Platelet Derived Growth Factor Mediated Activation And Rejuvenation Of Endogenous Cardiac Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$102,345.00
Summary
The burden of heart failure is underpinned by the heart’s limited capacity for self-repair after injury. Recent evidence shows that PDGF can improve heart function by activating and rejuvenating resident heart stem cells. This project will build on over a decade of preliminary work in mice, validating our results in a preclinical large animal model. Outcomes of this project include expedited progression of this promising therapy where thousands of heart failure patients could one-day benefit.
'One Health Ethics': A Critical Examination Of The Use, Regulation And Prohibition Of Animals As Medicines In Complementary And Traditional Medicinal Systems
Funder
National Health and Medical Research Council
Funding Amount
$97,419.00
Summary
Use of traditional, complementary and alternative medicines (TCAM), including animal therapies such as shark cartilage, is growing in Australia despite controversy over its benefits and harms. This research seeks to engage with communities and stakeholders to better understand how and why animals are used as therapies in Australia. The research will inform a more lateral approach to preventing the use of animals in TCAM or at the very least ensuring that their use is sustainable and ethically ac ....Use of traditional, complementary and alternative medicines (TCAM), including animal therapies such as shark cartilage, is growing in Australia despite controversy over its benefits and harms. This research seeks to engage with communities and stakeholders to better understand how and why animals are used as therapies in Australia. The research will inform a more lateral approach to preventing the use of animals in TCAM or at the very least ensuring that their use is sustainable and ethically acceptable.Read moreRead less
This project aims to comprehensively evaluate the role of androgen receptor (AR) signalling in breast cancer by identifying changes in AR signalling and its role in an endocrine resistant setting. Understanding the changes in AR signalling in either treatment-naive or treatment-resistant context would better assist in the identification for opportunities to modulate AR signalling as a therapeutic target in breast cancer.
Exploring Knowledge Translation In Indigenous Primary Health Care
Funder
National Health and Medical Research Council
Funding Amount
$93,741.00
Summary
New knowledge is needed about how to implement effective interventions and strengthen Indigenous primary health care systems. This study will explore how new knowledge gets implemented (or doesnÍt), for whom, and under what circumstances in Indigenous primary health care contexts. It will be the first study to look at how evidence, context and facilitation elements influence the implementation of research into Indigenous primary health care practice and policy.
The Incidence And Outcomes Of Chronic Kidney Disease Amongst Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$140,120.00
Summary
The aim of this body of work is to improve understanding of the incidence and outcomes of chronic kidney disease for Indigenous Australians, in order to try to better predict outcomes and guide clinical and policy-level decision making.
Individualising Care For Patients With Chronic Hepatitis C: Predicting Side Effects And Treatment Response Using Genomic And Proteomic Approaches.
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially impro ....Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially improving the safety and efficacy of therapy.Read moreRead less
An Ethical Analysis Of Breast Cancer Screening In Australia To Inform Future Practice
Funder
National Health and Medical Research Council
Funding Amount
$137,700.00
Summary
Breast cancer screening is an important part of Australia’s focus on promoting good health. There is, however, increasing confusion about how screening should be offered and some concern about the potential harms of screening. I will analyse the development of breast screening in Australia with a particular focus on ethics, will empirically study current screening practices, and make recommendations about how we should progress in future to ensure that the breast screening program is as ethicall ....Breast cancer screening is an important part of Australia’s focus on promoting good health. There is, however, increasing confusion about how screening should be offered and some concern about the potential harms of screening. I will analyse the development of breast screening in Australia with a particular focus on ethics, will empirically study current screening practices, and make recommendations about how we should progress in future to ensure that the breast screening program is as ethically sound as possible.Read moreRead less
Standardised Outcomes In Nephrology – Peritoneal Dialysis (SONG-PD): Establishing A Core Outcome Set In Peritoneal Dialysis
Funder
National Health and Medical Research Council
Funding Amount
$66,502.00
Summary
Standardised Outcomes in Nephrology-Peritoneal Dialysis study aims to establish a set of core outcomes for trials in PD based on the shared priorities of all stakeholders, so that outcomes of most relevance for decision making can be evaluated, and that interventions can be compared reliably.
Building A Bridge Between Animal Models Of Blood Transfusion And Clinical Practice: Development Of Sheep Laboratory Models To Investigate The Effects Of Transfusion
Funder
National Health and Medical Research Council
Funding Amount
$86,117.00
Summary
This research project aims to develop clinically-relevant sheep laboratory models of transfusion that will provide a ‘bridge’ between human laboratory and sheep in vivo models and clinical setting by contributing to a better understanding of the underlying mechanisms of transfusion with stored blood products. Ultimately, addressing key knowledge gaps regarding transfusion of aged and cryopreserved blood products will result in improved outcomes for patients.
Understanding Predictors Of Fatigue After Brain Injury In Children.
Funder
National Health and Medical Research Council
Funding Amount
$98,459.00
Summary
This research will examine what factors predict the fatigue children will experience after brain injury. This study is important because fatigue is one of the most commonly reported and challenging symptoms after traumatic brain injury. It significantly impacts on well being and quality of life after injury. We will assess fatigue of 120 children who suffer brain injury, from Toronto and Melbourne. This study will improve our understanding of the factors that predict fatigue following brain inju ....This research will examine what factors predict the fatigue children will experience after brain injury. This study is important because fatigue is one of the most commonly reported and challenging symptoms after traumatic brain injury. It significantly impacts on well being and quality of life after injury. We will assess fatigue of 120 children who suffer brain injury, from Toronto and Melbourne. This study will improve our understanding of the factors that predict fatigue following brain injury.Read moreRead less