Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpt ....Cellular and network basis of information processing in the mammalian visual system. The project aims to discover the strategies by which cells in the brain interact with each other to code the sensory input efficiently. It is expected that simultaneous recording of the activity of many neurones from the visual cortex of anaesthetised cats during visual stimulation will reveal how the biophysics of synaptic integration combined with excitatory and inhibitory inputs from different sources sculpts the output of individual neurones. The experiments will be extended to the study of possible interactions between different areas of the brain and the study of mechanisms by which the cortical network and higher cognitive factors such as attention and memory might influence the coding of sensory information in awake animals.Read moreRead less
Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four ne ....Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four neuronal cell cultures established with gene-based selection criteria. These cultures will be characterised by gene expression, immunocytochemistry, radiolabelled neurotransmitter release, electrophysiology and Ca2+ imaging studies. This study will highlight the functional effects of gene selection procedures upon stem cell-derived neurons.Read moreRead less
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
Mary Astell (1666-1731): An Historical-Intellectual Role Model for Women in Philosophy. Mary Astell was an early modern English philosopher of exceptional eloquence and skill. This project will produce the first overview of her philosophical thought, the first authoritative critical edition of her magnum opus, and the first assessment of her philosophical relevance today. These outputs have the potential to encourage women's participation in philosophy and in intellectual life more generally, ou ....Mary Astell (1666-1731): An Historical-Intellectual Role Model for Women in Philosophy. Mary Astell was an early modern English philosopher of exceptional eloquence and skill. This project will produce the first overview of her philosophical thought, the first authoritative critical edition of her magnum opus, and the first assessment of her philosophical relevance today. These outputs have the potential to encourage women's participation in philosophy and in intellectual life more generally, outcomes that would be of tremendous benefit to Australia's social and economic fabric. The project will also enhance Australia's already outstanding scholarly reputation for early modern studies and the history of women's ideas.Read moreRead less
Mereological Composition and Material Constitution. This project embodies a number of advances in metaphysics, which is a field of research in which Australia enjoys a considerable international reputation. Our work on material constitution will also further Australia's reputation in the philosophy of mind; some of the most celebrated 20th Century contributions in the philosophy of mind have been written by Australian philosophers.
Value Adding to Australian Cashmere Fleece. This project will lead to major technical advance in the processing of both cashmere fibres and cashmere guard hair. Reducing the level of breakage in fine cashmere fibres will add significant premium to the price of cashmere fibres and products. In addition, the large amount of coarse guard hair removed from cashmere dehairing process will be converted into quality fine powders, which will add significant value to an otherwise 'waste' product. This pr ....Value Adding to Australian Cashmere Fleece. This project will lead to major technical advance in the processing of both cashmere fibres and cashmere guard hair. Reducing the level of breakage in fine cashmere fibres will add significant premium to the price of cashmere fibres and products. In addition, the large amount of coarse guard hair removed from cashmere dehairing process will be converted into quality fine powders, which will add significant value to an otherwise 'waste' product. This project will benefit the entire animal fibre industry, particularly the rare animal fibre industry.Read moreRead less
A model of the mind which explains the role of emotions in normal cognition and affective disorder. Depression is recognised as one of the most burdensome diseases in Australia. Though we of course make no claims, as philosophers, to cure depression our contribution is to engage philosophy productively with a vital national area of empirical research. The other area of national benefit is to consolidate Australia's developing reputation as a site for the involvement of philosophy in interdiscipl ....A model of the mind which explains the role of emotions in normal cognition and affective disorder. Depression is recognised as one of the most burdensome diseases in Australia. Though we of course make no claims, as philosophers, to cure depression our contribution is to engage philosophy productively with a vital national area of empirical research. The other area of national benefit is to consolidate Australia's developing reputation as a site for the involvement of philosophy in interdisciplinary projects which link the humanities to the sciences. Furthermore, with the project's anchoring in the humanities, there is hope that a focus on, and increased understanding of, depression will have flow-on effects in the Australian community that will help ease the stigmatisation that is still felt by many of its sufferers.Read moreRead less
Models of Divinity. At a time of religious conflict around the world, interfaith dialogue is becoming increasingly important. This project will provide a platform for such dialogue to take place, thus advancing the National Research Priority Goal of improving Australia's capacity to interpret and engage with its regional and global environment. The project will also have distinct social benefits that will result from exploring the links between competing conceptions of the divine and (very often ....Models of Divinity. At a time of religious conflict around the world, interfaith dialogue is becoming increasingly important. This project will provide a platform for such dialogue to take place, thus advancing the National Research Priority Goal of improving Australia's capacity to interpret and engage with its regional and global environment. The project will also have distinct social benefits that will result from exploring the links between competing conceptions of the divine and (very often oppressive) social-cultural practices. Finally, the project will advance Australia's reputation and standing in the philosophy of religion, thus stimulating greater postgraduate and postdoctoral research in this area. Read moreRead less
Two-Dimensional Semantics and the Foundations of Philosophy. This project investigates fundamental philosophical questions concerning the relation between our minds and the world and the possibility of rational inquiry. The project represents a significant advance in the theoretical understanding of a broad range of central philosophical issues and it has important implications for the nature and methods of scientific inquiry. The project will contribute to the international research profile of ....Two-Dimensional Semantics and the Foundations of Philosophy. This project investigates fundamental philosophical questions concerning the relation between our minds and the world and the possibility of rational inquiry. The project represents a significant advance in the theoretical understanding of a broad range of central philosophical issues and it has important implications for the nature and methods of scientific inquiry. The project will contribute to the international research profile of Australia, consolidating its place as a leader in this domain. Read moreRead less
The Criticism of Heaven and Earth. Two issues have returned with vigour to public debate: the role of religion in secular society and the relation between theology and political theory. This project provides a much needed reference work that sets the current debates within a long and rich tradition. Apart from enabling us to avoid the mistakes of the past, it also brings to the fore forgotten solutions to such issues. Further, given the central role of many of these critics in a range of discipl ....The Criticism of Heaven and Earth. Two issues have returned with vigour to public debate: the role of religion in secular society and the relation between theology and political theory. This project provides a much needed reference work that sets the current debates within a long and rich tradition. Apart from enabling us to avoid the mistakes of the past, it also brings to the fore forgotten solutions to such issues. Further, given the central role of many of these critics in a range of disciplines, the series will have repercussions across a wide range of discussions within Australia and abroad. Finally, is a further step in international leadership emanating from Australia.Read moreRead less