Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100019
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
A transportable containerised laboratory for rapid cell sorting and high-resolution bioimaging of living aquatic microbes in field locations. This project will deliver a transportable, unique laboratory for the rapid isolation and high-resolution analysis of living microbes immediately after sampling from the sea or waterways. It will be the first of its kind in Australia and deliver new knowledge of the role of these organisms in their natural habitats.
The Role of the Single-Cell Environment in Microbial Invasion. This project aims to use a single-cell approach to develop a quantitative analysis of single-cell interactions to advance our understanding of complex bacterial behaviour fundamental to ecology, industry, technology and disease. Bacteria are ubiquitous on Earth and play key roles in nutrient cycles, biogeochemistry, pathogenesis, symbiosis and bioremediation among other processes. They exhibit complex behaviour and continuously invad ....The Role of the Single-Cell Environment in Microbial Invasion. This project aims to use a single-cell approach to develop a quantitative analysis of single-cell interactions to advance our understanding of complex bacterial behaviour fundamental to ecology, industry, technology and disease. Bacteria are ubiquitous on Earth and play key roles in nutrient cycles, biogeochemistry, pathogenesis, symbiosis and bioremediation among other processes. They exhibit complex behaviour and continuously invade animals, plants and new habitats. These behaviours are poorly understood in natural communities.Read moreRead less
New tools to decipher, predict and manage pacific oyster mortality episodes. This project aims to unite cutting-edge genomic and molecular biological tools with novel quantitative modelling analyses to identify the mechanisms behind oyster disease events. Oyster farming contributes almost $100 million to the Australian economy each year and is a cornerstone of coastal communities, but has been decimated by diseases that threaten this important primary industry. While some causative pathogens hav ....New tools to decipher, predict and manage pacific oyster mortality episodes. This project aims to unite cutting-edge genomic and molecular biological tools with novel quantitative modelling analyses to identify the mechanisms behind oyster disease events. Oyster farming contributes almost $100 million to the Australian economy each year and is a cornerstone of coastal communities, but has been decimated by diseases that threaten this important primary industry. While some causative pathogens have been identified, the environmental catalysts of oyster disease remain a mystery. The expected outcome of this project is an innovative coupling of tools that provides new capacity to forecast disease events, delivering the Australian oyster industry a powerful platform to predict, manage and prevent costly disease outbreaks. By identifying environmental thresholds and oyster disease danger periods, an expected outcome of this project is the development of new oyster farming strategies aimed at avoiding multi-million dollar losses associated with disease outbreaks.Read moreRead less
Novel oxygen sensing tools for monitoring the effects of dredging on Australian seagrass communities. Seagrass meadows sustain marine biodiversity and the fishing industries on Australian coasts. Dredging of ports and shipping channels is contributing to their rapid global decline. The project will use state-of-the-art technologies in bio-optics and genomics to create a toolkit for seagrass managers to make informed decisions to safeguard seagrass meadows.
Simultaneous analysis of root-derived plant defences and the associated microbiome. Australia is dependent on sustainable agricultural yields, which need to be maintained or improved. This production capacity is currently under threat by new and existing diseases which are predicted to worsen with climate change. This project will provide a global picture of how disease resistance and soil microbial communities are causally linked, and provide new strategies for disease control. In doing so, it ....Simultaneous analysis of root-derived plant defences and the associated microbiome. Australia is dependent on sustainable agricultural yields, which need to be maintained or improved. This production capacity is currently under threat by new and existing diseases which are predicted to worsen with climate change. This project will provide a global picture of how disease resistance and soil microbial communities are causally linked, and provide new strategies for disease control. In doing so, it will develop intellectual property (IP) and infrastructure that can be used in soil health management. This will provide many benefits to Australia, including sustainable agriculture in the context of climate variability and an increased demand for food, biomaterials and biofuels.Read moreRead less
Fine-scale resolution of genomes in natural microbial communities. This project aims to develop advanced molecular and statistical techniques to precisely resolve the genomes of microbes in the environment. Microbes inhabit every niche on the planet and are fundamental to human and animal health, agriculture, and the environment. The proposed technology will advance our understanding of environmental microbes, leading to advances in areas like climate science and biosecurity where microbes play ....Fine-scale resolution of genomes in natural microbial communities. This project aims to develop advanced molecular and statistical techniques to precisely resolve the genomes of microbes in the environment. Microbes inhabit every niche on the planet and are fundamental to human and animal health, agriculture, and the environment. The proposed technology will advance our understanding of environmental microbes, leading to advances in areas like climate science and biosecurity where microbes play a key role. It will also support the development of billion dollar industries focused on the use of beneficial microbes in agriculture, plant, animal, and human health.Read moreRead less
Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbi ....Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbial diversity patterns and organismal range in Australian marine systems. This is expected to be a crucial step for understanding the evolutionary and ecological processes that shape contemporary biodiversity.Read moreRead less
Microbiology of a tropical creek impacted by sewage effluent: novel assessment using N-cycle functional markers and changes in community composition. Although most of Darwin Harbour has good water quality, there is much concern about local 'hot spots' where sewage has degraded ecosystem processes and values. As no bio-indicators of tropical marine water and sediment quality are known, the project will identify functional markers and microbial indicators of stress for integrated environmental mo ....Microbiology of a tropical creek impacted by sewage effluent: novel assessment using N-cycle functional markers and changes in community composition. Although most of Darwin Harbour has good water quality, there is much concern about local 'hot spots' where sewage has degraded ecosystem processes and values. As no bio-indicators of tropical marine water and sediment quality are known, the project will identify functional markers and microbial indicators of stress for integrated environmental monitoring.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100021
Funder
Australian Research Council
Funding Amount
$2,700,000.00
Summary
Building virtual cyanobacteria: moving beyond the genomics era. Building virtual cyanobacteria: moving beyond the genomics era. This project aims to establish a new understanding of complex biological systems through the development of computational models of single cells and global ecosystems. The project will focus on globally important photosynthetic bacteria that underlie the entire marine food web. This project aims to characterise the diversity and abundance of photosynthetic bacteria acro ....Building virtual cyanobacteria: moving beyond the genomics era. Building virtual cyanobacteria: moving beyond the genomics era. This project aims to establish a new understanding of complex biological systems through the development of computational models of single cells and global ecosystems. The project will focus on globally important photosynthetic bacteria that underlie the entire marine food web. This project aims to characterise the diversity and abundance of photosynthetic bacteria across Australia's marine habitats and unravel the genetic basis for their adaptation to different environments. This data will be integrated with biochemical and physiological studies to create quantitative models at the cellular and global ecosystem scales. This project aims to develop new biomonitoring technologies, which combined with these models, will enable assessment of the health of Australia's marine ecosystems.Read moreRead less
Do binding proteins allow cyanobacteria to scavenge diverse nutrients? Marine cyanobacteria are abundant primary producers that underlie the entire marine food web. They encode a diverse range of predicted nutrient uptake systems that are highly conserved, suggesting these transporters play critical roles in their success in diverse marine ecosystems. However, there is very limited data regarding their function, specificity and ecological importance. Using our pioneering combinatorial approach, ....Do binding proteins allow cyanobacteria to scavenge diverse nutrients? Marine cyanobacteria are abundant primary producers that underlie the entire marine food web. They encode a diverse range of predicted nutrient uptake systems that are highly conserved, suggesting these transporters play critical roles in their success in diverse marine ecosystems. However, there is very limited data regarding their function, specificity and ecological importance. Using our pioneering combinatorial approach, we will undertake systematic functional characterisation of these nutrient uptake systems and determine their physiological and ecological importance. Our integrative science will provide a molecules-to-ecosystems understanding of cyanobacterial nutrient acquisition.Read moreRead less