Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines. Steroidal saponins are a class of natural products that are common constituents of many herbal medicines and have been associated with many biological activities. Comprehensive studies into their biological activities are hampered by the small quantities available through isolation and the complexity of synthesis. The aim of this project is to identify, isolate and express the biosynthetic genes responsible ....Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines. Steroidal saponins are a class of natural products that are common constituents of many herbal medicines and have been associated with many biological activities. Comprehensive studies into their biological activities are hampered by the small quantities available through isolation and the complexity of synthesis. The aim of this project is to identify, isolate and express the biosynthetic genes responsible for the critical steps in the synthesis of these compounds in the herbs themselves. This will allow for production of steroidal saponins using the isolated enzymes, facilitate biological studies and allow the production of critical standards required by the herbal industry for validation and regulation of herbal extracts.Read moreRead less
Neuroimaging changes underpinning improvements in cognition in the elderly. Natural supplements are often used to improve brain and cognitive function, however, we do not know how these supplements work in the brain. Using novel brain imaging scans, the project will investigate whether 12-month administration of two promising natural supplements improves brain markers of ageing and cognitive decline in an elderly population.
Evaluating viscum album in tumour eradication strategies. Extracts from the plant parasite mistletoe are, internationally, the most widely used complementary cancer treatments. Providing clear evidence-based research, this project will focus on enhancing mistletoe anti-cancer treatment through the development of novel liposome-based tumour therapies.
Pharmacological investigation of medicinal plant products from Kaanju Homelands, Wenlock and Pascoe Rivers, Cape York Peninsula. This research will examine the potential for products to be developed from plants on Kaanju homelands. Kaanju people have an immense ecological knowledge accumulated over generations, about the natural resources in an area recognised as being one of Australia's most biologically diverse. Preservation of this knowledge is critical not only to Kaanju people but to the he ....Pharmacological investigation of medicinal plant products from Kaanju Homelands, Wenlock and Pascoe Rivers, Cape York Peninsula. This research will examine the potential for products to be developed from plants on Kaanju homelands. Kaanju people have an immense ecological knowledge accumulated over generations, about the natural resources in an area recognised as being one of Australia's most biologically diverse. Preservation of this knowledge is critical not only to Kaanju people but to the heritage of the Nation as a whole. The research also addresses the National priority 'Promoting & maintaining good health' through the investigation of novel pharmacological activities in areas of cardiovascular health, diabetes and cancer. The collaborative research partnership will serve as a model to assist other Aboriginal organisations, particularly in rural & remote areas.Read moreRead less
Studying the impact of pulsed magnetic fields on neural tissue. This project will determine the optimal parameters of pulsed magnetic fields for treating the ageing and/or damaged brain. The safety features, low cost and compact size of the medical device being investigated maximise compliance and make it relevant to populations in remote and rural areas.
Mechanism of synergy of ingredients in natural products and functional foods. Synergism is the interaction of two substances to produce an effect larger than the sum of the separate effects. This project aims to determine the basic biological mechanisms or molecular targets by which the synergy is occurring and to identify the bioactive compounds involved. Understanding how synergism works should help us to identify other synergistic compounds, allowing optimization of products for better effica ....Mechanism of synergy of ingredients in natural products and functional foods. Synergism is the interaction of two substances to produce an effect larger than the sum of the separate effects. This project aims to determine the basic biological mechanisms or molecular targets by which the synergy is occurring and to identify the bioactive compounds involved. Understanding how synergism works should help us to identify other synergistic compounds, allowing optimization of products for better efficacy and quality, and leading to new products that have a significant market advantage over currently available products. This project will help to develop improved natural products that could push this industry advantage further.Read moreRead less
Development of engine management systems for turbocharged gasoline direct-injection engines with optional natural gas port-injection. This project aims to develop universal and programmable engine management systems for gasoline direct-injection engines with lean-burn technology and optional natural gas port-injection. The new engine management system will enable higher fuel efficiency than its predecessors and the increased use of nationally-produced natural gas. The project aims to overcome th ....Development of engine management systems for turbocharged gasoline direct-injection engines with optional natural gas port-injection. This project aims to develop universal and programmable engine management systems for gasoline direct-injection engines with lean-burn technology and optional natural gas port-injection. The new engine management system will enable higher fuel efficiency than its predecessors and the increased use of nationally-produced natural gas. The project aims to overcome three main problems that limit efficiency improvement of direct-injection engines, namely: misfiring, unstable combustion, and soot emission. How these issues are impacted by additional natural gas port-injection will also be explored. This project aims to accomplish this by combining fundamental in-cylinder optical measurements and detailed modelling.Read moreRead less
Optimising gaseous and particulate emissions from diesel engines. About $3.7 billion is spent annually in Australia on respiratory diseases. Diesel vehicle emissions of nano- and ultra-fine urban air particulate pollution are a significant factor in this disease. This project will directly addresses this problem by developing a technology to monitor and reduce diesel particulate emissions.
Natural gas direct injection in advanced engines and powertrains. Natural gas direct injection in advanced engines and powertrains. This project aims to quantify and understand how future, advanced passenger vehicles might perform when optimised for the direct injection (DI) of natural gas. Such production vehicles do not exist, largely because production DI systems for natural gas, spark ignition engines are not yet available. This project will examine both advanced conventional and hybrid vehi ....Natural gas direct injection in advanced engines and powertrains. Natural gas direct injection in advanced engines and powertrains. This project aims to quantify and understand how future, advanced passenger vehicles might perform when optimised for the direct injection (DI) of natural gas. Such production vehicles do not exist, largely because production DI systems for natural gas, spark ignition engines are not yet available. This project will examine both advanced conventional and hybrid vehicles using a suite of state-of-the-art experimental and numerical techniques. This project will quantify these vehicles’ environmental, technical and economic performance to determine whether DI natural gas, conventional and hybrid vehicles might reduce substantial greenhouse gas (GHG) emissions whilst avoiding any consumer penalty. This research could contribute to global GHG abatement.Read moreRead less
Examining healthcare professionals' communication across the surgical pathway to improve patient safety. Recent data show breakdowns in communication contributed to 16% of sentinel events in Australia, the majority of which were of a surgical nature. Financial costs associated with adverse events are enormous, estimated at around $A2billion/year. Economic burden is predicted to increase with further complexities surrounding patients' surgical care. This study will result in new knowledge about c ....Examining healthcare professionals' communication across the surgical pathway to improve patient safety. Recent data show breakdowns in communication contributed to 16% of sentinel events in Australia, the majority of which were of a surgical nature. Financial costs associated with adverse events are enormous, estimated at around $A2billion/year. Economic burden is predicted to increase with further complexities surrounding patients' surgical care. This study will result in new knowledge about communication patterns to inform the development of reporting methods and strategies that positively influence the practices of healthcare professionals. Strategies could be extrapolated to the broader healthcare sector, and provide tactical direction aimed at averting clinical errors, preventing patient harm and reducing healthcare costs.Read moreRead less