The Interaction Of LPS Pathway Genes With Pre-natal And Early Exposure To LPS And Allergens Predicts Atopy At Age One
Funder
National Health and Medical Research Council
Funding Amount
$381,263.00
Summary
The poor understanding of the cause of asthma has made prevention strategies unsuccessful. This study will provide valuable data for understanding the interactions between exposure to environmental stimuli and LPS pathway genes on the development of allergy and asthma in infants. As environmental modifications and dietary interventions during pregnancy are being investigated, the findings from the proposed study will be important in guiding prevention practices of allergic diseases.
Respiratory Viral Infections As Triggers Of Acute Severe Asthma Exacerbations In Atopics: Mechanistic Studies In An Experimental Model
Funder
National Health and Medical Research Council
Funding Amount
$659,494.00
Summary
An important unresolved issue in asthma research is why almost all the children who present in hospital emergency with very severe asthma attacks are both allergic and virally infected. This project will seek to define how immune responses to viruses and aeroallergens interact to create very severe inflammation in the airways thus precipitating the severest type of asthma attacks. Understanding the underlying mechanisms will hopefully provide new clues towards better treatments.
Waxing And Waning Of Asthma During Transition From The Teens To Adulthood: Identification Of Immunophenotypic Markers To Predict Disease Trajectory And Guide Development Of Treatment Strategies To Prevent Progression To Chronicity
Funder
National Health and Medical Research Council
Funding Amount
$736,166.00
Summary
The project will seek to identify biomarkers in teenage/young adult asthmatics that can distinguish between those who are "growing out" of the disease, versus those who are progressing towards chronic severe asthma. This knowledge will inform the development of more effective treatment programs for this age group.