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Birth Weight, Adult Weight And Podocyte Depletion.
Funder
National Health and Medical Research Council
Funding Amount
$796,252.00
Summary
A major role of our kidneys is to filter our blood. A key cell type in our kidney filters is an octopus-shaped cell known as the podocyte. If we are not born with enough podocytes, or if the filters grow too large after birth due for example to excessive weight gain, the podocytes cannot adequately filter the blood, and this can lead to kidney disease. We will measure podocyte endowment at birth, and assess the effects of weight gain and loss after birth on podocyte features and kidney health.
Targeting RCAN1 To Treat Type 2 Diabetes And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$814,468.00
Summary
Obesity and impaired insulin secretion are significant contributors to Type 2 diabetes. In this project we demonstrate that a protein called RCAN1 contributes to both fat mass and insulin secretion and that this contribution is exacerbated in obesity and in Type 2 diabetes. We will identify how RCAN1 controls these major metabolic pathways with outcomes including the development of new therapeutics for obesity and Type 2 diabetes.
Testing The Behavioural And Psychosocial Mechanisms Underlying Geographic Variation In Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$415,457.00
Summary
This study seeks to assess the mechanisms that explain the link between residential area features and the metabolic syndrome (obesity and high blood pressure, lipids and glucose), related to cardiometabolic diseases. There is more metabolic syndrome in disadvantaged areas but the reasons for this have not been empirically established. We will evaluate behavioural and psychosocialmechanisms that might independently and jointly explain the association between place and metabolic syndrome.
Examining The Impact Of Language Reclamation On Social And Emotional Well Being Among The Barngarla
Funder
National Health and Medical Research Council
Funding Amount
$1,111,633.00
Summary
Indigenous Australians are at high risk of experiencing mental illness. For many, it is the loss of land, culture, and identity that are causes of ill health. The Barngarla people of South Australia seek to reclaim their language due to its potential reinvigorating cultural identity and wellbeing. This offers a unique opportunity to document the links between language reclamation and wellness in Aboriginal people for the first time.
Pregnancy And Neonatal Diabetes Outcomes In Remote Australia (PANDORA) Cohort
Funder
National Health and Medical Research Council
Funding Amount
$2,395,410.00
Summary
The PANDORA study is a longitudinal birth cohort study recruited from a clinical register of Northern Territory women with diabetes in pregnancy (DIP). We will also recruit a comparator group of mothers without DIP and babies. Follow-up of mothers and infants to 3 years post-delivery will be from medical records, questionnaires and clinical assessment. Rates of progression to type 2 diabetes will be assessed among mothers, and growth, feeding patterns and diabetes risk markers among infants.