Preventing Diabetic Complications Using Anti-inflammatory Peptides
Funder
National Health and Medical Research Council
Funding Amount
$805,146.00
Summary
The Receptor for Advanced Glycation End-products (RAGE) triggers inflammation. It was thought that this receptor was only activated from outside the cell. However, we discovered that other receptors can activate it from the inside. This is called trans-activation. During this ideas grant, we will develop innovative ways to block trans-activation of RAGE and translate these findings to make new therapeutics that are highly-relevant to he development and progression of diabetes.
Serial Imaging Of Molecular And Microstructural Changes In Atherosclerosis: Tracking Plaques Towards Destabilisation
Funder
National Health and Medical Research Council
Funding Amount
$992,112.00
Summary
Most heart attacks are caused by high-risk plaques in coronary arteries. A significant unmet need in cardiology is to reliably detect high-risk plaques before they are life-threatening. This project will generate unique insights into plaque pathogenesis over time to see how plaques become high-risk and cause heart attacks. This project will also develop a clinically applicable tool to detect high-risk plaques, leading to significantly reduced complications and cost in heart disease.
Developing Smart Nanomedicine To Enable Advanced Diagnosis And Stimuli-responsive Treatment For Atherosclerosis And Thrombosis
Funder
National Health and Medical Research Council
Funding Amount
$523,342.00
Summary
The early detection and accurate characterization of life-threatening diseases such as cardiovascular diseases are critical to the design of treatment. A therapeutic approach that provides an efficient treatment with minimal side-effects is highly desired by both patients and healthcare systems. This project aims to develop smart nanomedicine with incorporated diagnostic sensor and external stimuli-responsive treatment mechanisms for cardiovascular diseases.
Defining A New Player In Atherosclerosis: The Role Of Adventitial Haemangioblasts As An Outside-in Driver Of Plaque Growth And Stability.
Funder
National Health and Medical Research Council
Funding Amount
$728,005.00
Summary
As the underlying cause of heart attack, atherosclerosis is a leading cause of death worldwide. New approaches to treatment are desperately needed and this requires a better understanding of how atherosclerotic plaques form in arteries. This project studies a new population of stem cells that we have discovered in the outer layer of arteries, to determine how they cause plaques to form, so that we can develop new therapies that target these stem cells to more effectively treat atherosclerosis.