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Improving Outcomes Of Radiotherapy Treatments Through In-vivo Dosimetric Verification
Funder
National Health and Medical Research Council
Funding Amount
$379,855.00
Summary
Radiotherapy remains an important non-surgical treatment for over 50 % of cancer patients. This project aims to develop methods that will enable the optimisation of the patients' treatment as it progresses by non-invasively measuring the radiation dose delivered each day. This will increase the likelihood of curing the patient as well as reducing the side effects experienced due to the treatment. This will improve the patients' quality of life post-treatment.
MICROFABRICATED DEVICES: A SIGNIFICANT ADVANCE FOR THE DETECTION AND MOLECULAR ANALYSES OF CIRCULATING CANCER CELLS?
Funder
National Health and Medical Research Council
Funding Amount
$422,107.00
Summary
Using advanced microfabrication concepts, this project aims to develop a platform technology able to capture tumour cells circulating in the blood of cancer patients. Although present only in extremely small numbers, these cells provide invaluable insights into the pathophysiology of the disease and consequently provide vital diagnostic and prognostic information. Molecular analyses of these cancer cells could ultimately enable the design of improved and personalized cancer treatment.
Effects And Mechanisms Of Direct Cardiac Compression In Interruption Of Myocardial Remodelling In Chronic Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$392,250.00
Summary
Heart failure (HF) is a disease where the heart pumping function is insufficient to provide adequate blood supply to the rest of the body. It is a highly debilitating disease affecting nearly 10 million people worldwide and has a <50% one-year survival in severe cases. Despite significant advances in pharmacotherapy, heart transplant is the only alternative for severe HF but is restricted by lack of donor organs to only ~ 5% of those requiring it. Research has shown that progression of HF is ....Heart failure (HF) is a disease where the heart pumping function is insufficient to provide adequate blood supply to the rest of the body. It is a highly debilitating disease affecting nearly 10 million people worldwide and has a <50% one-year survival in severe cases. Despite significant advances in pharmacotherapy, heart transplant is the only alternative for severe HF but is restricted by lack of donor organs to only ~ 5% of those requiring it. Research has shown that progression of HF is related to many subsequent changes after an initial insult. In addition to pumping failure, HF is associated with deranged compensatory responses such as neurohumoral over-activation, heart chamber enlargement, loss of functional cells, increase of inflammatory mediators and changes in cardiac skeleton (extracellular matrix). The changes in the heart are collectively known as remodelling. Mechanical heart assist is now considered a potential destination therapy for severe HF, superior to pharmacotherapy alone. Improvement of cardiac pumping function and even successful weaning from devices has been reported, along with observations of reverse remodelling. The success of this approach has been limited however, particularly with HF due to coronary disease, the most prevalent form. We developed a novel HeartPatch mechanical assist device to compress the heart from its outer surface. It gives support to both main chambers and avoids blood contact, a feature of currently available devices associated with complications such as blood clotting and infection. Our device has proved effective in animals with acute HF and even with cardiac arrest. We propose to study the effects of our device on the process of remodelling in HF with coronary disease in a controlled manner. The project will enhance understanding of the mechanisms involved in reverse remodelling and further the development of a device which may potentially benefit many severe HF patients.Read moreRead less
Development And Evaluation Of Teleophthalmic Systems For Screening Of Common Blinding Eye Diseases
Funder
National Health and Medical Research Council
Funding Amount
$263,918.00
Summary
Portable ophthalmic instruments will provide digital images for storage and telemetric transmission to a disease control centre. We will be assessing and developing new portable ophthalmic imaging instruments, and validating them for common blinding eye conditions. The aim is to assess the ability of various health personal to document glaucoma, diabetic retinopathy, active trachoma, corneal scarring and cataract in rural screenings using digital imaging technology. A network of ophthalmologists ....Portable ophthalmic instruments will provide digital images for storage and telemetric transmission to a disease control centre. We will be assessing and developing new portable ophthalmic imaging instruments, and validating them for common blinding eye conditions. The aim is to assess the ability of various health personal to document glaucoma, diabetic retinopathy, active trachoma, corneal scarring and cataract in rural screenings using digital imaging technology. A network of ophthalmologists, health department personnel and aboriginal health workers in Western Australia will be involved. The project will also examine the quality of images obtained by health workers with various levels of skills and compare this with conventional photographs currently obtained by the screening network. Finally, the project will demonstrate practicality of the large scale storage of digital images of patient eyes. Preliminary evaluations have been performed on our teleophthalmology system using different portable instruments namely a handheld fundus camera, slit-lamp and indirect ophthalmoscope. We have also tested our teleophthalmology system at the Dr. Soetomo Hospital (Airlangga University) in Surabaya, Indonesia. Images captured using the handheld fundus camera were successfully transmitted to Lions Eye Institute through satellite, mobile and Internet lines. This pilot project has been sponsored by the Western Australian Department of Trade and Commerce and Telstra.Read moreRead less
Drinking Patterns, Gender And Social Roles In Alcohol Problems In Victoria, In An International Comparative Context
Funder
National Health and Medical Research Council
Funding Amount
$342,239.00
Summary
The varied impacts of drinking in the family and other gendered relations are an important and understudied aspect of alcohol studies, with general social and policy implications. The proposed research will make an important contribution to developing quantitative research in this area in Australia. The project uses concepts and measures which are novel in an Australian environment, and the international comparative aspect of the project, with comparable questionnaires in a wide diversity of soc ....The varied impacts of drinking in the family and other gendered relations are an important and understudied aspect of alcohol studies, with general social and policy implications. The proposed research will make an important contribution to developing quantitative research in this area in Australia. The project uses concepts and measures which are novel in an Australian environment, and the international comparative aspect of the project, with comparable questionnaires in a wide diversity of societies, is novel and innovative for the alcohol research field in general. Measures of social problems from drinking, and particularly and family and relationship, developed in analysing the study material will be made more broadly available for use in future studies, raising the possibility that the study may serve as a first measurement point for future data-series over time.Read moreRead less
Effects Of Lead And Socio-cultural Factors On Cognition And Behaviour Of Children In Port Pirie And Broken Hill
Funder
National Health and Medical Research Council
Funding Amount
$394,825.00
Summary
The effect of lead on children's 'intelligence' is controversial. Poorer IQ scores in children with higher exposure to lead, have been found reasonably consistently, - but there is disagreement on whether lead exposure is simply a common ASSOCIATE of poor IQ, or whether it actually CAUSES deficits. In 1994, the NHMRC prudently recommended a graded series of interventions to be implemented, depending on the proprtion of children in the community with blood lead concentrations in specific categori ....The effect of lead on children's 'intelligence' is controversial. Poorer IQ scores in children with higher exposure to lead, have been found reasonably consistently, - but there is disagreement on whether lead exposure is simply a common ASSOCIATE of poor IQ, or whether it actually CAUSES deficits. In 1994, the NHMRC prudently recommended a graded series of interventions to be implemented, depending on the proprtion of children in the community with blood lead concentrations in specific categories above 10 ug lead -100 ml of blood. The choice of this figure (10 ug-dl) was more pragmatic than scientific; there being very little data on the health effects of exposures below 10 ug-dl available at that time. A recent analysis of pooled data from past studies has now suggested there may be very large effects on child IQ at blood lead concentration BELOW 10 ug-dl. Health authorities will soon be lobbied intensely to spend vast sums on new lead abatement programs. Cities like Port Pirie and Broken Hill (where cooperative programs have achieved such significant reductions in lead exposure that a high percentage of their children now have blood lead levels below 10 ug-dl), will be forced to examine expensive options to avoid closure of the industries which provide their economic backbones, if this analysis proves to be correct. Our proposal argues that before committing to new and costly abatement programs, there is an urgent need to augment our evidence-base by conducting a new study ofchildren with lead exposures below 10 ug-dl, using more modern measures of intelligence. The study will pay closer attention to some of the socio-cultural and inherited determinants of child IQ which may have confounded the lead-IQ association in past studies, and will supplement IQ assessments (which are now considered to derive from a very old and narrow view of intelligence) with new tools for measuring 'intelligence' that may be less socio-culturally dependent.Read moreRead less
Living In A Rural Community: A Longitudinal Study Of The Course And Outcome Of Mental Health And Wellbeing.
Funder
National Health and Medical Research Council
Funding Amount
$841,947.00
Summary
This unique rural Australian study will investigate individual, family and community factors associated with the mental health and wellbeing of residents in rural communities of New South Wales. It aims to identify factors that may maintain or promote mental health, thereby investigating the potential protective effect of community factors, as well as more proximal social factors (such as family-household attributes and responses) on dimensions of mental health and wellbeing among rural people.