A thermodynamic pathway to intracellular delivery. Cells transmit information through molecules. By delivering foreign molecules into cells, such as DNA and proteins, it is possible to engineer and reprogram cells just like a computer. This proposal aims to develop a novel microfluidic device for intracellular delivery. The device will work by exposing cells to rapid thermal shock to generate transient disruptions in cell membranes and thereby enable influx of foreign molecules into cells. To un ....A thermodynamic pathway to intracellular delivery. Cells transmit information through molecules. By delivering foreign molecules into cells, such as DNA and proteins, it is possible to engineer and reprogram cells just like a computer. This proposal aims to develop a novel microfluidic device for intracellular delivery. The device will work by exposing cells to rapid thermal shock to generate transient disruptions in cell membranes and thereby enable influx of foreign molecules into cells. To understand how the method can be optimized, the thermodynamic pathway of membrane disruption will be investigated at a single cell level. The methods and insights arising from this project could eventually lead to novel, patentable and lower-cost health technologies.Read moreRead less
RoboCrab: An integrative approach to the natural ecology of decision making. The project aims to analyse and model the sophisticated and context-dependent escape behaviour of fiddler crabs under both natural conditions and in controlled laboratory settings. A crucial problem for biology is to understand how animals can make adaptive decisions in natural, complex sensory environments; such understanding also has direct application to robotics. The project plans to examine the effects of eye stabi ....RoboCrab: An integrative approach to the natural ecology of decision making. The project aims to analyse and model the sophisticated and context-dependent escape behaviour of fiddler crabs under both natural conditions and in controlled laboratory settings. A crucial problem for biology is to understand how animals can make adaptive decisions in natural, complex sensory environments; such understanding also has direct application to robotics. The project plans to examine the effects of eye stabilisation and oscillation, record from key neural stages using naturalistic stimuli to derive precise algorithms, and integrate and test the results on a robot model – RoboCrab. This may provide new insight into the integration of low-level sensory input with behavioural decision making circuits and the evolution of escape behaviours.Read moreRead less
Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to ....Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to utilise these findings to improve the control of neuronal excitability, for development of interfaces with the nervous system.Read moreRead less
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less
Liquefaction of silty soils: Micromechanics, modelling and prediction. The project aims to develop a numerical approach to understand liquefaction in silty soils. Liquefaction of silty soils in submarine landslides, mine tailings dam failures and cargo liquefaction in vessels carrying iron/nickel ores can cause property loss and be fatal. This project will bridge the behaviours across the scales and deliver constitutive models that possess grain scale mechanisms for better prediction of liquefac ....Liquefaction of silty soils: Micromechanics, modelling and prediction. The project aims to develop a numerical approach to understand liquefaction in silty soils. Liquefaction of silty soils in submarine landslides, mine tailings dam failures and cargo liquefaction in vessels carrying iron/nickel ores can cause property loss and be fatal. This project will bridge the behaviours across the scales and deliver constitutive models that possess grain scale mechanisms for better prediction of liquefaction induced failure at the large scales. The expected outcomes are liquefaction criteria for silty soils with different silt contents and numerical tools to predict the onset of liquefaction and flow of liquefied soils.Read moreRead less
Advanced adsorbents for gas separations. Efficient purification of natural gas and separation of similarly-sized molecules in gas mixtures is increasingly important in our drive to develop a more sustainable way of living in an energy-constrained world. This project will develop a new class of adsorbents to deliver a level of separation efficiency much higher than that currently in use.
Smart materials from semi-soft particles. This project will combine precision polymer chemistry to material science to develop structured nanoparticles for applications in photonics and shape memory materials.
Maximising value in underground mine planning. Mining is crucial to Australia’s economy, contributing 8 per cent of GDP and 55 per cent of the value of goods exported. Working with mining companies Rand and Tribune, this project tackles issues faced in underground mine planning. While integrated optimisation of design and production in open cut mining is well established, no equivalent capability is available for underground mines. This project aims to develop innovative techniques to optimise t ....Maximising value in underground mine planning. Mining is crucial to Australia’s economy, contributing 8 per cent of GDP and 55 per cent of the value of goods exported. Working with mining companies Rand and Tribune, this project tackles issues faced in underground mine planning. While integrated optimisation of design and production in open cut mining is well established, no equivalent capability is available for underground mines. This project aims to develop innovative techniques to optimise the design of the access network and the production scheduling in an underground mine in order to maximise value over the life of the operation. The outcome intends to be a new strategic software tools for the sector, underpinning increased efficiency and sustainability of Australian mines as well as international competitiveness.Read moreRead less
Certified evaluation of uncertainty in models of dynamical systems. The purpose of this project is to develop methods which will aid engineers to better analyse the accuracy of models created using experimental data. To support the use of the methods, a toolbox with software implementations will also be developed.
Soft materials containing hierarchy via 3D sacrificial micro-moulding. The project seeks to develop sophisticated new polymeric materials and devices not possible using current manufacturing techniques. Biomaterials based on hydrogels are ideal substrates for synthetic extra-cellular matrices due to their high water content. However, one of the challenges hindering the use of hydrogels is reproducing the transport properties found in natural tissue with hierarchical features such as vascularisat ....Soft materials containing hierarchy via 3D sacrificial micro-moulding. The project seeks to develop sophisticated new polymeric materials and devices not possible using current manufacturing techniques. Biomaterials based on hydrogels are ideal substrates for synthetic extra-cellular matrices due to their high water content. However, one of the challenges hindering the use of hydrogels is reproducing the transport properties found in natural tissue with hierarchical features such as vascularisation. To address this, the project plans to develop a 3D moulding process for generating soft materials containing precise channels decorated with defined molecules. Intended outcomes include a fundamental understanding of the 3D moulding process, and new polymers and advanced tools for bioengineers for future applications such as tissue transplants, cell guides for treating spinal cord injuries, soft robotics and microfluidic devices to study cancer metastasis. Read moreRead less