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Haematopoiesis, Metabolic Disorders And Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Dr. Murphy’s work is centred on examining how different diseases such as obesity, diabetes and other inflammatory conditions increase people’s risk of heart disease. He will explore how these various inflammatory diseases influence the produce increased levels of white blood cells, which is important as increased white blood cells are positively associated with disease severity. He will also explore the relationship between blood cancers, know as leukaemia and how obesity.
Macrophage inhibitory cytokine-1 (MIC-1) participates in cancer, stroke and heart attack. Studies show that measurement of MIC-1 in blood and cancer tissue might be useful to detect the development of cancer and determine whether it will spread. Also, MIC-1 measurement can identify people who are at risk of dying of cancer, heart attack and stroke. This study will show how MIC-1 may be used to prevent, diagnose and help treat these conditions and reduce healthcare costs.
Development Of A Low-cost, Very Low-radiation Community-based Screening Method For Primary Prevention Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Virtually everyone's life has been affected by cardiovascular disease (CVD) in some way. There are no routine community-based tests to identify asymptomatic CVD due to current tests being invasive, expensive, time-consuming or high radiation exposure. A low cost, very low radiation test from existing machines used for osteoporosis screening can assess a measure of asymptomatic CVD. This fellowship seeks to develop this test for community-based screening strategies.
Targeting Inflammation-associated Macrophages For Imaging And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
Cancer and cardiovascular disease are the most common causes of morbidity and mortality worldwide. The development of effective therapies remains a major challenge and is often associated with severe side-effects. I recently developed novel targeting reagents to effectively deliver therapeutics and diagnostic agents deep inside diseased tissues, such as tumours and atherosclerotic plaques. My research will further explore their therapeutic and imaging applications in cancer and atherosclerosis.
Non-invasive Assessment Of Vascular Health In Maternal-fetal And Other Susceptible Populations
Funder
National Health and Medical Research Council
Funding Amount
$402,679.00
Summary
The research in this application focuses on the development and refinement of non-invasive techniques for assessing subclinical atherosclerosis, and cross-disciplinary application of these techniques to identify cardiovascular risk factors and ‘at-risk’ individuals. Emerging and poorly understood risk factors of public health importance are a priority, and include: * Maternal-fetal health * Obesity * Indigenous health