Advancing The Evidence-base For Childhood Brain Insult: Diagnosis, Assessment And Intervention
Funder
National Health and Medical Research Council
Funding Amount
$575,662.00
Summary
My research has 4 primary objectives, representing major gaps in current knowledge: 1. improve knowledge of recovery and determinants of post-concussive symptoms 2. establish the impact of child brain insult on socio-emotional function and identify contributing factors 3. develop an iPad based tool for socio-emotional function 4. evaluate and disseminate e-heath treatments for child brain insult
Multiple Sclerosis (MS) is an autoimmune disease often diagnosed in early adulthood. Outcomes very enormously, from mild to disabling. This fellowship supports research to improve outcome prediction using genetics and to examine different strategies to optimise treatment outcomes and safety. The main data source is MSBase, which tracks over 31000 people with MS globally and is based in the University of Melbourne's brain Centre at the Royal Melbourne Hospital.
Clinical Trials And Registries To Prevent Blindness For Macular Disease
Funder
National Health and Medical Research Council
Funding Amount
$467,961.00
Summary
Injection of drugs into the eye is an unprecedented breakthrough in the treatment of macular diseases, however many questions must be addressed for our patients with diabetic retinopathy and macular degeneration to reap the full benefits. My clinical research unit will conduct our own clinical trials, such as testing a new laser that has never been used in the retina. My observational studies unit will track “real world” outcomes of treatment of retinal disease in a large group of Australians.
Conducting Clinical Research In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$569,219.00
Summary
The burden of Chronic Kidney Disease (CKD) is large, increasing, and ultimately unsustainable. One in ten Australians have CKD which puts them at higher risk of cardiovascular disease and cancer, and a higher likelihood of an early death. CKD also has a negative impact on people's lifestyles and relationships. Practitioner Fellowship support will allow me relief from my clinical commitments to invest in promising lines of new enquiry to support people with CKD and their carers.
Improved Patient Outcomes By Early Intervention With Therapeutic Cooling For Patients With Severe Traumatic Brain Injury, And By Optimising Patient Blood Transfusion Practice In Critically Ill Patients.
Funder
National Health and Medical Research Council
Funding Amount
$380,450.00
Summary
First, a large multicentre trial (POLAR) will complement my previous successful trials in traumatic brain injury (TBI) patients and will establish whether active therapeutic cooling, commenced early after brain injury and continued in intensive care units, will achieve its promise of improving patient outcomes. Second, a national multicentre trial (TRANSFUSE) will establish whether transfusing blood units with a shorter than usual storage time will improve patient outcomes.
Improving Outcomes For Critically Ill Patients After Traumatic Brain Injury And Blood Transfusion
Funder
National Health and Medical Research Council
Funding Amount
$418,049.00
Summary
The Fellowship will support an academic clinician to lead the Alfred Intensive Care Department, and the Monash ANZIC Research Centre. Two pivotal NHMRC supported clinical trials, led by the Fellow, are each the largest and most definitive trials in their fields, and will complete during Fellowship and provide extensive data for research outputs. Concurrently, a new research program to improve patients function and quality of life after critical illness, will be supported.
Researching Functioning, Disability And Rehabilitation
Funder
National Health and Medical Research Council
Funding Amount
$387,469.00
Summary
The research program investigates the causes and treatments that help people overcome disability and improve functioning, particularly in life areas such as home, family, community and work.