Pathophysiological mechanisms in equine dyschondroplasia (osteochondrosis). Dyschondroplasia (osteochondrosis) is a developmental orthopaedic disease of horses, which causes significant wastage within the Thoroughbred racing industry. The disease affects growth cartilage beneath joint surfaces in such a way that cartilage fails to be replaced by bone, resulting in defects in the joint surface and lameness. This project will identify differences in gene expression between normal cartilage and ea ....Pathophysiological mechanisms in equine dyschondroplasia (osteochondrosis). Dyschondroplasia (osteochondrosis) is a developmental orthopaedic disease of horses, which causes significant wastage within the Thoroughbred racing industry. The disease affects growth cartilage beneath joint surfaces in such a way that cartilage fails to be replaced by bone, resulting in defects in the joint surface and lameness. This project will identify differences in gene expression between normal cartilage and early dyschondroplastic lesions, in order to identify the sequence of molecular events leading to induction of disease. The basic understanding of joint development obtained from this work will assist in the development of strategies to prevent and diagnose dyschondroplasia in horses.Read moreRead less
Molecular characterization of stem cell differentiation and oocyte maturation using synchrotron infrared spectroscopy and Atomic Force Microscopy/Raman imaging. There are currently no molecular based methods to assess oocyte maturation and stem cell differentiation at the single cell level. Consequently the need for such techniques is critical in placing Australia at the forefront in this rapidly expanding field. Such technology would give Australia a leading edge in stem cell and oocyte researc ....Molecular characterization of stem cell differentiation and oocyte maturation using synchrotron infrared spectroscopy and Atomic Force Microscopy/Raman imaging. There are currently no molecular based methods to assess oocyte maturation and stem cell differentiation at the single cell level. Consequently the need for such techniques is critical in placing Australia at the forefront in this rapidly expanding field. Such technology would give Australia a leading edge in stem cell and oocyte research and ultimately assist in discovering disease cures for debilitating neurodegenerative diseases and spinal chord injury, while techniques for determining the viability of oocytes may have important implications for future in vitro fertilization programs. The intellectual property and technologies developed from this research could also have potential to impact on the global market.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668479
Funder
Australian Research Council
Funding Amount
$265,000.00
Summary
Advanced Imaging Flow Cytometry Facility for NSW. The scientific advances that will be possible with the acquisition of this novel, cutting-edge instrument will enhance the research outputs of all investigators using it. Projects where the investigation of single cells is used to elucidate the basic life processes of eukaryotic cells across all species of animals, including the investigation of both normal and abnormal function, will be immeasurably enhanced by both the qualitative and quantitat ....Advanced Imaging Flow Cytometry Facility for NSW. The scientific advances that will be possible with the acquisition of this novel, cutting-edge instrument will enhance the research outputs of all investigators using it. Projects where the investigation of single cells is used to elucidate the basic life processes of eukaryotic cells across all species of animals, including the investigation of both normal and abnormal function, will be immeasurably enhanced by both the qualitative and quantitative statistical information about these processes that is generated by this instrument. This in turn will inform new approaches to improve and maintain the health of the human and animal community.Read moreRead less