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Improving Outcomes In Pregnancies Complicated By Asthma: Understanding Mechanisms And Defining Interventions
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
Asthma is a common disease to complicate pregnancy and it is important to identify ways of effectively managing the disease to ensure the fetus has the best possible outcome. The current research focusses on this disease and looks at ways of improving management in pregnancy and improving outcomes for the baby.
Early Life Exposures And Chronic Disease: Mechanisms And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$851,980.00
Summary
The world is facing an epidemic of chronic disease and adverse environmental exposures in early life are partly responsible. One reason why we have not been able to do more to prevent this is the lack of appropriate methods for measuring environmental exposures during pregnancy and infancy. My research will develop and validate methods for measuring exposures early life and the health consequences of these exposures with the aim of developing preventative interventions
Delivering On The GWAS Promise: From Genetic Discoveries To Novel Drug Targets For Asthma
Funder
National Health and Medical Research Council
Funding Amount
$697,605.00
Summary
The aim of this study is to identify new drug targets for asthma. This is important because for 6 in 10 asthma patients, current treatments do not adequately control disease symptoms and so these individuals are at a higher risk of having severe exacerbations. I propose that identifying asthma risk genes represents our best chance to identify novel drug targets for asthma. In this study, I will identify new asthma risk genes and test whether blocking these genes can alleviate disease symptoms.
Allergies and chronic respiratory diseases are major causes of illness and death in Australia. Worryingly there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will investigate these questions and provide evidence to guide health policy and clinical management. As this program is built on state-of the-art methods and technology, these original Australian findings will be of great importance internationally.
Epidemiological Investigation Of The Role Of Early Life Environment In The Development Of Immune Function And Allergic And Autoimmune Disease: Knowledge Generation For Future Primary Prevention.
Funder
National Health and Medical Research Council
Funding Amount
$664,584.00
Summary
Immune diseases, which include allergic and autoimmune diseases, are accounting for an increasing fraction of the disease burden in Australia. It is now increasingly recognised that early life changes to the immune system by environmental factors can impact on the risk of these diseases. The goal of this fellowship is the prevention of allergic and autoimmune disease.
Inflammatory Airway Diseases In Children: Mechanisms Underlying And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
Professor Sly’s research concentrates on understanding why some children develop chronic lung disease and on finding ways to prevent this from happening.
Development Of New Therapies For Respiratory Diseases And Infection
Funder
National Health and Medical Research Council
Funding Amount
$847,490.00
Summary
Prof Hansbro’s group have developed world 1st experimental models of emphysema, severe asthma infection and lung cancer. He uses them to further our understanding of these untreatable diseases. This has led to the development of new potential therapeutic approaches. Now, in discovery programs he will expand studies of pathogenesis to identify new therapeutic targets these diseases. In development and translational programs he will progress new therapies towards clinical application.
My research focuses on allergies and chronic respiratory disease in children, teenagers and adults. My goal is to identify the factors, which cause these conditions and also the factors, which can stop these conditions from getting worse. I will work with health professionals and the community to make sure the results of my research are used by doctors to improve the care of people with allergies and chronic respiratory diseases.
The Role Of Maternal Asthma In The Health Of Mother, Fetus And Child
Funder
National Health and Medical Research Council
Funding Amount
$621,458.00
Summary
A/Prof Clifton is a world leader in the area of maternal asthma and pregnancy. Her strengths relate to the fact that she can interface between basic science and the clinic in order to change clinical practice and policy. She consistently publishes her work and is regularly invited as a plenary speaker. She is a recognised leader in her field by her many prestigious appointments. She was awarded an outstanding mentor award 2011 in recognition of her contribution to student supervision and staff m ....A/Prof Clifton is a world leader in the area of maternal asthma and pregnancy. Her strengths relate to the fact that she can interface between basic science and the clinic in order to change clinical practice and policy. She consistently publishes her work and is regularly invited as a plenary speaker. She is a recognised leader in her field by her many prestigious appointments. She was awarded an outstanding mentor award 2011 in recognition of her contribution to student supervision and staff mentoring.Read moreRead less
Understanding The Impact Of Preterm Birth On Development: Improving Outcomes For Preterm Infants.
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
Approximately 10% of babies are born prematurely and many suffer long-term health problems. Our aim is to understand how premature birth affects the development of the cardiovascular, respiratory and central nervous systems. This understanding will help to improve the long-term health outcomes for premature infants. By working with medical practitioners treating premature babies we are well placed to translate our findings on preventing and treating developmental injury into clinical practice.