Neuroimaging changes underpinning improvements in cognition in the elderly. Natural supplements are often used to improve brain and cognitive function, however, we do not know how these supplements work in the brain. Using novel brain imaging scans, the project will investigate whether 12-month administration of two promising natural supplements improves brain markers of ageing and cognitive decline in an elderly population.
Natural gas direct injection in advanced engines and powertrains. Natural gas direct injection in advanced engines and powertrains. This project aims to quantify and understand how future, advanced passenger vehicles might perform when optimised for the direct injection (DI) of natural gas. Such production vehicles do not exist, largely because production DI systems for natural gas, spark ignition engines are not yet available. This project will examine both advanced conventional and hybrid vehi ....Natural gas direct injection in advanced engines and powertrains. Natural gas direct injection in advanced engines and powertrains. This project aims to quantify and understand how future, advanced passenger vehicles might perform when optimised for the direct injection (DI) of natural gas. Such production vehicles do not exist, largely because production DI systems for natural gas, spark ignition engines are not yet available. This project will examine both advanced conventional and hybrid vehicles using a suite of state-of-the-art experimental and numerical techniques. This project will quantify these vehicles’ environmental, technical and economic performance to determine whether DI natural gas, conventional and hybrid vehicles might reduce substantial greenhouse gas (GHG) emissions whilst avoiding any consumer penalty. This research could contribute to global GHG abatement.Read moreRead less
Examining healthcare professionals' communication across the surgical pathway to improve patient safety. Recent data show breakdowns in communication contributed to 16% of sentinel events in Australia, the majority of which were of a surgical nature. Financial costs associated with adverse events are enormous, estimated at around $A2billion/year. Economic burden is predicted to increase with further complexities surrounding patients' surgical care. This study will result in new knowledge about c ....Examining healthcare professionals' communication across the surgical pathway to improve patient safety. Recent data show breakdowns in communication contributed to 16% of sentinel events in Australia, the majority of which were of a surgical nature. Financial costs associated with adverse events are enormous, estimated at around $A2billion/year. Economic burden is predicted to increase with further complexities surrounding patients' surgical care. This study will result in new knowledge about communication patterns to inform the development of reporting methods and strategies that positively influence the practices of healthcare professionals. Strategies could be extrapolated to the broader healthcare sector, and provide tactical direction aimed at averting clinical errors, preventing patient harm and reducing healthcare costs.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
In-situ catalytic upgrading of bio-oil using scrap tyre char. This project aims to develop advanced, cost-competitive catalysts based on scrap tyre char, an otherwise low-value by-product. These catalysts will be optimised for use in upgrading bio-oil derived from the pyrolysis of woody eucalyptus, an abundant biomass resource across Australia. The project is expected to promote the commercialisation of bio-oil production and enhance the valorisation of scrap tyre char. This is expected to reduc ....In-situ catalytic upgrading of bio-oil using scrap tyre char. This project aims to develop advanced, cost-competitive catalysts based on scrap tyre char, an otherwise low-value by-product. These catalysts will be optimised for use in upgrading bio-oil derived from the pyrolysis of woody eucalyptus, an abundant biomass resource across Australia. The project is expected to promote the commercialisation of bio-oil production and enhance the valorisation of scrap tyre char. This is expected to reduce the carbon footprint from Australian industry, and promote the recycling and reuse of waste scrap tyres.Read moreRead less
Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to ....Biophysical identification of natural human antibody targets. A natural human antibody, PAT-SM6, isolated using technology developed by the partner organisation (Patrys), offers promise as a therapy to reduce mortalities due to cancer, the leading cause of death in Australia. The novelty of the approach pioneered by Patrys is the direct production of human antibodies which avoids undesirable side effects associated with the use of antibodies containing non-human components. This project is to discover the specificity of PAT-SM6 for proteins and protein complexes and how these interactions lead to tumour cell death. This work will enhance the effectiveness of human antibody therapies and help in the development of this fast growing area within the biotechnology industry in Australia.Read moreRead less
Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social dev ....Bilateral Cochlear Implants for Children: Does a Second Implant Improve Language, Psychosocial and Other Outcomes? Severe-profound congenital hearing loss engenders significant costs to society. In 2005, specialised education cost -- on average $25,000 per child, loss of productivity cost -- $6.7 billion, and social security benefits were paid to approximately 129,000 individuals who were unemployed due to hearing loss. If bilateral cochlear implantation results in improved language, social development, and academic outcomes, the community benefits arising will be greatly improved quality of life for these individuals and significant savings to society. In partnership with Cochlear Ltd, this study will provide some of the first data worldwide comparing the effects of an additional implant on language, social and educational outcomes.Read moreRead less
A novel mineral looping tar removal process for biomass gasification. A novel mineral looping tar removal process for biomass gasification. This project aims to develop a simple, robust and cost effective method for removing tar from biomass gasification processes. The solution (Mineral Looping Tar Removal) involves the cyclic carbonation and calcination of a mixture of naturally occurring minerals and/or solid waste to remove tar. This project will bring together energy researchers and renewabl ....A novel mineral looping tar removal process for biomass gasification. A novel mineral looping tar removal process for biomass gasification. This project aims to develop a simple, robust and cost effective method for removing tar from biomass gasification processes. The solution (Mineral Looping Tar Removal) involves the cyclic carbonation and calcination of a mixture of naturally occurring minerals and/or solid waste to remove tar. This project will bring together energy researchers and renewable energy developers to resolve science and engineering issues that underpin the performance degradation of these minerals in large-scale settings. Project outcomes include improved understanding of gas cleaning and a cost effective and environmentally sound technology.Read moreRead less
Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This inform ....Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This information will provide the basis for tailoring treatment to a patients needs. It is anticipated that marketing of the PD GeneChip within Australia and overseas may produce revenue of at least $40 million annually.Read moreRead less
Generating a targeted mutation resource in zebrafish. How do genes function to build organisms and how are they regulated to produce organs and tissues? Using a new technique to target specific genes in the genome of zebrafish, this project will determine how genes control formation of different tissues. The new gene "knockout" technology will fundamentally change our understanding of how genes work during development.