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The Role of C-kit and Selected TGF beta Family Members in Recruitment. The recruitment of primordial follicles into the growth phase is central to female reproductive function, however the control of this process to date, has been poorly understood due to inadequate technologies. Our team has recently developed novel recruitment models and a new and innovative method of isolating primordial follicles which will enable us to identify the role of c-kit and selected TGF beta family members in recru ....The Role of C-kit and Selected TGF beta Family Members in Recruitment. The recruitment of primordial follicles into the growth phase is central to female reproductive function, however the control of this process to date, has been poorly understood due to inadequate technologies. Our team has recently developed novel recruitment models and a new and innovative method of isolating primordial follicles which will enable us to identify the role of c-kit and selected TGF beta family members in recruitment. This work will provide cornerstone scientific knowledge about the control of female reproduction and provide the impetus for the development of more effective contraception and superovulation strategies in mammals.Read moreRead less
Defining the impact of Environmental Endocrine Disruptors on the sustainability of
Australia’s Native Marsupials. Environmental endocrine disrupting chemicals (EEDs) from introduced plants, pesticides and wastewater are dramatically increasing in the Australian environment. EEDs have been shown to cause dramatic reproductive and developmental abnormalities in vertebrates ranging from fish to humans. This project plans to investigate the impact that these chemicals might have on marsupial devel ....Defining the impact of Environmental Endocrine Disruptors on the sustainability of
Australia’s Native Marsupials. Environmental endocrine disrupting chemicals (EEDs) from introduced plants, pesticides and wastewater are dramatically increasing in the Australian environment. EEDs have been shown to cause dramatic reproductive and developmental abnormalities in vertebrates ranging from fish to humans. This project plans to investigate the impact that these chemicals might have on marsupial development. Marsupials have a unique reproductive strategy and how this might affect their ability to respond to EEDs is unknown. This project aims to define the effects of three of the predominant EED risks for marsupials in the Australian environment; estradiol, genistein and atrazine.Read moreRead less