, the new material design technology will present ....Designs of Periodic Microstructure Materials with Prescribed Multiphysical Properties. The evolutionary structural optimization (ESO) is an Australian initiative, which has made a significant impact on modern structural optimization. In advanced materials areas, Australia has well-established infrastructure and world-class expertise. Exploitation of ESO to advanced materials design will be of "exclusive significance" to Australia. More importantly, the new material design technology will present to Australia an opportunity to lead in this rapidly-growing area, which will definitely underpin Australia's standing as a major contributor and developer in a global materials market. It is expected that fresh classes of futuristic materials can be developed in a cost-effective fashion and add great economic benefits to Australia.Read moreRead less
A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boo ....A skin-on-a-chip device for investigating wound healing. This project aims to research the mechanism of skin wound healing. It will design a skin-on-a-chip microfluidic device that mimics human skin in vitro. This device will reduce the need for animal studies and assess how active compounds heal wounds. This project will design smart polymers with superior properties for controlled delivery of multiple active compounds in this device and choose the most effective combination of compounds to boost skin healing rate. This knowledge may ultimately be used to develop wound dressings that maximise healing rate for various skin defects such as chronic wounds and decrease health care costs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100175
Funder
Australian Research Council
Funding Amount
$347,070.00
Summary
Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used ....Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used to produce structures wherein living cells are spatially organised in combination with appropriate biomaterials and bioactive components, such as drugs or growth factors, in order to influence subsequent biological behaviour.Read moreRead less
Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this res ....Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this research also has implications for enhancing the scope and profitability of the Australian biotechnology industry. The project will be a vehicle for research training in a broad range of interdisciplinary areas. Students involved in the work will be equipped with a versatile and valuable combination of skills.Read moreRead less
Feasibility of biological hydrogen production from biomass wastes using activate sludge microorganisms. This study will focus on biological hydrogen production from biomass wastes, not only because hydrogen is a clean and high efficient energy, but also because it can be a process for waste treatment. The research is aimed at examining the feasibility of biological hydrogen production from an organic waste stream by hydrogen producing bacteria isolated and enriched from pretreated digested activ ....Feasibility of biological hydrogen production from biomass wastes using activate sludge microorganisms. This study will focus on biological hydrogen production from biomass wastes, not only because hydrogen is a clean and high efficient energy, but also because it can be a process for waste treatment. The research is aimed at examining the feasibility of biological hydrogen production from an organic waste stream by hydrogen producing bacteria isolated and enriched from pretreated digested activated sludge. The overall goal is to get better understanding of the biochemical mechanisms, metabolic pathways effecting on the intermediate and end-products, leading to high hydrogen productivity and yield.Read moreRead less
Novel Antimicrobial Biomaterials. There is a clear need for new materials that repel bacteria. Infections associated with biomaterials incur a high cost in terms of human health and well being, but such infections also increase the burden on the health care system by extending hospital stays and significantly elevating costs. The cost of a catheter-related blood stream infection is around $50,000 for patients in intensive care units. If all medical devices are considered, the cost of related inf ....Novel Antimicrobial Biomaterials. There is a clear need for new materials that repel bacteria. Infections associated with biomaterials incur a high cost in terms of human health and well being, but such infections also increase the burden on the health care system by extending hospital stays and significantly elevating costs. The cost of a catheter-related blood stream infection is around $50,000 for patients in intensive care units. If all medical devices are considered, the cost of related infections is then approximately $20 billion. The technology proposed here has the potential to reduce biomaterial related infection rates, improve health care and reduce health care costs. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668532
Funder
Australian Research Council
Funding Amount
$680,000.00
Summary
A Focussed Ion Beam-Scanning Electron Microscope for Advanced Analytical and Nanotechnology Research in South East Queensland. The minerals industry underpins Australia's current economic prosperity. The aging of the population presents major economic challenges in the delivery of cost effective health services. New nanotechnology-enabled industries will contribute to future national economic and environmental well-being. The research enhanced by this facility impacts all these areas. It will i ....A Focussed Ion Beam-Scanning Electron Microscope for Advanced Analytical and Nanotechnology Research in South East Queensland. The minerals industry underpins Australia's current economic prosperity. The aging of the population presents major economic challenges in the delivery of cost effective health services. New nanotechnology-enabled industries will contribute to future national economic and environmental well-being. The research enhanced by this facility impacts all these areas. It will improve mineral extraction and processing, enhance fundamental understanding of cellular interactions with textured surfaces, and lead to improved implantable material designs and improved implantable device lifetimes (eg hip and knee replacements). Development of advanced nanotechnology applications in energy, optoelectronics and sensors will be also be extended.Read moreRead less
Development of Cathodic Arc Plasma Immersion Ion Implantation (PIII) for biomaterials applications. Medical prostheses have intricate geometries, consisting of shapes such as screws, holes, wedges, cones and textured surfaces. Plasma Immersion Ion Implantation using metal or carbon ions produced by a cathodic arc has been found to be an excellent process for producing surface modification with the properties required in medical applications, such as low stress and excellent adhesion of very thic ....Development of Cathodic Arc Plasma Immersion Ion Implantation (PIII) for biomaterials applications. Medical prostheses have intricate geometries, consisting of shapes such as screws, holes, wedges, cones and textured surfaces. Plasma Immersion Ion Implantation using metal or carbon ions produced by a cathodic arc has been found to be an excellent process for producing surface modification with the properties required in medical applications, such as low stress and excellent adhesion of very thick coatings. To date this process has only been applied to simple, flat substrates. Extending it to shapes of interest for biomaterials applications will require comprehensive understanding and control of the sheath dynamics, which our combined theoretical and experimental approach will provide.Read moreRead less