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Scheme : NHMRC Project Grants
Research Topic : Adolescent Development
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  • Funded Activity

    Socioeconomic Variation In Community Risk Profiles Associated With Health And Behaviour Problems In Adolescents

    Funder
    National Health and Medical Research Council
    Funding Amount
    $459,700.00
    Summary
    Until recently, emotional and behavioural problems of adolescence have tended to be dismissed as part of the normal turbulence of adolescent development; however, attitudes to adolescent health and health promotion have changed quickly. Downward age-trends in tobacco, alcohol and illicit drug use have made adolescents a major target for health promotion. The practical potential for adolescent mental health promotion has gained considerable ground and knowledge of the modifiable determinants of y .... Until recently, emotional and behavioural problems of adolescence have tended to be dismissed as part of the normal turbulence of adolescent development; however, attitudes to adolescent health and health promotion have changed quickly. Downward age-trends in tobacco, alcohol and illicit drug use have made adolescents a major target for health promotion. The practical potential for adolescent mental health promotion has gained considerable ground and knowledge of the modifiable determinants of youth mental health problems has been progressed by a growing number of studies examining distal and proximal predictors in community samples. The project plans to comprehensively assess locally elevated risk factors and depressed protective factors predictive of a range of adolescent health and behaviour problems including substance abuse, obesity and depression in 30 communities across three Australian States. These communities will be selected from the entire socioeconomic spectrum to determine how the social context of our neighbourhoods may influence the health and behaviour of adolescents . Surveys of students in grade 6 and year 8 will be conducted. Each participating student will be weighed and measured and asked to complete a questionnaire that assesses a comprehensive range of community risk and protective factors.
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    Funded Activity

    Longitudinal Study Of Modifiable Influences For The Development Of Harmful Young Adult Alcohol Use And Related-problems.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,484,496.00
    Summary
    Young adulthood is a time of high vulnerability for alcohol use problems that are the major preventable contributor to death and injury in this age period. This 5-year project will identify modifiable influences in adolescence and young adulthood that contribute to harmful alcohol use. A cohort of almost 3,000 young people initially recruited in Victoria in 2002 (aged 11 to 15) will be followed for two further waves of data collection in 2010-11 (age 19 to 23) and 2012-13 (age 21 to 25).
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    Funded Activity

    Behavioural And Neuropsychiatric Aspects Of Transition To Severe Conduct Disorder In Adolescence.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $343,100.00
    Summary
    Conduct disorder represents an enormous cost to Australian society directly via the mental health and forensic systems, and indirect costs via its associations with other mental health problems, relationship problems, impaired social functioning, and substance use problems. Behavioural-family-based treatment have good success rates with young children with cooperative parents, however, there are a minority who progress to chronic problems despite this. Risk and resilience factors identifying chr .... Conduct disorder represents an enormous cost to Australian society directly via the mental health and forensic systems, and indirect costs via its associations with other mental health problems, relationship problems, impaired social functioning, and substance use problems. Behavioural-family-based treatment have good success rates with young children with cooperative parents, however, there are a minority who progress to chronic problems despite this. Risk and resilience factors identifying chronic patterns in early childhood are the key to early intervention. In previous research, this research team showed for the first time that callous-unemotional traits, a feature of chronic psychopathy, could be measured in children as young as 4 years, and was predictive of a range of negative outcomes. However, it was also found that the key neuropsychiatric markers characteristic of psychopathy, including reward dominance-punishment insensitivity and deficits in affective empathy, did not exist in conduct problem children prior to adolescence. Around the time of puberty, it appears that important changes occur in cognitive-affective processing styles that are associated with the adult form of psychopathy and antisocial behaviour. Thus, this research raises critical questions about the development of severe antisocial behaviour (or psychopathy) through the childhood to adolescent years. Our evidence indicates that early adolecence may be the period when intrapsychological characteristics representing chronic risk become concrete. The current research will be the first to map the development common neuropsychiatric markers (affective empathy, punishment insensitivity) of severe antisocial processes through the late childhood-adolescent period. The findings will have clear implications for models of antisocial behaviour and clinical approaches to working with conduct problem children and adolescents.
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    Funded Activity

    Adolescent And Young Adult Parental Antecedent Of Health And Development In The First Year Of Life

    Funder
    National Health and Medical Research Council
    Funding Amount
    $566,331.00
    Summary
    In the past 50 years the gap between reproductive maturity at puberty and first childbirth has extended to around 2 decades. This coincides with a rise in mental disorders and substance use that has the potential to affect the health of babies and their mothers. This study will build on 20 years of work to test in a 1000 offspring the extent to which problems such as prematurity, post-natal depression and early mother-child relationships may be affected by earlier mental health and behaviour.
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    Adolescent Alcohol And Tobacco Use/abuse: The Efficacy Of A Brief Motivational Interviewing And Skills Training Program

    Funder
    National Health and Medical Research Council
    Funding Amount
    $153,610.00
    Summary
    Alcohol abuse (regular and episodic heavy drinking) and tobacco use are common and increasing amongst young Australians. Around 49% of adolescents are regular drinkers, and 15.5% of females and 33% of males are occasional binge drinkers. Between 17.5% and 35.5% of adolescents smoke and this has increased from 1987. While the majority of young Australians moderate their drinking and smoking over time, about 5% will become heavy drinkers and 20% will become regular smokers. The public health conse .... Alcohol abuse (regular and episodic heavy drinking) and tobacco use are common and increasing amongst young Australians. Around 49% of adolescents are regular drinkers, and 15.5% of females and 33% of males are occasional binge drinkers. Between 17.5% and 35.5% of adolescents smoke and this has increased from 1987. While the majority of young Australians moderate their drinking and smoking over time, about 5% will become heavy drinkers and 20% will become regular smokers. The public health consequences of heavy drinking and smoking are now well documented. There are many studies exploring the effectiveness of universal prevention programs designed to reduce the chance of alcohol and tobacco problems in high school students. These are associated with short term reductions in the chance of smoking and heavy drinking, however it is unclear whether these programs work for adolescents who are at high risk of alcohol problems and sustained smoking. We know a lot about the sorts of risk factors associated with these problems. They include early onset of use, parental involvement and use, particular personality traits, poor marks, peer use, and poor social skills. There is no research that clearly evaluates prevention programs for adolescents who show these risk factors. In this research, a program tailored for high-risk adolescents will be compared to an educational program similar to what is often received in Australian high schools. It is expected that high-risk students will not show changes in the educational program, but will show long-term improvements after completing the enhanced program. If these results hold, the research will have very important implications for detecting high-risk students and modifying the ways in which these adolescents are treated so that we minimise the chance of further development of alcohol and tobacco problems. This could result in large health cost savings in the future.
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    Early Life Stress, Adolescent Brain Development And Risk For Adverse Cognitive And Psychosocial Outcomes

    Funder
    National Health and Medical Research Council
    Funding Amount
    $640,595.00
    Summary
    This project aims to study pre and postnatal childhood factors and examine their association with HPA-functioning, cognition, and mental health during adolescence in the Western Australian Pregnancy Cohort Study (Raine Study). Childhood exposures include not only trajectories of stressful life events, family functioning and mental health status during childhood, but also effects of intrauterine and postnatal growth patterns, and a comprehensive range of psychosocial, familial and environmental f .... This project aims to study pre and postnatal childhood factors and examine their association with HPA-functioning, cognition, and mental health during adolescence in the Western Australian Pregnancy Cohort Study (Raine Study). Childhood exposures include not only trajectories of stressful life events, family functioning and mental health status during childhood, but also effects of intrauterine and postnatal growth patterns, and a comprehensive range of psychosocial, familial and environmental factors. It is our objective to characterise functional polymorphisms for genes related to stress regulation and examine their interactions with early life exposures and their neurobiological consequences. We will also test 16 year old Raine subjects for cognitive ability, and in some we will image their brain activity while performing these tests. We anticipate to enhance the already comprehensive phenotypic Raine Study data base with neurobiological information for future neuroscience studies as the Raine cohort matures. We hypothesise that increased and sustained trajectories of early life stress, family dysfunction or poor mental health during childhood will increase the risk of Raine Study adolescents experiencing: (i) - increased stress sensitivity with higher baseline cortisol levels during adolescence; (ii) - increased adolescent stress sensitivity, if they are carriers of specific haplotypes of the glucocorticoid and mineralocorticoid receptor genes.;(iii) - depression during adolescence, if they are homozygous or heterozygous for the short allele of the serotonin transporter (5-HTT) gene; (iv) - poorer cognitive performance and increased atypical non-prefrontal cortex (PFC) brain activity during cognitive testing as measured by fMRI; and (v) -more mental health problems during adolescence.
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    Funded Activity

    Adolescent Depression: Evaluation Of A Preventive Intervention And Identification Of Risk Factors

    Funder
    National Health and Medical Research Council
    Funding Amount
    $307,313.00
    Summary
    This project will evaluate the long-term effectiveness of a school-based program to prevent depression among adolescents. It also aims to identify factors that predict the onset of depression in those who do not receive the intervention. The intervention focuses on the training of interpersonal problem solving skills and enhancement of optimistic thinking styles within a classroom-based curriculum. This project extends the current research program of the applicant. The intervention has already b .... This project will evaluate the long-term effectiveness of a school-based program to prevent depression among adolescents. It also aims to identify factors that predict the onset of depression in those who do not receive the intervention. The intervention focuses on the training of interpersonal problem solving skills and enhancement of optimistic thinking styles within a classroom-based curriculum. This project extends the current research program of the applicant. The intervention has already been developed and implemented with 1600 young people, with the support of local education authorities. The evaluation uses well-researched measures and includes a control group of adolescents who do not receive the intervention. Around 5% of adolescents experience clinical levels of depression and an even larger percentage show subclinical levels. Depression results in many debilitating consequences such as impaired school, work and social functioning and is also a risk factor in adolescent suicide. The prevention of mental health problems is a priority for Commonwealth and State governments and yet there is minimal research to demonstrate the effectiveness of preventive interventions, particularly in the area of depression. If the present study demonstrates a positive outcome, it will provide important guidelines as to preventive materials that should be included in the school curriculum. It is predicted that: a) the intervention will be associated with lower levels of depression over the 4 year follow-up, particularly for adolescents who are assessed as showing mild symptoms of depression, poor problem solving skills or pessimistic cognitive style prior to intervention b) risk factors for the development of depression in adolescents who do not receive the intervention will include initial mild symptoms of depression, poor problem solving skills and pessimistic attributional style.
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    Modifiable Influences On Tobacco, Cannabis And Other Drug Use In Early Adolescence.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $198,434.00
    Summary
    High rates of tobacco and cannabis use by Australia s young people are a continuing concern. This study will explore the factors that influence the development of drug use from late childhood. The International Youth Development Study collected data from 5,769 students in Grades 5, 7, and 9 in Washington State, U.S., and Victoria, Australia. Findings will both increase understanding of adolescent tobacco and cannabis use in the Australian context and inform prevention policy.
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    Funded Activity

    Identifying Endophenotypes For Eating Disorders And Their Relationship To Specific Genotypes And Environments

    Funder
    National Health and Medical Research Council
    Funding Amount
    $507,419.00
    Summary
    Around 15% of Australian women will have an eating disorder at some time in their life, and half of these will experience significant levels of depression and suicidality. The current project seeks to build better models of the initiation and maintenance of eating disorders that can inform development of effective treatments, with identification of genes and environments that predict the various components that define eating disorders (i.e., behaviours, temperaments and cognitive flexibility).
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    Funded Activity

    Prospective Study Of The Influence Of Social Networks & School Environments On Emotional Well-being Of Young Adults

    Funder
    National Health and Medical Research Council
    Funding Amount
    $202,200.00
    Summary
    It has become clearer in recent years that the role of the social environment may be as important as individual or interpersonal factors in understanding the risk and protective factors associated with disease prevention. Adolescence is the time when many preventable causes of premature morbidity and mortality arise. It is likely that the social environments encountered during early adolescence will have an impact on the development of emotional and physical well being in early adulthood. This s .... It has become clearer in recent years that the role of the social environment may be as important as individual or interpersonal factors in understanding the risk and protective factors associated with disease prevention. Adolescence is the time when many preventable causes of premature morbidity and mortality arise. It is likely that the social environments encountered during early adolescence will have an impact on the development of emotional and physical well being in early adulthood. This study will prospectively research the impact of school environment and quality of social networks in early adolescence on the emotional well being and health risk behaviours of young adults through the continued surveillance of a cohort of 2,782 students participating in the Gatehouse Project. This cohort has been surveyed four times; twice in Year 8 1997; once in Year 9 1998 and Year 10 1999. In 2002 the cohort will be on average 18 years old and will be first year post-secondary school. The major aim of the study is to investigate the prospective relationships between school environment in early adolescence and the mental and behavioural outcomes for young people in young adulthood. The continued surveillance of this cohort will allow us to assess the long term effects of school environments and adequacy of social networks at early adolescence on the emotional well being and social connectedness of older adolescents. This will contribute to our understanding of risk and protective factors in school-social environments that impact the health and well being of young adults. It will also inform further preventive intervention work that needs to take place in schools and communities to improve health outcomes for young adults.
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