A tight squeeze: engineering anti-fibrotic depot aerosols that circumvent the epithelia. A new molecule for the treatment of pulmonary lung fibrosis has been developed but there is no inhalation medicine capable of targeting the responsible cells. This project will develop an advanced inhalation technology capable of bypassing the lung surface so that we can target the fibrotic cells beneath.
Pandora's toolbox: The use of Fluorosomes to formulate nanoparticle gene therapy for respiratory diseases. This project will result in a technology for treating lung diseases. A new approach to gene therapy will be developed via packaging these bio-molecule inside a self-assembled Fluorosome structure for delivery using conventional pressurised inhalers. These systems will be investigated using state-of-the-art technologies developed during the project.
An attack from all angles! Multiphase particle systems that target respiratory infection. This project will result in advanced inhaled medicines for lung infection. Micron-particles will be engineered to have sustained drug release when deposited at sites of infection, yet avoid natural clearance and defence mechanisms. To study these systems, a series of characterisation, in vitro cell and in silico tools will be developed.
Multi-drug dry powder inhalation systems for the effective treatment of chronic obstructive pulmonary disease. Utilising a combination of particle engineering, computer modeling, rapid prototyping and high-speed 3D imaging this project will develop a novel approach to treat chronic obstructive pulmonary disease. A multi-drug particle system whose surface is independent of the drugs incorporated will be optimised in a novel high efficiency inhalation device.