Adaptation of respiratory chemoreception: role of inhibitory neuropeptides. The project aims to investigate how the retrotrapezoid nucleus (RTN) is involved in respiratory adaptation to hypercapnia. Chemoreceptor neurons in the RTN are crucial for life however, the mechanisms that underlie their basal and stimulated activity, to control breathing, remain to be clarified. This project will investigate the role of galanin in RTN-mediated regulation of breathing. The project looks to determine inst ....Adaptation of respiratory chemoreception: role of inhibitory neuropeptides. The project aims to investigate how the retrotrapezoid nucleus (RTN) is involved in respiratory adaptation to hypercapnia. Chemoreceptor neurons in the RTN are crucial for life however, the mechanisms that underlie their basal and stimulated activity, to control breathing, remain to be clarified. This project will investigate the role of galanin in RTN-mediated regulation of breathing. The project looks to determine instructive and multifunctional roles of peptidergic chemosensory neurons and their contribution to local inhibitory control of the respiratory network. New knowledge from the project may in the future assist translational research into respiratory disorders and lead to technological advances.Read moreRead less
Engineering an environmentally-friendly metered dose inhaler. This project aims to deliver a novel simulation framework to accurately predict the behaviour of metered dose inhaler sprays using advanced numerical methods for flash-evaporating turbulent flows developed by the investigators. The project expects to generate new knowledge of the complex physics which occur in these devices through a first of its kind combination of unsteady non-equilibrium thermodynamics, turbulence and spray models. ....Engineering an environmentally-friendly metered dose inhaler. This project aims to deliver a novel simulation framework to accurately predict the behaviour of metered dose inhaler sprays using advanced numerical methods for flash-evaporating turbulent flows developed by the investigators. The project expects to generate new knowledge of the complex physics which occur in these devices through a first of its kind combination of unsteady non-equilibrium thermodynamics, turbulence and spray models. Expected outcomes of this project include a novel ability to predict and optimise the performance of inhalers to suit environmentally-friendly replacement propellants. This will significantly benefit the pharmaceutical sector as it will accelerate the design of next-generation inhalers and propellants.Read moreRead less
Engineering better sprays for leaf coating: from drop impact to retention. This proposal aims to understand the performance of a unique rheological modifier that can enable an order of magnitude increase in coating efficiency for aerosol sprays while not affecting the quality of droplet formation during spraying. The effect occurs via a dispersed network of fibrous particles in water, providing a weak but useful ability to coat surfaces by responsively adjusting its structure. The material is ex ....Engineering better sprays for leaf coating: from drop impact to retention. This proposal aims to understand the performance of a unique rheological modifier that can enable an order of magnitude increase in coating efficiency for aerosol sprays while not affecting the quality of droplet formation during spraying. The effect occurs via a dispersed network of fibrous particles in water, providing a weak but useful ability to coat surfaces by responsively adjusting its structure. The material is expected to enable a broad array of applications, from agricultural treatments to nasal sprays, by exhibiting responsive behaviour at concentrations much lower than conventional modifiers require. The project will study the responsiveness of the system in single droplet, spray, and coating form as well as an active delivery system.Read moreRead less