Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989859
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistr ....A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation. X-ray microtomography platforms are applicable to a wide diversity of research across many of the national research priority areas. The research outlined will provide insights into bone cancer and osteoporosis, promote breakthroughs in the understanding of tumour biology and drive new developments in novel biomaterials, all of which have significant national health benefits. In dentistry, research supported by this instrumentation will provide Australians with improvements to their dental health. Furthermore applications to industrial materials are providing Australian industries with better characterisation of their products that is leading to improved export performance and consequent improvement in Australia's balance of trade.Read moreRead less
Deep Downunder: designing a deep-sea exploration and discovery capability for Australia. Exploration of the deep-sea with the modern technologies to be developed by Deep-Downunder is a first for Australia. We aim to explore and discover life at depths from 50-3000m off The Great Barrier Reef, around the seamounts of Lord Howe Island and Tasmania and in the deep canyons of WA and SA. We expect to discover new species, hope for a glimpse of giant squid at home and will answer specific questions on ....Deep Downunder: designing a deep-sea exploration and discovery capability for Australia. Exploration of the deep-sea with the modern technologies to be developed by Deep-Downunder is a first for Australia. We aim to explore and discover life at depths from 50-3000m off The Great Barrier Reef, around the seamounts of Lord Howe Island and Tasmania and in the deep canyons of WA and SA. We expect to discover new species, hope for a glimpse of giant squid at home and will answer specific questions on Australia's ocean biology, fisheries and biotechnology never before approachable. To be effective guardians of Australian waters we must learn what lies in the depths we can't see from a boat.Read moreRead less
Colour vision and photoreceptors in reef fish: a model system to discover the function of double cones. Humans are visual animals and as lucky Australians we love to look at The Great Barrier Reef. This project, while rooted in the complexities of visual neurobiology, uses a recently discovered set of 4 different reef fish from the GBR to teach us more about fundamental principles in vision. These fish, diverse as damselfish and snappers, will help solve a mystery centuries old. Double cones are ....Colour vision and photoreceptors in reef fish: a model system to discover the function of double cones. Humans are visual animals and as lucky Australians we love to look at The Great Barrier Reef. This project, while rooted in the complexities of visual neurobiology, uses a recently discovered set of 4 different reef fish from the GBR to teach us more about fundamental principles in vision. These fish, diverse as damselfish and snappers, will help solve a mystery centuries old. Double cones are the commonest daytime photoreceptor in the eyes of almost all vertebrates (humans without them are exceptions) and yet nobody knows what they do. Reef fish have them, so let's ask them what they see!Read moreRead less
Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four ne ....Neurons isolated from embryonic stem cells as functional models for drug discovery. By using gene expression-based selection criteria embryonic stem cells can be driven to differentiate into specific neuronal lineages which show many of the morphological characteristics and immunocytochemical features of neurons in culture. There is, however, comparatively little evidence indicating that these stem cell-derived neurons actually behave as neurons. Our aim is to characterise and contrast four neuronal cell cultures established with gene-based selection criteria. These cultures will be characterised by gene expression, immunocytochemistry, radiolabelled neurotransmitter release, electrophysiology and Ca2+ imaging studies. This study will highlight the functional effects of gene selection procedures upon stem cell-derived neurons.Read moreRead less