Neuroimaging changes underpinning improvements in cognition in the elderly. Natural supplements are often used to improve brain and cognitive function, however, we do not know how these supplements work in the brain. Using novel brain imaging scans, the project will investigate whether 12-month administration of two promising natural supplements improves brain markers of ageing and cognitive decline in an elderly population.
Nanoliposomal delivery of docosahexaenoic acid (DHA) to neuronal cells. Omega-3 fatty acids such as docosahexaenoic acid (DHA) are essential for brain function. They are effective as adjunct treatments for depression, but at high doses. The project will develop nanoliposomes to target delivery of DHA to brain cells. Efficient delivery of DHA to brain cells will increase its effectiveness as a dietary supplement and lessen the burden of disease.
Preclinical Development Of A Therapeutic Anticancer Antibody To C-Met
Funder
National Health and Medical Research Council
Funding Amount
$435,530.00
Summary
Many common cancers cannot be effectively treated. A range of these cancers (e.g. gastric and lung cancer) display the molecule c-Met on their cell surface. c-Met promotes tumour growth; therefore, blocking c-Met is a promising strategy for treating these cancers. However, no antibodies or drugs that target c-Met have been licensed. The therapeutics that are being developed to target c-Met all have considerable limitations. Thus, there is an opportunity to develop a 'best-in-class' therapeutic.
Australian Laureate Fellowships - Grant ID: FL200100049
Funder
Australian Research Council
Funding Amount
$2,906,992.00
Summary
Nanofluidic Membranes for Sustainable Energy Future. This project aims to create a novel class of advanced membranes by making fundamental breakthroughs in nanofluidics, and harnessing this for developing new renewable energy and low-energy separation technologies. This project addresses the key challenges in understanding selective mass transport at the angstrom scale, thereby allowing the development of innovative materials design strategies to realise the ultrafast molecular and ionic permeat ....Nanofluidic Membranes for Sustainable Energy Future. This project aims to create a novel class of advanced membranes by making fundamental breakthroughs in nanofluidics, and harnessing this for developing new renewable energy and low-energy separation technologies. This project addresses the key challenges in understanding selective mass transport at the angstrom scale, thereby allowing the development of innovative materials design strategies to realise the ultrafast molecular and ionic permeation, and the ultrahigh selectivities observed in biological cell membranes. This new cross-disciplinary research will benefit Australia by the development of new materials for accelerating renewable hydrogen and biofuel futures, and enabling sustainable production of energy materials.Read moreRead less
An Integrated Approach For The Efffective Adoptive Immunotherapy Of Cancer
Funder
National Health and Medical Research Council
Funding Amount
$468,119.00
Summary
Killer T lymphocytes can penetrate tumors and their transfer into cancer patients has demonstrated some encouraging results, but this form of immunotherapy remain ineffective in most cancer patients. We propose to improve the tumor trafficking and anti-tumor activities of killer cells by genetically engineering them with proteins that will enable them to recognise and destroy cancer cells. The outcomes of this project will validate this novel approach for treatment of cancer patients.
Utilization Of Gene-engineered T Cells For Enhancing Cancer Immunotherapy
Funder
National Health and Medical Research Council
Funding Amount
$761,656.00
Summary
Killer T lymphocytes can penetrate tumours and their transfer into cancer patients has demonstrated some encouraging results, but this form of therapy and other approaches including vaccination remain ineffective in most cancer patients. In this project, we propose to improve the tumour trafficking and anti-tumour activities of killer cells by genetically engineering them with proteins that will enable them to recognise and destroy cancer cells, whilst minimizing toxicity to normal tissue.
New Strategies For Enhancing Chimeric Antigen Receptor (CAR) T Cell Therapy For Cancer
Funder
National Health and Medical Research Council
Funding Amount
$849,540.00
Summary
The role of the immune system in cancer is now recognised as highly important, highlighted by the success of immunotherapy in patients. Yet many patients fail to respond to this form of treatment due to low frequency of lymphocytes present at the tumor site. A new form of immunotherapy involving transfer of gene-modified lymphocytes is a potential way to overcome this problem. This project will explore new strategies to enhance the utility of this approach against blood and solid cancers.
Making best use of biofuels – understanding the interactions between alcohol and hydrocarbon fuels in engine combustion. Biofuels are increasingly used as blending components for transport fuels. Biofuels possess much different chemical structures from conventional fuels, and can therefore interact with hydrocarbon fuels during engine combustion processes and consequently affect engine efficiency and emissions. This project aims to investigate the chemical interactions between representative com ....Making best use of biofuels – understanding the interactions between alcohol and hydrocarbon fuels in engine combustion. Biofuels are increasingly used as blending components for transport fuels. Biofuels possess much different chemical structures from conventional fuels, and can therefore interact with hydrocarbon fuels during engine combustion processes and consequently affect engine efficiency and emissions. This project aims to investigate the chemical interactions between representative compounds of biofuels (ethanol) and fossil fuels (n-heptane, iso-octane and toluene) during engine autoignition processes. The outcomes will fill a significant gap in our understanding for biofuel combustion chemistry, essential for building predictive combustion models, and will guide the best use of the precious Australian biofuel resources to reduce carbon dioxide emissions. Read moreRead less