Mechanism of synergy of ingredients in natural products and functional foods. Synergism is the interaction of two substances to produce an effect larger than the sum of the separate effects. This project aims to determine the basic biological mechanisms or molecular targets by which the synergy is occurring and to identify the bioactive compounds involved. Understanding how synergism works should help us to identify other synergistic compounds, allowing optimization of products for better effica ....Mechanism of synergy of ingredients in natural products and functional foods. Synergism is the interaction of two substances to produce an effect larger than the sum of the separate effects. This project aims to determine the basic biological mechanisms or molecular targets by which the synergy is occurring and to identify the bioactive compounds involved. Understanding how synergism works should help us to identify other synergistic compounds, allowing optimization of products for better efficacy and quality, and leading to new products that have a significant market advantage over currently available products. This project will help to develop improved natural products that could push this industry advantage further.Read moreRead less
Development of engine management systems for turbocharged gasoline direct-injection engines with optional natural gas port-injection. This project aims to develop universal and programmable engine management systems for gasoline direct-injection engines with lean-burn technology and optional natural gas port-injection. The new engine management system will enable higher fuel efficiency than its predecessors and the increased use of nationally-produced natural gas. The project aims to overcome th ....Development of engine management systems for turbocharged gasoline direct-injection engines with optional natural gas port-injection. This project aims to develop universal and programmable engine management systems for gasoline direct-injection engines with lean-burn technology and optional natural gas port-injection. The new engine management system will enable higher fuel efficiency than its predecessors and the increased use of nationally-produced natural gas. The project aims to overcome three main problems that limit efficiency improvement of direct-injection engines, namely: misfiring, unstable combustion, and soot emission. How these issues are impacted by additional natural gas port-injection will also be explored. This project aims to accomplish this by combining fundamental in-cylinder optical measurements and detailed modelling.Read moreRead less
Use of Gradipore technology to develop novel methods for the preparation and segregation of mammalian spermatozoa. The purpose of this project is to harness the expertise available within an Australian biotechnology company, Gradipore, to develop novel methods for the preparation of mammalian spermatozoa and the segregation of these cells into X-and Y- bearing populations. This technology will find application in: (1)clinical andrology, where rapid, safe protocols for the preparation and segrega ....Use of Gradipore technology to develop novel methods for the preparation and segregation of mammalian spermatozoa. The purpose of this project is to harness the expertise available within an Australian biotechnology company, Gradipore, to develop novel methods for the preparation of mammalian spermatozoa and the segregation of these cells into X-and Y- bearing populations. This technology will find application in: (1)clinical andrology, where rapid, safe protocols for the preparation and segregation of human spermatozoa are being actively sought in the context of assisted conception and the management of sex-linked genetic diseases and (2) agriculture, particularly the cattle industry, where a capacity to predetermine the sex of the offspring would be extremely valuable.Read moreRead less
Microwave-generated plasma combustion for in-cylinder soot reduction. Microwave-generated plasma combustion for in-cylinder soot reduction. This project aims to develop a microwave-generated plasma combustion system for the in-cylinder formation of hydroxyl radicals, achieving cost-effective reduction of engine-out emissions in diesel engines. This new system should overcome high-load particulate emissions and high-cost fuel injection systems, which limit further improvement of diesel engines. T ....Microwave-generated plasma combustion for in-cylinder soot reduction. Microwave-generated plasma combustion for in-cylinder soot reduction. This project aims to develop a microwave-generated plasma combustion system for the in-cylinder formation of hydroxyl radicals, achieving cost-effective reduction of engine-out emissions in diesel engines. This new system should overcome high-load particulate emissions and high-cost fuel injection systems, which limit further improvement of diesel engines. This project expects to accomplish this by combining laser diagnostics in optical combustion facilities and computational modelling, which should lead to the scientific knowledge accelerating the development cycle of the new system.Read moreRead less
Synthetic natural gas and biochar from biomass for energy services in remote communities and soil carbon sequestration. Resources, industry and rural communities, the backbone of Australian economy, are confronted by unprecedented challenges of carbon pollution reduction, land conservation and eco-sustainability to combat global climate change. This exciting, highly integrated and multidisciplinary project will develop a scientific basis and technological options for the resources industry and r ....Synthetic natural gas and biochar from biomass for energy services in remote communities and soil carbon sequestration. Resources, industry and rural communities, the backbone of Australian economy, are confronted by unprecedented challenges of carbon pollution reduction, land conservation and eco-sustainability to combat global climate change. This exciting, highly integrated and multidisciplinary project will develop a scientific basis and technological options for the resources industry and remote communities to respond to these challenges. The outcomes of this research will enable the deployment of renewable biomass energy technology, bio-char for carbon storage, and affect the restoration of marginal lands and salinity levels in an environmentally and economically sustainable way, thus contributing to the development of an environmentally sustainable Australia.Read moreRead less
Participation following traumatic brain injury in rural, regional and remote areas. The results of this project will lead to improved rehabilitation programs and better outcomes for people with brain injury, especially in regional, rural and remote areas, by targeting the ultimate goal more directly: participation - getting people back into their home, work and community roles. Participation is associated with improved social networks, wellbeing, independence and quality of life, so health care ....Participation following traumatic brain injury in rural, regional and remote areas. The results of this project will lead to improved rehabilitation programs and better outcomes for people with brain injury, especially in regional, rural and remote areas, by targeting the ultimate goal more directly: participation - getting people back into their home, work and community roles. Participation is associated with improved social networks, wellbeing, independence and quality of life, so health care burdens and costs are reduced, and people can lead more productive lives. The project's emphasis on country areas will benefit rural health care, and also help specialist metropolitan brain injury services to understand the specific rehabilitation issues facing people from the bush.Read moreRead less
Gene therapy to enhance auditory prosthesis performance for cochlear implants. The cochlear implant is the most effective neural prosthesis, restoring hearing to the deaf. The research aims to develop a new type of implant compatible with delivery of therapeutic genes to the cells lining the cochlea. Gene therapy DNA constructs will be developed that will enhance neural survival and growth, improving cochlear implant performance. The research will provide advances in understanding how to tran ....Gene therapy to enhance auditory prosthesis performance for cochlear implants. The cochlear implant is the most effective neural prosthesis, restoring hearing to the deaf. The research aims to develop a new type of implant compatible with delivery of therapeutic genes to the cells lining the cochlea. Gene therapy DNA constructs will be developed that will enhance neural survival and growth, improving cochlear implant performance. The research will provide advances in understanding how to transfer genes into cochlear tissue, as well as development of gene cassettes for effective neural repair. The work will advance the field of bionics, an area where Australia is establishing international preeminence.Read moreRead less
Investigation of the coupled dependence of concentrated solar radiation and combustion in a novel solar hybrid technology. The project will develop the models necessary for the optimisation of a novel solar-combustion hybrid technology and a novel heat exchanger component. It will deliver a solar thermal technology that lowers the cost of solar energy with immediate potential in off-grid sites, such as in remote mines, in Australia and throughout the world.
Commercial scale production of biocrude by hydrothermal liquefaction. The project aims to develop new understanding and tools to support commercial-scale production of biocrude from microalgae or biosolids and enable a breakthrough in cost-effective production of sustainable fuels. A novel hydrothermal liquefaction reactor has been developed that has strong potential to overcome the limitations of Muradel's existing demonstration reactor which, while world-leading, is uneconomical at commercial ....Commercial scale production of biocrude by hydrothermal liquefaction. The project aims to develop new understanding and tools to support commercial-scale production of biocrude from microalgae or biosolids and enable a breakthrough in cost-effective production of sustainable fuels. A novel hydrothermal liquefaction reactor has been developed that has strong potential to overcome the limitations of Muradel's existing demonstration reactor which, while world-leading, is uneconomical at commercial scale. The project aims to develop design tools to optimise the new reactor, comprising a chemical model of the complex, multi-component hydrothermal liquefaction reactions, a computational model of the mixing and heat transfer within it and a network model of the energy and exergy flows.Read moreRead less
Development of low emissions compression-ignition engines via ethanol port-injection dual-fuelling. The project aims to develop a more efficient and more cost-effective way of utilising clean-burning ethanol fuel. Port-injection fuelling of ethanol as a separate fuel stream in compression-ignition engines will be studied fundamentally and combined with novel combustion strategies to overcome problems that occur at high ethanol substitution.