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Research Topic : AIDS-associated mycobacterial infections
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  • Funded Activity

    Monogamy As An HIV And STI Prevention Strategy For Gay Men

    Funder
    National Health and Medical Research Council
    Funding Amount
    $407,506.00
    Summary
    Monogamy is relatively common among Australian gay men and yet relatively under researched or explored. At present we know little about the motivations of Australian gay men to enter and maintain monogamous relationships. This study will bring into clear view a phenomenon, and social and intimate practice, that has been almost entirely overlooked and will significantly advance our understanding of the dynamics of gay men's sexual behaviour and sexual cultures.
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    Funded Activity

    A Unique Network Of Phagocytic Cells At The Interface Between The Liver And Peritoneal Cavity

    Funder
    National Health and Medical Research Council
    Funding Amount
    $787,521.00
    Summary
    This project aims to characterise the nature and ontogeny of a novel population of cells with phagocytic capacity that forms a network underlying the capsule of mouse and human liver reminiscent of that formed by Langherans cells in the epidermis of the skin. In this project we will characterise this newly described liver capsular macrophage subset, define their ontogeny and assess their specific functions.
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    Funded Activity

    Discovery Of New Tuberculosis Drug Leads Targeting Cell Wall Biosynthesis

    Funder
    National Health and Medical Research Council
    Funding Amount
    $714,816.00
    Summary
    There is a desperate need for the development of new therapies for the treatment of TB due to widespread resistance of Mycobacterium tuberculosis, the causative agent of TB, to current therapies. The overall goal of this research project is to identify new TB drug leads through the development of structural analogues of bacterially-derived natural products called the sansanmycins that inhibit cell wall synthesis in Mycobacterium tuberculosis.
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    Funded Activity

    The Emerging Problem Of Non-tuberculous Mycobacteria Infection: Understanding Aetiology, Geospatial Epidemiology And Developing Interventions

    Funder
    National Health and Medical Research Council
    Funding Amount
    $988,791.00
    Summary
    This project will be largest study of non-tuberculous mycobacterial (NTM) infection in cystic fibrosis. By combining growing the bacteria with detailed information from the CF patient data registry, geographical location and environmental conditions, this study will provide novel insights into factors associated with NTM. Gene sequencing and airway infection profiling will extend understanding and has the potential to identify novel risk factors and biomarkers for NTM-related airways disease.
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    Funded Activity

    A New Class Of Inhibitors For The Treatment Of Tuberculosis

    Funder
    National Health and Medical Research Council
    Funding Amount
    $720,691.00
    Summary
    Tuberculosis (TB) remains a major cause of mortality and morbidity worldwide, with 1.3 million deaths annually. Some strains of the TB bacterium are resistant to all available drugs. We have identified novel chemical structures that display potent and specific activity against pathogenic mycobacteria. In this proposal we will develop optimised derivatives with more potent activity against mycobacteria, assess their stability and toxicity and determine their mode of action.
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    Funded Activity

    Lactic Acid As A Natural Microbicide For HIV

    Funder
    National Health and Medical Research Council
    Funding Amount
    $597,598.00
    Summary
    Topical microbicides are urgently required to protect women from the sexual transmission of HIV. Lactic acid is produced by bacteria that are normally present in the healthy female vaginal tract and is more potent in the inactivation of HIV compared to low pH alone. This study seeks to determine how lactic acid inactivates HIV and to undertake laboratory studies to determine its suitability for development as a topical microbicide to prevent HIV transmission.
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    Funded Activity

    Finding The Missing Katanin Required For Male Fertility

    Funder
    National Health and Medical Research Council
    Funding Amount
    $417,214.00
    Summary
    Microtubules are a key element of all cells, including in the male germ line. In this project we will define the function of the microtubule severing protein KATNA1 in male fertility. This will be achieved using a unique model and state-of-the-art technologies. This project will have immediate relevance to the 1 in 20 Australian men who suffer from infertility but will also inform KATNA1 function in the many other tissues where KATNA1 is produced.
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    Funded Activity

    Dissecting The Central Organisation Of Cough Neural Networks

    Funder
    National Health and Medical Research Council
    Funding Amount
    $880,928.00
    Summary
    Cough is the most prevalent symptom of lung disease and the most common reason for people to seek medical advice. However, cough neural processes are poorly defined and as a result current cough therapies are largely ineffective making cough a significant unmet clinical problem. This project will novel viral strategies to dissect and manipulate cough neural pathways in the brain, providing insights into the neural processing of airway sensations and coughing.
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    Funded Activity

    Low Dose Aspirin And Age-related Macular Degeneration: Randomised Controlled Trial

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,043,189.00
    Summary
    Age-related macular degeneration (AMD) is a major cause of visual impairment in advanced countries, responsible for nearly half of all legal blindness in Australia. Due to increased life expectancy, the number of people with this progressive late onset disease will double by 2025. Aspirin could prevent or delay the onset of AMD in older persons but its bleeding risk also needs to be considered. This project will determine whether treatment with low dose aspirin reduces incidence or progression o .... Age-related macular degeneration (AMD) is a major cause of visual impairment in advanced countries, responsible for nearly half of all legal blindness in Australia. Due to increased life expectancy, the number of people with this progressive late onset disease will double by 2025. Aspirin could prevent or delay the onset of AMD in older persons but its bleeding risk also needs to be considered. This project will determine whether treatment with low dose aspirin reduces incidence or progression of AMD.
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    Funded Activity

    Antibiotic Treatment Of Male Partners To Reduce Recurrence Of Bacterial Vaginosis In Women: A Randomised Double-blind Controlled Trial

    Funder
    National Health and Medical Research Council
    Funding Amount
    $636,674.00
    Summary
    Bacterial vaginosis (BV) is the most common vaginal infection in women. Healthy bacteria are lost and replaced by bacteria that cause unpleasant discharge and odour. BV puts women at increased risk of sexually transmitted infections, HIV, miscarriage and preterm delivery. Over 50% of women given antibiotics get BV back again. Studies suggest these bacteria are being sexually transmitted. We are conducting a trial of antibiotic treatment of women and their male partners to improve BV cure.
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    Showing 1-10 of 100 Funded Activites

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