The Effect Of Follicular Helper T Cells (TFH) On AID Regulation And Selection Of High Affinity Germinal Centre B Cells.
Funder
National Health and Medical Research Council
Funding Amount
$430,964.00
Summary
An integral component of an immune response to foreign pathogens is the production of antibodies by B cells. However, if antibodies react to self-antigens (human molecules rather than bacteria or viruses) they may also cause autoimmune diseases such as lupus. This research project is investigating the mechanisms that control antibody generation by B cells, and how these are dysregulated in autoimmune diseases, such as lupus.