Circular RNAs As Genome Destabilisers In Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Mutation of genes are hallmarks of both cancer and neurological disorders. My research group has identified roles for circular RNAs in both these processes. Now, we must close the loop by investigating the mechanism of these processes. This will inform not only why these genes are commonly mutated, but by exploiting the highly stable circular RNAs they may provide early prognostic/diagnostic biomarkers and even represent novel therapeutic targets for cancer and Huntington’s disease.
Australian Laureate Fellowships - Grant ID: FL200100049
Funder
Australian Research Council
Funding Amount
$2,906,992.00
Summary
Nanofluidic Membranes for Sustainable Energy Future. This project aims to create a novel class of advanced membranes by making fundamental breakthroughs in nanofluidics, and harnessing this for developing new renewable energy and low-energy separation technologies. This project addresses the key challenges in understanding selective mass transport at the angstrom scale, thereby allowing the development of innovative materials design strategies to realise the ultrafast molecular and ionic permeat ....Nanofluidic Membranes for Sustainable Energy Future. This project aims to create a novel class of advanced membranes by making fundamental breakthroughs in nanofluidics, and harnessing this for developing new renewable energy and low-energy separation technologies. This project addresses the key challenges in understanding selective mass transport at the angstrom scale, thereby allowing the development of innovative materials design strategies to realise the ultrafast molecular and ionic permeation, and the ultrahigh selectivities observed in biological cell membranes. This new cross-disciplinary research will benefit Australia by the development of new materials for accelerating renewable hydrogen and biofuel futures, and enabling sustainable production of energy materials.Read moreRead less
Phase stability of biomass fast pyrolysis bio-oil: behaviour and control. This project aims to carry out a systematic investigation into the phase behaviour and control of biomass fast pyrolysis into bio-oil and its derived fuels. The project addresses the major problem of fuel phase separation during processing and handling that cause significant operational challenges, for example pumping difficulties and line clogging, during storage, transport and applications of these fuels. The outcomes in ....Phase stability of biomass fast pyrolysis bio-oil: behaviour and control. This project aims to carry out a systematic investigation into the phase behaviour and control of biomass fast pyrolysis into bio-oil and its derived fuels. The project addresses the major problem of fuel phase separation during processing and handling that cause significant operational challenges, for example pumping difficulties and line clogging, during storage, transport and applications of these fuels. The outcomes include the discovery of fundamental knowledge on the phase structure, stability and behaviour of the products of biomass fast pyrolysis bio-oil and its derived fuels and the development of essential engineering tools for predicting and controlling phase behaviour and stability of these fuels.Read moreRead less
Thermal transport by design for fast and efficient solar thermochemical fuel production. This project aims to demonstrate the utility of the thermal transport by design approach to develop functionally graded reactive materials that allow for fast and efficient solar thermo-chemical fuel production. Prediction capabilities will be developed to optimise multi-scale radiative and gas transport coupled with non-stoichiometric redox reactions. Synthesis gas production will be demonstrated using the ....Thermal transport by design for fast and efficient solar thermochemical fuel production. This project aims to demonstrate the utility of the thermal transport by design approach to develop functionally graded reactive materials that allow for fast and efficient solar thermo-chemical fuel production. Prediction capabilities will be developed to optimise multi-scale radiative and gas transport coupled with non-stoichiometric redox reactions. Synthesis gas production will be demonstrated using the new structures in a prototype solar thermochemical reactor under high-flux irradiation. This project aims to advance the fields of thermal sciences and high-temperature solar thermochemical processing and expand the engineering knowledge base to pave the way to sustainable transportation with the existing infrastructure.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC200100023
Funder
Australian Research Council
Funding Amount
$4,920,490.00
Summary
ARC Training Centre for The Global Hydrogen Economy. The centre aims to transform Australia into a hydrogen powerhouse by building enabling capacity in hydrogen innovation in a short timeframe. Australia is well-positioned to capitalise on the emerging global growth of hydrogen, however to be competitive and produce at scale, we need cost-effective hydrogen technologies and capabilities for transitioning hydrogen into industries. This innovative, five-year program will generate new technologies ....ARC Training Centre for The Global Hydrogen Economy. The centre aims to transform Australia into a hydrogen powerhouse by building enabling capacity in hydrogen innovation in a short timeframe. Australia is well-positioned to capitalise on the emerging global growth of hydrogen, however to be competitive and produce at scale, we need cost-effective hydrogen technologies and capabilities for transitioning hydrogen into industries. This innovative, five-year program will generate new technologies and equip a future workforce of industry-focused engineers with advanced skills for development and scaling-up of hydrogen generation and transport. Benefits include: export of hydrogen fuel and advanced technologies; job creation; and a lower emissions domestic energy industry.Read moreRead less
The role of phospholipids in the biogenesis of lipid droplets. The general aim is to elucidate the fundamental molecular mechanisms that govern the biogenesis/formation of the lipid droplets. Lipid droplets store sterol esters and/or triacylglycerols, two major storage lipids that play key roles in cellular and whole body lipid metabolism. Lipid droplets are also the core components of plant oil and biodiesel. Little is known about how lipid droplets are generated. The proposed work will examine ....The role of phospholipids in the biogenesis of lipid droplets. The general aim is to elucidate the fundamental molecular mechanisms that govern the biogenesis/formation of the lipid droplets. Lipid droplets store sterol esters and/or triacylglycerols, two major storage lipids that play key roles in cellular and whole body lipid metabolism. Lipid droplets are also the core components of plant oil and biodiesel. Little is known about how lipid droplets are generated. The proposed work will examine the synthesis of certain lipid intermediates such as phosphatidic acid, and their impact on the biogenesis of lipid droplets from the endoplasmic reticulum. Such fundamental new knowledge on how cells store neutral lipids will provide new strategies for enhancing plant oil and biodiesel production. Read moreRead less
Advanced Proton-Conducting Ceramic FCs for Power Generation from Ammonia . The project aims to design an innovative ammonia fuel cell using a new perovskite substrate decorated with metal nanoparticles, which demonstrates multi-functionalities and tackles most challenges of conventional fuel cells (FCs). The key concept of this project is the designing of the novel architected smart perovskite as both anode and electrolyte of the fuel cell by systematic modelling and experimental development. T ....Advanced Proton-Conducting Ceramic FCs for Power Generation from Ammonia . The project aims to design an innovative ammonia fuel cell using a new perovskite substrate decorated with metal nanoparticles, which demonstrates multi-functionalities and tackles most challenges of conventional fuel cells (FCs). The key concept of this project is the designing of the novel architected smart perovskite as both anode and electrolyte of the fuel cell by systematic modelling and experimental development. The versatile cell components developed in this project will improve the operational stability and efficiency of the fuel cell, thereby providing a promising pathway for ammonia fuel cells to replace hydrogen fuel cells. This study will reinforce the development of the future supply of reliable, low cost and clean energy. Read moreRead less
Data-driven modelling of complex reactive flows. Complex reactive flow is dominant in many chemicals, physical and biological processes and should be optimised online for operational efficiency and stability, yet it is hindered by the lack of reliable model techniques. The project tackles this challenge by developing a next-generation data-driven modelling approach via integrating continuum/discrete-scale fluid-particle dynamics with system/control theories, supported by lab/plant experiments. D ....Data-driven modelling of complex reactive flows. Complex reactive flow is dominant in many chemicals, physical and biological processes and should be optimised online for operational efficiency and stability, yet it is hindered by the lack of reliable model techniques. The project tackles this challenge by developing a next-generation data-driven modelling approach via integrating continuum/discrete-scale fluid-particle dynamics with system/control theories, supported by lab/plant experiments. Driven by online data, the generic approach can open up a powerful way to reliably describe the inner state of reactors and online predict operation anomalies. The outcomes can help transform a range of industries to smart manufacturing and design, which is vital to Australia's technological future.Read moreRead less
Hybrid Hydrocarbon-Carbon Fuel Cells for Long-Life Power Generation. This project aims to design an innovative high-energy portable power source based on a hybrid direct hydrocarbon-carbon fuel cell concept, in which the deposited carbon in the anode of a fuel cell during operation with liquid hydrocarbon fuels can be used as a fuel by subsequent operation in the direct carbon fuel cell mode. The key concept in this project is the controlled deposition and utilization of carbon over the anode of ....Hybrid Hydrocarbon-Carbon Fuel Cells for Long-Life Power Generation. This project aims to design an innovative high-energy portable power source based on a hybrid direct hydrocarbon-carbon fuel cell concept, in which the deposited carbon in the anode of a fuel cell during operation with liquid hydrocarbon fuels can be used as a fuel by subsequent operation in the direct carbon fuel cell mode. The key concept in this project is the controlled deposition and utilization of carbon over the anode of the fuel cell by systematic modelling and experimental development. A continuous power output will be realized via an intelligent cycling mode with an intermittent supply of pure liquid hydrocarbon fuels, thereby achieving an extremely high fuel utilization efficiency in a hybrid electrochemical system.Read moreRead less
Targeting Iron Piracy From Host Proteins By Neisseria And Haemophilus Spp. For The Development Of Novel Antimicrobials
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
The bacteria that cause the sexually transmitted infection gonorrhoea and meningococcal disease are a serious health concern. In order to cause disease, these bacteria must obtain the nutrient iron from our bodies. This proposed research will use cutting edge technologies to understand on a molecular level how these bacteria obtain iron during infection. It will then apply this knowledge to develop molecules that prevent these bacteria from obtaining iron, as a means of treating these diseases.