A Clinical Trial To Determine The Optimal Timing Of Androgen Deprivation In Relapsed Or Non-curable Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$627,600.00
Summary
The aim of the study is to clarify when is the optimal time to start hormone treatment for men with certain stages of prostate cancer. It has long been known that testosterone removal impedes prostate cancer growth, although not permanently. The removal of testosterone, however, has side effects , including loss of libido, hot flushes, weight gain, and in the longer term osteoporosis, loss of muscle bulk and mental changes such as loss of memory. Any benefit to be gained for a patient must there ....The aim of the study is to clarify when is the optimal time to start hormone treatment for men with certain stages of prostate cancer. It has long been known that testosterone removal impedes prostate cancer growth, although not permanently. The removal of testosterone, however, has side effects , including loss of libido, hot flushes, weight gain, and in the longer term osteoporosis, loss of muscle bulk and mental changes such as loss of memory. Any benefit to be gained for a patient must therefore be weighed against these side effects. This is particularly relevant in situations in which cure is not possible, when the aim of treatment should be to manage symptoms (either by preventing or delaying them or treating them as they arise). There are two situations in which a man may be diagnosed as having active prostate cancer but be without symptoms requiring immediate treatment. The first is after the failure of curative treatment, shown by the presence of prostate specific antigen (PSA) in the blood, but without any other evidence of prostate cancer. The second is a man newly diagnosed with asymptomatic prostate cancer, but with other reasons (such as heart disease) which make an attempt at cure inappropriate. We do not know in either case whether or not men live longer if treatment is started immediately, or whether it is reasonable to wait until symptoms develop, thus potentially postponing the side effects of treatment. The trial will therefore include these two groups of men. Half the men will be randomised to receive immediate treatment, and half to treatment starting when symptoms develop, or when there is evidence of progressive disease. The main endpoint is overall survival, balanced against quality of life and side effects from the disease and treatment. The hypothesis is that early treatment will improve survival with acceptable effects on quality of life.Read moreRead less
Application of a Novel Reflux Classifier for Separating Nut Shell Fragments from Powdered Food Mixtures. An important operation in the food industry is the physical separation of valuable particles from a mixture containing waste materials, such as shell fragments. The purpose of this study is to investigate the application of a novel gas-solid fluidised bed system, utilising parallel inclined plates to radically amplify the differential segregation rates to produce separations based on particle ....Application of a Novel Reflux Classifier for Separating Nut Shell Fragments from Powdered Food Mixtures. An important operation in the food industry is the physical separation of valuable particles from a mixture containing waste materials, such as shell fragments. The purpose of this study is to investigate the application of a novel gas-solid fluidised bed system, utilising parallel inclined plates to radically amplify the differential segregation rates to produce separations based on particle size. Our aim is to develop a fundamental understanding of the principles governing the nature of this system. The project should result in considerable technological and economic benefits for the food industry, a well trained and educated person at the postgraduate level, and a stronger collaborative link between the University and Sanitarium.Read moreRead less
Mullins-type effects in soft filled viscoelastic solids. Bread dough is made in vast quantities daily, and improvements in processing,especially sheet rolling,are needed,and to enable this we propose to create a novel mathematical description of the material. Also, wheat breeding cycles can be drastically shortened by using knowledge of dough rheology, since baking quality is closely linked to rheology. The mathematical framework can then be applied to other filled viscoelastic systems, and work ....Mullins-type effects in soft filled viscoelastic solids. Bread dough is made in vast quantities daily, and improvements in processing,especially sheet rolling,are needed,and to enable this we propose to create a novel mathematical description of the material. Also, wheat breeding cycles can be drastically shortened by using knowledge of dough rheology, since baking quality is closely linked to rheology. The mathematical framework can then be applied to other filled viscoelastic systems, and work on liquid crystals may be used to develop artificial muscle material, once their rheological description and behaviour are known.Read moreRead less
Ultra-lightweight alloys with unique multi-dimensional property profiles. Lightweight alloys with high specific-strength are an essential prerequisite in modern and future technologies. To be useful, they must also possess ductility and inherent corrosion resistance. The latter two properties, however, are inversely correlated with strength. This project proposes to break this paradox - not only in terms of a paradigm change regarding multi-property alloy design - but as applied to the most ligh ....Ultra-lightweight alloys with unique multi-dimensional property profiles. Lightweight alloys with high specific-strength are an essential prerequisite in modern and future technologies. To be useful, they must also possess ductility and inherent corrosion resistance. The latter two properties, however, are inversely correlated with strength. This project proposes to break this paradox - not only in terms of a paradigm change regarding multi-property alloy design - but as applied to the most lightweight engineering alloy system in existence, Magnesium-Lithium (Mg-Li), for which the impact on specific properties is immense. The aim is to develop ultra-lightweight Mg-Li based alloys with formidable property profiles via alloy design and thermomechanical processing. The expected outcome is a new class of structural corrosion resistant metal.Read moreRead less
Crystallography to deform and anneal metals. This project aims to study how the micromechanisms of plastic deformation affect the annealing behaviour of metals. This project will create a computational platform built on a reconstruction algorithm for three-dimensionally reconstructing experimentally-derived orientation data to generate the complete microstructure of crystalline material. It will reconstruct complex deformation and recrystallising structures in metals, through to the boundaries, ....Crystallography to deform and anneal metals. This project aims to study how the micromechanisms of plastic deformation affect the annealing behaviour of metals. This project will create a computational platform built on a reconstruction algorithm for three-dimensionally reconstructing experimentally-derived orientation data to generate the complete microstructure of crystalline material. It will reconstruct complex deformation and recrystallising structures in metals, through to the boundaries, phases and interfaces present in metals and ceramics. The intended outcome is the explanation of unresolved phenomena associated with thermomechanical processing of metals and alloys, useful for materials science, structural geology and condensed matter physics.Read moreRead less
Optimising Removal of Proteinaceous Foulants from Membranes. Removal of proteinacous foulants from membrane systems imposes both significant economic costs in terms of chemical usage as well as significant environmental costs in terms of water usage and production of effluents from the cleaning and rinsing waters. The outcome of this project should allow us to develop methods for the prediction and optimisation of membrane cleaning performance of relevance to major Australian industries includin ....Optimising Removal of Proteinaceous Foulants from Membranes. Removal of proteinacous foulants from membrane systems imposes both significant economic costs in terms of chemical usage as well as significant environmental costs in terms of water usage and production of effluents from the cleaning and rinsing waters. The outcome of this project should allow us to develop methods for the prediction and optimisation of membrane cleaning performance of relevance to major Australian industries including the dairy, food processing and water and waste water treatment industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346666
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Mobile high power diode laser for thermal processing applications. This proposal seeks to establish a mobile, high-power diode laser facility for thermal processing of in-situ components in the power generation, defence, shipbuilding and mining industries. Diode lasers offer significant advantages for laser thermal processing over conventional CO2 and Nd:YAG lasers in terms of their output wavelength, size and efficiency. The mobile high power diode laser facility will help build a strong infr ....Mobile high power diode laser for thermal processing applications. This proposal seeks to establish a mobile, high-power diode laser facility for thermal processing of in-situ components in the power generation, defence, shipbuilding and mining industries. Diode lasers offer significant advantages for laser thermal processing over conventional CO2 and Nd:YAG lasers in terms of their output wavelength, size and efficiency. The mobile high power diode laser facility will help build a strong infrastructure for in-situ repair of worn components and is expected to reduce overall component repair costs and time.Read moreRead less
Modelling soft filled viscoelastic solids. Wheat flour doughs are made in vast quantities daily, and improvements in processing, especially in sheeting (rolling) and extrusion are needed. To enable this we will create a novel mathematical description of the material which will be useful for predicting the shapes of processed products. Wheat breeding cycles can be shortened by using the model rheological parameters, since baking quality is closely linked to dough rheology. A number of Australian ....Modelling soft filled viscoelastic solids. Wheat flour doughs are made in vast quantities daily, and improvements in processing, especially in sheeting (rolling) and extrusion are needed. To enable this we will create a novel mathematical description of the material which will be useful for predicting the shapes of processed products. Wheat breeding cycles can be shortened by using the model rheological parameters, since baking quality is closely linked to dough rheology. A number of Australian wheats will be considered and their rheologies will be compared.Read moreRead less
Experimental and Numerical Investigation of Granular Flow in Hoppers. Handling and processing of bulk solids such as coal and metal ores perform a key function in many industries, and hoppers are the most common devices for storage and discharge of granular materials in this field. The proper design of this equipment is very important. This project provides a systematic investigation of granular flow in hoppers, which is essential in order to avoid structure failures and associated costs. It wil ....Experimental and Numerical Investigation of Granular Flow in Hoppers. Handling and processing of bulk solids such as coal and metal ores perform a key function in many industries, and hoppers are the most common devices for storage and discharge of granular materials in this field. The proper design of this equipment is very important. This project provides a systematic investigation of granular flow in hoppers, which is essential in order to avoid structure failures and associated costs. It will lead to a fundamental understanding of relevant industrial processes, improvement of their efficiency, and hence improved competitiveness of Australian mining/mineral/metallurgical industries.Read moreRead less
The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (th ....The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (the fibres from skins) to overcome this problem, and it will also be possible to dry sticky materials using material from the fruit itself, rather than additives such as maltodextrin.Read moreRead less