Evolution of the dermomyotome in vertebrates. The project seeks to understand how different muscle populations within the embryo form and have evolved within the vertebrate phylogeny. All amniote muscles, except that of the head, derive from a transient embryonic structure termed the dermomyotome. The formation of muscle from the dermomyotome of amniotes uses a highly conserved mechanism that is distinct from that deployed by bony fish and amphibians. How the dermomyotome evolved to generate th ....Evolution of the dermomyotome in vertebrates. The project seeks to understand how different muscle populations within the embryo form and have evolved within the vertebrate phylogeny. All amniote muscles, except that of the head, derive from a transient embryonic structure termed the dermomyotome. The formation of muscle from the dermomyotome of amniotes uses a highly conserved mechanism that is distinct from that deployed by bony fish and amphibians. How the dermomyotome evolved to generate the distinct types of locomotor systems we see deployed throughout the vertebrate phylogeny remains unresolved. This project aims to contribute to an understanding of how different locomotor strategies deployed at important evolutionary transitions were generated.Read moreRead less
How limbs evolved from fins: the role of somite cells. This project aims to investigate the developmental basis of vertebrate appendage diversity and how during evolution limbs became fins. The project expects to determine how specific populations of cells that regulate fin formation arise during development, the genetic basis of their function, and how their role in development has evolved in lineages with divergent appendage anatomy. Expected outcomes include understanding the molecular basis ....How limbs evolved from fins: the role of somite cells. This project aims to investigate the developmental basis of vertebrate appendage diversity and how during evolution limbs became fins. The project expects to determine how specific populations of cells that regulate fin formation arise during development, the genetic basis of their function, and how their role in development has evolved in lineages with divergent appendage anatomy. Expected outcomes include understanding the molecular basis of the fin-limb transition and the origin of divergent appendage patterning systems. This should provide significant benefits by advancing our knowledge of the relationship between evolution and development, and understanding limb defects, which are amongst the most common of human congenital malformations.Read moreRead less
Fins to Limbs: Investigating the Evolution of complex Limb Musculature. This application aims to investigates the basis of the fin-to-limb transition, an event that set the stage for the entire tetrapod radiation. This project expects to generate new knowledge concerning the natural history of vertebrates using a multidisciplinary approach that combines paleontology and embryology of unique Australian fauna. While the skeletal changes associated with the move from water to land have been investi ....Fins to Limbs: Investigating the Evolution of complex Limb Musculature. This application aims to investigates the basis of the fin-to-limb transition, an event that set the stage for the entire tetrapod radiation. This project expects to generate new knowledge concerning the natural history of vertebrates using a multidisciplinary approach that combines paleontology and embryology of unique Australian fauna. While the skeletal changes associated with the move from water to land have been investigated, little is known about the origin of tetrapod limb muscles. This proposal has as an expected outcome, a determination of how limb muscles arose during evolution. This knowledge should provide significant benefits by transforming our understanding of the origins of the tetrapod body plan and our own natural history.Read moreRead less
A new universal mechanism controlling body proportions in animals. This project aims to establish that a recently-discovered mechanism, the inhibitory cascade, determines the basic proportions of appendages and body segments in a diverse range of animal groups, particularly vertebrates and arthropods. The goals of the project are to reveal the molecular mechanisms in mice and insects, and build computer simulations to show how to manipulate the control of development by the inhibitory cascade. T ....A new universal mechanism controlling body proportions in animals. This project aims to establish that a recently-discovered mechanism, the inhibitory cascade, determines the basic proportions of appendages and body segments in a diverse range of animal groups, particularly vertebrates and arthropods. The goals of the project are to reveal the molecular mechanisms in mice and insects, and build computer simulations to show how to manipulate the control of development by the inhibitory cascade. The project should benefit bioengineering by establishing control mechanisms for the manipulation and regeneration of teeth and limbs.Read moreRead less
Multiple stressors and vulnerability to global change. This project aims to develop a framework for accurately predicting species responses to environmental change. Future environments will involve shifts in many environmental factors, and species will evolve. Yet we lack understanding of how multiple environmental factors affect the ability of species to evolve and adapt to environmental change. The intended outcome is a tool for predicting the impact of environmental change on the distribution ....Multiple stressors and vulnerability to global change. This project aims to develop a framework for accurately predicting species responses to environmental change. Future environments will involve shifts in many environmental factors, and species will evolve. Yet we lack understanding of how multiple environmental factors affect the ability of species to evolve and adapt to environmental change. The intended outcome is a tool for predicting the impact of environmental change on the distribution and abundance of organisms. The benefits include improved conservation outcomes and better pest/disease vector control.Read moreRead less
Frayed at the edges? Integrating evolutionary genetics into the study of species distributional limits. Restricted species, like those in rainforests, represent the vast majority of biodiversity, but they face high risks of extinction due to climate change unless they can adapt. Using butterflies as a model, this project will examine whether rainforest restricted species are able to adapt to future climate change and provide insight into their extinction risk.
Are the sexes really equal? Sex-specific adaptation to environmental change. This project aims to develop a framework for accurately predicting species responses to global change. Many environmental factors will change, and species will evolve, but in a sex-specific manner. Yet understanding of how the sexes vary in their ability to evolve and adapt to such complex environmental change is lacking. This project aims to integrate environmental data with the sex-specific evolutionary potential of o ....Are the sexes really equal? Sex-specific adaptation to environmental change. This project aims to develop a framework for accurately predicting species responses to global change. Many environmental factors will change, and species will evolve, but in a sex-specific manner. Yet understanding of how the sexes vary in their ability to evolve and adapt to such complex environmental change is lacking. This project aims to integrate environmental data with the sex-specific evolutionary potential of organisms in response to multiple stressors in a spatially explicit context. The intended outcome is a powerful and general tool for predicting the impact of environmental change on the distribution and abundance of organisms. The benefits include improved conservation outcomes and better pest/disease vector control.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100507
Funder
Australian Research Council
Funding Amount
$352,454.00
Summary
Is adaptation to climate change really constrained in niche specialists? Accurately predicting the vulnerability of species to climate change is of paramount importance for managing biodiversity for conservation, agricultural and human health-related purposes. Mounting evidence indicates that adaptive responses to climate changes may be highly constrained, particularly in the biodiverse tropics. However, this is based on studies that do not reflect projected climatic variations. This project aim ....Is adaptation to climate change really constrained in niche specialists? Accurately predicting the vulnerability of species to climate change is of paramount importance for managing biodiversity for conservation, agricultural and human health-related purposes. Mounting evidence indicates that adaptive responses to climate changes may be highly constrained, particularly in the biodiverse tropics. However, this is based on studies that do not reflect projected climatic variations. This project aims to provide the first assessment of the capacity to adapt to climate change in widespread and tropical species using ecologically realistic conditions that reflect projected changes. The data will be used to develop accurate models predicting species vulnerability and serve to better guide conservation strategies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100141
Funder
Australian Research Council
Funding Amount
$380,219.00
Summary
Buffering climate change - Predicting the evolution of phenotypic plasticity. Environmental change is one of the biggest threats to biodiversity and may ultimately drive many species to extinction. Limiting biodiversity losses will require an understanding of species climate change responses. Phenotypic plasticity will be central to these responses, yet assessments of risk ignore the potential for phenotypic plasticity to buffer species from negative effects of environmental change. This project ....Buffering climate change - Predicting the evolution of phenotypic plasticity. Environmental change is one of the biggest threats to biodiversity and may ultimately drive many species to extinction. Limiting biodiversity losses will require an understanding of species climate change responses. Phenotypic plasticity will be central to these responses, yet assessments of risk ignore the potential for phenotypic plasticity to buffer species from negative effects of environmental change. This project will investigate the extent to which phenotypic plasticity mediates responses across species and environments. The outcome will be a better understanding of species’ responses to climate change, more accurate risk predictions and more effective protection of vulnerable environments.Read moreRead less
Will life be tougher in the tropics? The evidence for latitudinal variation in vulnerability to climate change. There is an urgent need to accurately assess the vulnerability of species to climate change. Tropical species, which make up the vast majority of the world’s biodiversity, are predicted to be most at risk from climate change. These predictions of risk and vulnerability ignore the ameliorating factors of evolutionary adaptation and phenotypic plasticity, making them inherently uncertai ....Will life be tougher in the tropics? The evidence for latitudinal variation in vulnerability to climate change. There is an urgent need to accurately assess the vulnerability of species to climate change. Tropical species, which make up the vast majority of the world’s biodiversity, are predicted to be most at risk from climate change. These predictions of risk and vulnerability ignore the ameliorating factors of evolutionary adaptation and phenotypic plasticity, making them inherently uncertain. This project will address this uncertainty by assessing the importance of evolutionary adaptation and phenotypic plasticity for responses to climate change in tropical and temperature species. This will provide a spatially explicit framework for the accurate assessment of risk and vulnerability to climate change.Read moreRead less