The Effect Of Selected Nutraceuticals On Brain Blood Vessels And Memory.
Funder
National Health and Medical Research Council
Funding Amount
$445,206.00
Summary
The human brain receives 1000L of blood per day, distributed through minute vessels called capillaries. The integrity and function of brain capillaries is compromised with aging and this may contribute to memory disturbances. Our laboratory has identified several naturally occurring compounds that prevent age-associated defects of brain capillaries. The primary aim of this project is to explore if these agents are beneficial for restoring brain capillary function and memory.
Neuroimaging changes underpinning improvements in cognition in the elderly. Natural supplements are often used to improve brain and cognitive function, however, we do not know how these supplements work in the brain. Using novel brain imaging scans, the project will investigate whether 12-month administration of two promising natural supplements improves brain markers of ageing and cognitive decline in an elderly population.
Preclinical Development Of A Therapeutic Anticancer Antibody To C-Met
Funder
National Health and Medical Research Council
Funding Amount
$435,530.00
Summary
Many common cancers cannot be effectively treated. A range of these cancers (e.g. gastric and lung cancer) display the molecule c-Met on their cell surface. c-Met promotes tumour growth; therefore, blocking c-Met is a promising strategy for treating these cancers. However, no antibodies or drugs that target c-Met have been licensed. The therapeutics that are being developed to target c-Met all have considerable limitations. Thus, there is an opportunity to develop a 'best-in-class' therapeutic.
Fundamental research for advanced gasification technologies for low-rank coal and biomass in the carbon-constrained world. This project aims to acquire fundamental knowledge in order to develop advanced gasification technologies with high efficiencies and the capability to couple with carbon storage facilities in the carbon-constrained future. These technologies will contribute to the reduction of Australia's CO2 emissions using its cheap low-rank coal and biomass.
Phase stability of biomass fast pyrolysis bio-oil: behaviour and control. This project aims to carry out a systematic investigation into the phase behaviour and control of biomass fast pyrolysis into bio-oil and its derived fuels. The project addresses the major problem of fuel phase separation during processing and handling that cause significant operational challenges, for example pumping difficulties and line clogging, during storage, transport and applications of these fuels. The outcomes in ....Phase stability of biomass fast pyrolysis bio-oil: behaviour and control. This project aims to carry out a systematic investigation into the phase behaviour and control of biomass fast pyrolysis into bio-oil and its derived fuels. The project addresses the major problem of fuel phase separation during processing and handling that cause significant operational challenges, for example pumping difficulties and line clogging, during storage, transport and applications of these fuels. The outcomes include the discovery of fundamental knowledge on the phase structure, stability and behaviour of the products of biomass fast pyrolysis bio-oil and its derived fuels and the development of essential engineering tools for predicting and controlling phase behaviour and stability of these fuels.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101215
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
A novel pyrolysis process for high-quality bio-oil production from biomass. The project outcome will provide fundamental knowledge essential to the development of a novel pyrolysis process for high-quality bio-oil production with biochar, a value-added by-product. It will largely accelerate the commercialisation of the biomass pyrolysis process to reduce greenhouse gas emissions and fossil fuel use in the energy sector.
Advanced biomass gasification process for distributed power generation with significant negative carbon emission in rural and regional Australia. The outcome of this project is fundamental knowledge essential to the development of advanced biomass gasification processes for distributed power generation with drastic reduction in carbon emissions and the recycling of inorganic nutrients to the land. It will contribute significantly to the future sustainability of rural and regional Australia.
Integrated photo and thermal catalysis for economic carbon dioxide conversion to fuels. The project aims to develop an integrated process for simultaneously photo- and thermal-catalytic conversion of carbon dioxide and water vapour to hydrocarbon fuels and chemicals using solar light and waste heat from flue gas. This project will design and make multi-functional catalysts based on zirconium metal organic frameworks, incorporating quantum dots and metal nanoclusters. This project is expected to ....Integrated photo and thermal catalysis for economic carbon dioxide conversion to fuels. The project aims to develop an integrated process for simultaneously photo- and thermal-catalytic conversion of carbon dioxide and water vapour to hydrocarbon fuels and chemicals using solar light and waste heat from flue gas. This project will design and make multi-functional catalysts based on zirconium metal organic frameworks, incorporating quantum dots and metal nanoclusters. This project is expected to develop an advanced materials system, reduce carbon dioxide and use it to produce fuel, and harness solar energy. The project should advance Australia’s leading role in reducing carbon emission, and producing clean energy and nanotechnology.Read moreRead less
Studying the impact of pulsed magnetic fields on neural tissue. This project will determine the optimal parameters of pulsed magnetic fields for treating the ageing and/or damaged brain. The safety features, low cost and compact size of the medical device being investigated maximise compliance and make it relevant to populations in remote and rural areas.
Oxy-cofiring of bio-slurry and coal for carbon-negative power generation. This project aims to study co-firing characteristics of bio-slurry fuels and coal under oxy-pulverised-fuel (oxy-PF) conditions. Oxy-PF stationary systems can capture the renewable carbon embedded in bio-slurry fuel from biomass pyrolysis for sequestration, leading to carbon-negative power generation. The expected outcomes are critical knowledge and data regarding the underlying thermochemical reactions responsible for the ....Oxy-cofiring of bio-slurry and coal for carbon-negative power generation. This project aims to study co-firing characteristics of bio-slurry fuels and coal under oxy-pulverised-fuel (oxy-PF) conditions. Oxy-PF stationary systems can capture the renewable carbon embedded in bio-slurry fuel from biomass pyrolysis for sequestration, leading to carbon-negative power generation. The expected outcomes are critical knowledge and data regarding the underlying thermochemical reactions responsible for the co-pyrolysis, volatiles/char co-firing and ash formation from bio-slurry/coal co-firing under oxy-PF conditions. This is expected to enhance Australia's competitive advantage in clean power generation through high-impact scientific and technological innovations, and strengthen the related knowledge and skill base in the country.Read moreRead less