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Membrane-associated structure and the effect of metals on Abeta peptide from Alzheimer's disease. Alzheimer's disease currently affects 5% of Australians over 65, and will triple by year 2050 without an effective therapy. Much research to understand the causes of the disease has focused on the distinctive amyloid deposits found in patients' cerebral tissue. Recent evidence suggests that nerve cell death is actually directly caused by soluble forms of the protein fragments and metals that form th ....Membrane-associated structure and the effect of metals on Abeta peptide from Alzheimer's disease. Alzheimer's disease currently affects 5% of Australians over 65, and will triple by year 2050 without an effective therapy. Much research to understand the causes of the disease has focused on the distinctive amyloid deposits found in patients' cerebral tissue. Recent evidence suggests that nerve cell death is actually directly caused by soluble forms of the protein fragments and metals that form these deposits. We will investigate the specific molecular structure of these fragments with metals in relation to vesicles which mimic the nerve cell surface. This information may facilitate future biomedical efforts work to develop therapies, as well as develop general techniques to study similar structural problems.Read moreRead less
A wavelength-versatile visible laser for ophthalmic instrumentation. Treatment of a wide range of retinal disorders can be enhanced by a range of treatment modalities using laser beams of different colours. The outcome of this project will be a new laser technology for ophthalmic applications which is unique in its versatility while reducing size and cost. This will allow our partner, Opto Global, to gain a unique market position for its ophthalmic products with flow-on benefits to the Austral ....A wavelength-versatile visible laser for ophthalmic instrumentation. Treatment of a wide range of retinal disorders can be enhanced by a range of treatment modalities using laser beams of different colours. The outcome of this project will be a new laser technology for ophthalmic applications which is unique in its versatility while reducing size and cost. This will allow our partner, Opto Global, to gain a unique market position for its ophthalmic products with flow-on benefits to the Australian economy and ultimately benefits to the community through improved clinical efficacy and patient outcomes. The frontier technology represented by these new laser devices is also applicable to other industries including medical aesthetics, colour projection and display, and defence systems.Read moreRead less
Paper fluidics - A novel approach to low cost printable microsensors. Printing is perhaps the cheapest means of mass production available, yet it is used almost exclusively to mass produce only one thing, i.e. the printed word! This project will enable the development of disposable printed sensors for assessing the quality of water or the health of an individual. Sensors are generally relatively expensive, but the ability to print them on paper by the thousand will bring down the cost to a few ....Paper fluidics - A novel approach to low cost printable microsensors. Printing is perhaps the cheapest means of mass production available, yet it is used almost exclusively to mass produce only one thing, i.e. the printed word! This project will enable the development of disposable printed sensors for assessing the quality of water or the health of an individual. Sensors are generally relatively expensive, but the ability to print them on paper by the thousand will bring down the cost to a few cents. Such cheap, portable, easy-to-use sensors if widely available could profoundly affect the lives of people living in remote areas and developing countries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989726
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Nanophotonic and Microfluidic Integration Facility: a Platform for Optofluidics. Emerging 'lab on a chip' technology promises to provide low-cost, mass produced platforms for monitoring and processing of environmental and biological samples (eg. water quality and early cancer detection). These essentially fluidic platforms will require integrated photonic components to provide the vast array of optical interrogation options that are used in all modern laboratories. The proposed facility will e ....Nanophotonic and Microfluidic Integration Facility: a Platform for Optofluidics. Emerging 'lab on a chip' technology promises to provide low-cost, mass produced platforms for monitoring and processing of environmental and biological samples (eg. water quality and early cancer detection). These essentially fluidic platforms will require integrated photonic components to provide the vast array of optical interrogation options that are used in all modern laboratories. The proposed facility will enable Australian researchers to effectively integrate nano-photonic structures with engineered micro-fluidics into a single optofluidic chip. This will bring researchers in photonics and microfluidics together and will provide platforms supporting support biomedical and environmental and even fundamental physics projects.Read moreRead less
Development of high performance III-V semiconductor photoconductive antennas for terahertz applications. The practical applications of terahertz (THz) radiation include scientific probing for material characterisation, screening for weapons, explosives and biohazards, imaging for concealed objects and medical diagnostics, chemical and biological analysis, astronomy and space research. The success of this project will lead to the creation of a new generation of high performance THz emitters/detec ....Development of high performance III-V semiconductor photoconductive antennas for terahertz applications. The practical applications of terahertz (THz) radiation include scientific probing for material characterisation, screening for weapons, explosives and biohazards, imaging for concealed objects and medical diagnostics, chemical and biological analysis, astronomy and space research. The success of this project will lead to the creation of a new generation of high performance THz emitters/detectors essential for above applications, making great contribution to the Nation in the areas of science, technology, health, security and economy.Read moreRead less
Protein self-assembly on surfaces, interfaces and nanoparticles. Surfaces such as those presented by an air-liquid interface or air-borne nanoparticles exert significant effects on protein aggregation in biological environments. We will develop a comprehensive theoretical and experimental approach to study the effects of such surfaces on the self assembly of proteins leading to disease causing amyloid fibrils. This will provide a molecular level understanding of protein self-association and a ....Protein self-assembly on surfaces, interfaces and nanoparticles. Surfaces such as those presented by an air-liquid interface or air-borne nanoparticles exert significant effects on protein aggregation in biological environments. We will develop a comprehensive theoretical and experimental approach to study the effects of such surfaces on the self assembly of proteins leading to disease causing amyloid fibrils. This will provide a molecular level understanding of protein self-association and a rational basis for the design of inhibitors to stop protein aggregation. The work will also establish design principles for new nanomaterials via the controlled self assembly of proteins on surfaces.Read moreRead less
A biophotonics-based approach to the study of cell-mechanics. This study will help to promote and maintain good health. There is a connection between diseases such as arthritis and osteoporosis and cell mechanics. Our study will provide insight into cell mechanics, thereby helping to understand the pathophysiology of these diseases. The study is relevant to tissue engineering. There is ongoing research on mechanical conditioning of tissue substitutes. Understanding cell mechanics will help to op ....A biophotonics-based approach to the study of cell-mechanics. This study will help to promote and maintain good health. There is a connection between diseases such as arthritis and osteoporosis and cell mechanics. Our study will provide insight into cell mechanics, thereby helping to understand the pathophysiology of these diseases. The study is relevant to tissue engineering. There is ongoing research on mechanical conditioning of tissue substitutes. Understanding cell mechanics will help to optimise conditioning protocols, thereby improving the properties of engineered tissue.
During this study we will develop optical tools that have applications in the life sciences, in the development of advanced materials and in nanotechnology. Our project will promote Australian research in these fields.
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The astrophysical stochastic background of gravitational waves and detection by advanced high optical power interferometers: an Australia-US collaboration. The proposed project is designed to enable one of the most exciting and least studied components of the gravitational wave spectrum, the Astrophysical Gravitational wave Background (AGB), to be detected by Advanced LIGO. It will extend the Australia-US collaboration in Advanced LIGO to include modeling, simulation and detection methods of the ....The astrophysical stochastic background of gravitational waves and detection by advanced high optical power interferometers: an Australia-US collaboration. The proposed project is designed to enable one of the most exciting and least studied components of the gravitational wave spectrum, the Astrophysical Gravitational wave Background (AGB), to be detected by Advanced LIGO. It will extend the Australia-US collaboration in Advanced LIGO to include modeling, simulation and detection methods of the AGB and the study of the optical noise in LIGO and Advanced LIGO type systems. In particular we plan to search for anomalous noise sources and, especially those arising in high optical power cavities that could limit detection of the AGB.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0228799
Funder
Australian Research Council
Funding Amount
$1,602,000.00
Summary
Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to construct and operate two 8-metre optical/infrared telescopes, one in Chile, and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in way ....Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to construct and operate two 8-metre optical/infrared telescopes, one in Chile, and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not previously possible. Through membership of Gemini, Australian astronomers have access to the world-class facilities necessary to maintain their high international profile and great public visibility in Galactic and extragalactic astronomy, and also to enhance the national capacity to construct advanced scientific instrumentation. Australia has already won a contract to build one of the instruments.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453817
Funder
Australian Research Council
Funding Amount
$1,849,438.00
Summary
Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to build and operate two 8-metre optical/infrared telescopes, one in Chile and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not ....Australian Membership of the International Gemini Partnership. The International Gemini Partnership is an intergovernmental consortium formed to build and operate two 8-metre optical/infrared telescopes, one in Chile and the other in Hawaii. Australia joined the IGP in May 1998, taking approximately 5% of the partnership. The Gemini telescopes have been carefully engineered to exploit the superb atmospheric conditions at both sites, allowing users to address key astronomical problems in ways not previously possible. Through membership of Gemini, Australian astronomers have access to the world-class facilities necessary to maintain their high international profile and the great public visibility in Galactic and extragalactic astronomy, and also to enhance the national capacity to
construct advanced scientific instrumentation. Australia is currently building one of the instruments.
Note: in A7.1 GAMS incorrectly forces integer days/month. In full operation Australian astronomers will receive approximately 25 nights per year.Read moreRead less