The brain plays a major role in the overconsumption of high fat/high sugar foods and this contributes to obesity but it receives little attention when it comes to developing novel treatments. My lab showed that a FDA-approved smoking cessation medication, that is a nicotinic receptor modulator, decreased the overconsumption of sugar. This project aims are to identify which nicotinic receptors and brain circuits are involved in the overconsumption of sucrose to improve treatments for obesity.
Substance abuse is a significant social and economic burden upon Australian societies and on societies around the world. Treatment remains problematic due to the multi-layer nature of the disease, difficulties with treatment compliance and less than ideal treatment regimes. The present study aims to improve treatments for alcohol and drug abuse using pre-clinical models to identify and characterize a new brain system implicated in drug-seeking.
Anxiety and addiction are disorders with high co-morbidity that present a major worldwide public health concern. Treatment in both cases often involves an approach called extinction which helps to reduce the relapsing nature of these disorders. This grant is designed to examine the role of a specific protein in addiction and anxiety, by virtue of its involvement in the process of extinction.
Repurposing An Alzheimer’s Trial Drug To Block Relapse In Cocaine Addiction Models
Funder
National Health and Medical Research Council
Funding Amount
$1,050,601.00
Summary
Repeated exposure to drugs of abuse, such as cocaine, alters the reward circuitry of the brain. Enduring changes in the connections between neurons underlie addiction-related behavioural patterns, drug craving and the propensity for relapse after drug withdrawal. The pre-clinical research in this proposal aims to test whether blocking the function of a particular brain protein in mice can prevent relapse in two different paradigms that model cocaine addiction in humans.
A Novel Approach For The Treatment Of Obesity: Examining The Potential Of Addiction Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$765,935.00
Summary
Difficulty in managing food intake, especially highly palatable food, can result in obesity and the health liabilities associated with being overweight. In its extreme, the difficulty reducing food intake resembles an addictive disorder. We have compelling preliminary data which show deficits in the brain associated with addiction are also found in diet-induced obesity. Therefore strategies used to treat addiction can potentially be used to treat obesity.
Australian Longitudinal Study Of Heroin Dependence: A 11 Year Prospective Cohort Study Of Mortality, Abstinence, Criminality And Psychiatric Comorbidity Among Heroin Users
Funder
National Health and Medical Research Council
Funding Amount
$372,295.00
Summary
To conduct the longest and most comprehensive prospective follow-up of Australian heroin users. A 11 year follow-up presents the unique opportunity to examine: Mortality rates, remission rates, criminal histories and levels of psychopathology ; Predictive factors of long term remission, mortality, criminality and the health service utilisation associated with heroin use careers.
Prevention Of Adverse Child Behavioural Development Following Maternal Depression In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$761,937.00
Summary
There is good evidence that if a woman is depressed while pregnant, her child is substantially more likely to have later emotional or behavioural problems. We will evaluate whether child outcomes following maternal depression in pregnancy can be improved by antenatal depression treatment. Our objective is to protect fetal and child development from the adverse developmental outcomes associated with untreated depression.
Promoting Responsible Drinking Practices To Drinkers To Reduce The Risk Of Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$271,476.00
Summary
Australians are heavy drinkers by world standards, which places them at risk of a wide range of alcohol-related harms. Broad-based interventions are needed to address a heavy drinking culture that involves regular engagement in heavy episodic drinking. This study will use a multi-method approach to develop and test messages that can be used to encourage enactment of responsible drinking practices that can reduce total alcohol intake and discourage binge drinking consumption patterns.
Mobile Intervention For Drinking In Young People (MIDY): Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$403,378.00
Summary
Binge drinking is a significant health and social issue in Australia. In this innovative trial, we will communicate with young people via their mobile phones while they are on a night out. Young people will send hourly information about their drinking and will receive a relevant message in response, encouraging them to slow down or avoid harmful activities. The methods and the messages were developed in partnership with young people and have been tested in real drinking situations.
Early Development, MicroRNAs, Dendritogenesis And Cognition
Funder
National Health and Medical Research Council
Funding Amount
$313,557.00
Summary
Neurodevelopmental disorders are characterised by a marked disruption of learning and memory, which is reflected by structural changes in the brains of affected individuals. However, little is known about the underlying mechanisms of this pathology or whether it is directly related to cognitive deficits across the lifespan. How the brain is wired during early development and its relationship to learning and memory in adulthood will therefore be determined.