Pathophysiology And Alternative Preventative Strategy For Breast Cancer Chemotherapy-induced Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Combination cytotoxic chemotherapy is the current optimal approach for treating breast cancer in premenopausal women. However, long-term skeletal defects (osteoporosis and fractures) caused by the chemotherapy have become an increasingly serious problem due to its intensified use and improved patient survival rate. This project seeks to elucidate the mechanisms for chemotherapy-induced bone defects and to initiate development of a preventative treatment using natural bioactive micronutrients.
Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
Three-dimensional solar-energy-driven hydrogen generation from ammonia. This project aims to address the challenges of hydrogen generation, transportation and storage by conceptualising a novel three-dimensional, solar-driven system for ammonia splitting on ultralight catalyst materials. The project expects to generate new knowledge in the area of advanced materials enabled hydrogen technologies through interdisciplinary approaches involving materials science, novel catalysis, and nanotechnology ....Three-dimensional solar-energy-driven hydrogen generation from ammonia. This project aims to address the challenges of hydrogen generation, transportation and storage by conceptualising a novel three-dimensional, solar-driven system for ammonia splitting on ultralight catalyst materials. The project expects to generate new knowledge in the area of advanced materials enabled hydrogen technologies through interdisciplinary approaches involving materials science, novel catalysis, and nanotechnology. Expected outcomes include new catalyst materials, design strategies, and advanced ammonia splitting technologies. This should provide significant benefits, such as newly created knowledge, technological innovation, research training, contributing to hydrogen economy and net zero for a greener environment.Read moreRead less
New Methodology for the Stereoselective Construction of Oxygen Heterocycles and Rare Sugar Analogues. The overall goal of this research is to develop new synthetic methods, particularly ones that exhibit high levels of stereocontrol. Current research efforts are directed towards the stereoselective construction of oxygen heterocycles and rare sugar analogues both in their racemic and chiral forms utilising 1,2-dioxines containing tethered hydroxyl moieties as the key chemical precursors. It is e ....New Methodology for the Stereoselective Construction of Oxygen Heterocycles and Rare Sugar Analogues. The overall goal of this research is to develop new synthetic methods, particularly ones that exhibit high levels of stereocontrol. Current research efforts are directed towards the stereoselective construction of oxygen heterocycles and rare sugar analogues both in their racemic and chiral forms utilising 1,2-dioxines containing tethered hydroxyl moieties as the key chemical precursors. It is envisaged that these investigations will lead to the development of simple experimental protocols for the synthesis of new bioactive organics.Read moreRead less
A Novel Metabolic Role For UDP Glycosyltransferase 8 (UGT8)
Funder
National Health and Medical Research Council
Funding Amount
$419,144.00
Summary
The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.
Structure And Function Of Antimicrobial Therapies And Their Interaction With Upper Respiratory Biofilms
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Bacterial infections of the upper respiratory tract are a major public health problem affecting millions of Australians. Commonly prescribed antibiotics are often not able to eradicate all bacteria as the bacteria often reside in a protective, self-produced gel-like matrix known as biofilm. This Fellowship aims to unravel the interaction of modern anti-infective therapeutics with the biofilm for the development of the next generation of safe and efficacious anti-biofilm strategies.
Development of Dry Coated Pigment Particles: Durability and Dispersion. Tiwest is the only business in the world that mines, separates, refines and manufactures titanium dioxide products in one region. Tiwest has a major impact on the Western Australian economy with more than 700 full time and contract jobs, export earnings of $400M (in 2004) and regular incomes for an estimated 500 businesses. The current wet pigment particle coating process, to ensure ease of handling and longevity, is a major ....Development of Dry Coated Pigment Particles: Durability and Dispersion. Tiwest is the only business in the world that mines, separates, refines and manufactures titanium dioxide products in one region. Tiwest has a major impact on the Western Australian economy with more than 700 full time and contract jobs, export earnings of $400M (in 2004) and regular incomes for an estimated 500 businesses. The current wet pigment particle coating process, to ensure ease of handling and longevity, is a major cost. An optimised pigment dry-coating process would ensure Tiwest's competitiveness through reduced processing costs and improved performance. This development has the potential to increase Tiwest's profitability by 10%.Read moreRead less
Solar-Driven C-H Functionalization Reactions. This project aims to investigate the functionalization reaction of unreactive C-H bonds using light as the source of energy. Light is a transformative change to synthesis as thermal activation is exchanged to solar activation. The latter gives access to excited state chemistry and enables reaction steps that are thermally inaccessible. It is a key strategy to leverage synthesis to the demands of the 21st century and to minimise its ecologic footprint ....Solar-Driven C-H Functionalization Reactions. This project aims to investigate the functionalization reaction of unreactive C-H bonds using light as the source of energy. Light is a transformative change to synthesis as thermal activation is exchanged to solar activation. The latter gives access to excited state chemistry and enables reaction steps that are thermally inaccessible. It is a key strategy to leverage synthesis to the demands of the 21st century and to minimise its ecologic footprint. At the same time this strategy provides a lever to profoundly impact and drive new concepts in synthesis. Significant benefits are expected, such as increase in fundamental knowledge on photochemical processes, but also the access to new materials for applications as drugs or OLEDs.Read moreRead less