Chronic Kidney Diseases (CKDs) present serious morbidity and mortality in our society. Kidney scarring is the final manifestation of many types of kidney diseases. Recent evidence showed that a reduced ability to generate energy during injuries leads to kidney scarring. My study is looking at how the specific changes in kidney energy production can lead to kidney scarring. The findings of my study can have potential to prevent kidney scarring and change the course of kidney diseases.
The Role Of Fatty Acid Metabolism In Renin Secretion
Funder
National Health and Medical Research Council
Funding Amount
$582,294.00
Summary
People who are overweight often have high blood pressure. This project aims to find out why. By showing that the kidneys, which control blood pressure, use fat as an important controller of their function, we may be able to work out ways to modify the relationship between obesity and high blood pressure. The project wil be performed in genetically modified mice, but we expect that the findings will be applicable to humans.