Mechanisms Of Nanoparticle-mediated Inhibition Of Asthma
Funder
National Health and Medical Research Council
Funding Amount
$637,921.00
Summary
Ultrafine pollution particles may promote asthma, and there is concern that man-made 'nanoparticles' have a similar effect. Surprisingly, we found that inert toxin-free nanoparticles inhibit asthma. We propose nanoparticles do this by leaving a unique �imprint� in the lung. We will explore how this imprint modifies lung inflammatory and immune regulatory cell function, and investigate particles made from advanced biodegradable polymers as potential therapeutics for inflammatory lung diseases suc ....Ultrafine pollution particles may promote asthma, and there is concern that man-made 'nanoparticles' have a similar effect. Surprisingly, we found that inert toxin-free nanoparticles inhibit asthma. We propose nanoparticles do this by leaving a unique �imprint� in the lung. We will explore how this imprint modifies lung inflammatory and immune regulatory cell function, and investigate particles made from advanced biodegradable polymers as potential therapeutics for inflammatory lung diseases such as asthma.Read moreRead less